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Adducin family proteins possess different nuclear export potentials.

Liu CM, Hsu WH, Lin WY, Chen HC.

J Biomed Sci. 2017 May 10;24(1):30. doi: 10.1186/s12929-017-0333-0.


Distinctive Nuclear Localization Signals in the Oomycete Phytophthora sojae.

Fang Y, Jang HS, Watson GW, Wellappili DP, Tyler BM.

Front Microbiol. 2017 Feb 2;8:10. doi: 10.3389/fmicb.2017.00010. eCollection 2017.


Autographa californica Multiple Nucleopolyhedrovirus Ac34 Protein Retains Cellular Actin-Related Protein 2/3 Complex in the Nucleus by Subversion of CRM1-Dependent Nuclear Export.

Mu J, Zhang Y, Hu Y, Hu X, Zhou Y, Zhao H, Pei R, Wu C, Chen J, Zhao H, Yang K, Oers MM, Chen X, Wang Y.

PLoS Pathog. 2016 Nov 1;12(11):e1005994. doi: 10.1371/journal.ppat.1005994. eCollection 2016 Nov.


Heterozygous mutation of cysteine528 in XPO1 is sufficient for resistance to selective inhibitors of nuclear export.

Neggers JE, Vanstreels E, Baloglu E, Shacham S, Landesman Y, Daelemans D.

Oncotarget. 2016 Oct 18;7(42):68842-68850. doi: 10.18632/oncotarget.11995.


Karyopherin-β2 Recognition of a PY-NLS Variant that Lacks the Proline-Tyrosine Motif.

Soniat M, Chook YM.

Structure. 2016 Oct 4;24(10):1802-1809. doi: 10.1016/j.str.2016.07.018. Epub 2016 Sep 8.


Exportin-5 Functions as an Oncogene and a Potential Therapeutic Target in Colorectal Cancer.

Shigeyasu K, Okugawa Y, Toden S, Boland CR, Goel A.

Clin Cancer Res. 2017 Mar 1;23(5):1312-1322. doi: 10.1158/1078-0432.CCR-16-1023. Epub 2016 Aug 23.


Recognition Elements in the Histone H3 and H4 Tails for Seven Different Importins.

Soniat M, Cağatay T, Chook YM.

J Biol Chem. 2016 Sep 30;291(40):21171-21183. Epub 2016 Aug 15.


Mechanistic insights from the recent structures of the CRM1 nuclear export complex and its disassembly intermediate.

Koyama M, Matsuura Y.

Biophysics (Nagoya-shi). 2012 Nov 30;8:145-50. doi: 10.2142/biophysics.8.145. eCollection 2012. Review.


CRM1 inhibitor S109 suppresses cell proliferation and induces cell cycle arrest in renal cancer cells.

Liu X, Chong Y, Liu H, Han Y, Niu M.

Korean J Physiol Pharmacol. 2016 Mar;20(2):161-8. doi: 10.4196/kjpp.2016.20.2.161. Epub 2016 Feb 23.


A Nuclear Attack on Traumatic Brain Injury: Sequestration of Cell Death in the Nucleus.

Tajiri N, De La Peña I, Acosta SA, Kaneko Y, Tamir S, Landesman Y, Carlson R, Shacham S, Borlongan CV.

CNS Neurosci Ther. 2016 Apr;22(4):306-15. doi: 10.1111/cns.12501. Epub 2016 Feb 4.


Nuclear import of the thyroid hormone receptor α1 is mediated by importin 7, importin β1, and adaptor importin α1.

Roggero VR, Zhang J, Parente LE, Doshi Y, Dziedzic RC, McGregor EL, Varjabedian AD, Schad SE, Bondzi C, Allison LA.

Mol Cell Endocrinol. 2016 Jan 5;419:185-97. doi: 10.1016/j.mce.2015.10.016. Epub 2015 Oct 23.


Structural determinants of nuclear export signal orientation in binding to exportin CRM1.

