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Items: 1 to 20 of 108

1.

CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer.

Johnson SF, Cruz C, Greifenberg AK, Dust S, Stover DG, Chi D, Primack B, Cao S, Bernhardy AJ, Coulson R, Lazaro JB, Kochupurakkal B, Sun H, Unitt C, Moreau LA, Sarosiek KA, Scaltriti M, Juric D, Baselga J, Richardson AL, Rodig SJ, D'Andrea AD, Balmaña J, Johnson N, Geyer M, Serra V, Lim E, Shapiro GI.

Cell Rep. 2016 Nov 22;17(9):2367-2381. doi: 10.1016/j.celrep.2016.10.077.

2.

Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors.

Zhang T, Kwiatkowski N, Olson CM, Dixon-Clarke SE, Abraham BJ, Greifenberg AK, Ficarro SB, Elkins JM, Liang Y, Hannett NM, Manz T, Hao M, Bartkowiak B, Greenleaf AL, Marto JA, Geyer M, Bullock AN, Young RA, Gray NS.

Nat Chem Biol. 2016 Oct;12(10):876-84. doi: 10.1038/nchembio.2166.

3.
4.

Cdk12 Is A Gene-Selective RNA Polymerase II Kinase That Regulates a Subset of the Transcriptome, Including Nrf2 Target Genes.

Li X, Chatterjee N, Spirohn K, Boutros M, Bohmann D.

Sci Rep. 2016 Feb 25;6:21455. doi: 10.1038/srep21455.

5.

CDK13, a Kinase Involved in Pre-mRNA Splicing, Is a Component of the Perinucleolar Compartment.

Even Y, Escande ML, Fayet C, Genevière AM.

PLoS One. 2016 Feb 17;11(2):e0149184. doi: 10.1371/journal.pone.0149184.

6.

7SK-BAF axis controls pervasive transcription at enhancers.

Flynn RA, Do BT, Rubin AJ, Calo E, Lee B, Kuchelmeister H, Rale M, Chu C, Kool ET, Wysocka J, Khavari PA, Chang HY.

Nat Struct Mol Biol. 2016 Mar;23(3):231-8. doi: 10.1038/nsmb.3176.

7.

Direct Analysis of Phosphorylation Sites on the Rpb1 C-Terminal Domain of RNA Polymerase II.

Suh H, Ficarro SB, Kang UB, Chun Y, Marto JA, Buratowski S.

Mol Cell. 2016 Jan 21;61(2):297-304. doi: 10.1016/j.molcel.2015.12.021.

8.

Dephosphorylating eukaryotic RNA polymerase II.

Mayfield JE, Burkholder NT, Zhang YJ.

Biochim Biophys Acta. 2016 Apr;1864(4):372-87. doi: 10.1016/j.bbapap.2016.01.007. Review.

PMID:
26779935
9.

The Establishment of a Hyperactive Structure Allows the Tumour Suppressor Protein p53 to Function through P-TEFb during Limited CDK9 Kinase Inhibition.

Albert TK, Antrecht C, Kremmer E, Meisterernst M.

PLoS One. 2016 Jan 8;11(1):e0146648. doi: 10.1371/journal.pone.0146648.

10.

P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates.

Sansó M, Levin RS, Lipp JJ, Wang VY, Greifenberg AK, Quezada EM, Ali A, Ghosh A, Larochelle S, Rana TM, Geyer M, Tong L, Shokat KM, Fisher RP.

Genes Dev. 2016 Jan 1;30(1):117-31. doi: 10.1101/gad.269589.115.

11.

Structures of the CDK12/CycK complex with AMP-PNP reveal a flexible C-terminal kinase extension important for ATP binding.

Dixon-Clarke SE, Elkins JM, Cheng SW, Morin GB, Bullock AN.

Sci Rep. 2015 Nov 24;5:17122. doi: 10.1038/srep17122.

12.

RNA polymerase II pausing as a context-dependent reader of the genome.

Scheidegger A, Nechaev S.

Biochem Cell Biol. 2016 Feb;94(1):82-92. doi: 10.1139/bcb-2015-0045. Review.

13.

Heterochromatin remodeling by CDK12 contributes to learning in Drosophila.

Pan L, Xie W, Li KL, Yang Z, Xu J, Zhang W, Liu LP, Ren X, He Z, Wu J, Sun J, Wei HM, Wang D, Xie W, Li W, Ni JQ, Sun FL.

Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13988-93. doi: 10.1073/pnas.1502943112.

14.

The Central Region of the Drosophila Co-repressor Groucho as a Regulatory Hub.

Kwong PN, Chambers M, Vashisht AA, Turki-Judeh W, Yau TY, Wohlschlegel JA, Courey AJ.

J Biol Chem. 2015 Dec 11;290(50):30119-30. doi: 10.1074/jbc.M115.681171. Erratum in: J Biol Chem. 2016 Mar 25;291(13):6784.

15.

CDK7-dependent transcriptional addiction in triple-negative breast cancer.

Wang Y, Zhang T, Kwiatkowski N, Abraham BJ, Lee TI, Xie S, Yuzugullu H, Von T, Li H, Lin Z, Stover DG, Lim E, Wang ZC, Iglehart JD, Young RA, Gray NS, Zhao JJ.

Cell. 2015 Sep 24;163(1):174-86. doi: 10.1016/j.cell.2015.08.063.

16.

THZ1 Reveals Roles for Cdk7 in Co-transcriptional Capping and Pausing.

Nilson KA, Guo J, Turek ME, Brogie JE, Delaney E, Luse DS, Price DH.

Mol Cell. 2015 Aug 20;59(4):576-87. doi: 10.1016/j.molcel.2015.06.032.

17.

Splicing inhibition decreases phosphorylation level of Ser2 in Pol II CTD.

Koga M, Hayashi M, Kaida D.

Nucleic Acids Res. 2015 Sep 30;43(17):8258-67. doi: 10.1093/nar/gkv740.

18.

Engineering an analog-sensitive CDK12 cell line using CRISPR/Cas.

Bartkowiak B, Yan C, Greenleaf AL.

Biochim Biophys Acta. 2015 Sep;1849(9):1179-87. doi: 10.1016/j.bbagrm.2015.07.010.

19.

Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism.

Lu H, Xue Y, Yu GK, Arias C, Lin J, Fong S, Faure M, Weisburd B, Ji X, Mercier A, Sutton J, Luo K, Gao Z, Zhou Q.

Elife. 2015 Jun 17;4:e06535. doi: 10.7554/eLife.06535. Erratum in: Elife. 2015;4:e09993. Xue, Yuahua [corrected to Xue, Yuhua].

20.

Roles of Prolyl Isomerases in RNA-Mediated Gene Expression.

Thapar R.

Biomolecules. 2015 May 18;5(2):974-99. doi: 10.3390/biom5020974. Review.

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