Fung HY, Fu SC, Brautigam CA, Chook YM.

Elife. 2015 Sep 8;4. doi: 10.7554/eLife.10034.


Ribosomal Biogenesis and Translational Flux Inhibition by the Selective Inhibitor of Nuclear Export (SINE) XPO1 Antagonist KPT-185.

Tabe Y, Kojima K, Yamamoto S, Sekihara K, Matsushita H, Davis RE, Wang Z, Ma W, Ishizawa J, Kazuno S, Kauffman M, Shacham S, Fujimura T, Ueno T, Miida T, Andreeff M.

PLoS One. 2015 Sep 4;10(9):e0137210. doi: 10.1371/journal.pone.0137210. eCollection 2015.


An Importin Code in neuronal transport from synapse-to-nucleus?

Lever MB, Karpova A, Kreutz MR.

Front Mol Neurosci. 2015 Jul 21;8:33. doi: 10.3389/fnmol.2015.00033. eCollection 2015. No abstract available.


Activity of a selective inhibitor of nuclear export, selinexor (KPT-330), against AML-initiating cells engrafted into immunosuppressed NSG mice.

Etchin J, Montero J, Berezovskaya A, Le BT, Kentsis A, Christie AL, Conway AS, Chen WC, Reed C, Mansour MR, Ng CE, Adamia S, Rodig SJ, Galinsky IA, Stone RM, Klebanov B, Landesman Y, Kauffman M, Shacham S, Kung AL, Wang JC, Letai A, Look AT.

Leukemia. 2016 Jan;30(1):190-9. doi: 10.1038/leu.2015.194. Epub 2015 Jul 23.


MD simulations and FRET reveal an environment-sensitive conformational plasticity of importin-β.

Halder K, Dölker N, Van Q, Gregor I, Dickmanns A, Baade I, Kehlenbach RH, Ficner R, Enderlein J, Grubmüller H, Neumann H.

Biophys J. 2015 Jul 21;109(2):277-86. doi: 10.1016/j.bpj.2015.06.014.


Intracellular Protein Shuttling: A Mechanism Relevant for Myelin Repair in Multiple Sclerosis?

Göttle P, Küry P.

Int J Mol Sci. 2015 Jul 3;16(7):15057-85. doi: 10.3390/ijms160715057. Review.


Nuclear translocation of fibroblast growth factor-2 (FGF2) is regulated by Karyopherin-β2 and Ran GTPase in human glioblastoma cells.

Wang F, Yang L, Shi L, Li Q, Zhang G, Wu J, Zheng J, Jiao B.

Oncotarget. 2015 Aug 28;6(25):21468-78.


ULK2 Ser 1027 Phosphorylation by PKA Regulates Its Nuclear Localization Occurring through Karyopherin Beta 2 Recognition of a PY-NLS Motif.

Shin SH, Lee EJ, Chun J, Hyun S, Kang SS.

PLoS One. 2015 Jun 8;10(6):e0127784. doi: 10.1371/journal.pone.0127784. eCollection 2015.


Broad targeting of resistance to apoptosis in cancer.

Mohammad RM, Muqbil I, Lowe L, Yedjou C, Hsu HY, Lin LT, Siegelin MD, Fimognari C, Kumar NB, Dou QP, Yang H, Samadi AK, Russo GL, Spagnuolo C, Ray SK, Chakrabarti M, Morre JD, Coley HM, Honoki K, Fujii H, Georgakilas AG, Amedei A, Niccolai E, Amin A, Ashraf SS, Helferich WG, Yang X, Boosani CS, Guha G, Bhakta D, Ciriolo MR, Aquilano K, Chen S, Mohammed SI, Keith WN, Bilsland A, Halicka D, Nowsheen S, Azmi AS.

Semin Cancer Biol. 2015 Dec;35 Suppl:S78-103. doi: 10.1016/j.semcancer.2015.03.001. Epub 2015 Apr 28. Review.

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