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Items: 1 to 20 of 48


Disruptions in asymmetric centrosome inheritance and WDR62-Aurora kinase B interactions in primary microcephaly.

Sgourdou P, Mishra-Gorur K, Saotome I, Henagariu O, Tuysuz B, Campos C, Ishigame K, Giannikou K, Quon JL, Sestan N, Caglayan AO, Gunel M, Louvi A.

Sci Rep. 2017 Mar 8;7:43708. doi: 10.1038/srep43708.


Large-Scale Analysis of CRISPR/Cas9 Cell-Cycle Knockouts Reveals the Diversity of p53-Dependent Responses to Cell-Cycle Defects.

McKinley KL, Cheeseman IM.

Dev Cell. 2017 Feb 27;40(4):405-420.e2. doi: 10.1016/j.devcel.2017.01.012. Epub 2017 Feb 16.


The Consequences of Chromosome Segregation Errors in Mitosis and Meiosis.

Potapova T, Gorbsky GJ.

Biology (Basel). 2017 Feb 8;6(1). pii: E12. doi: 10.3390/biology6010012. Review.


A New Mode of Mitotic Surveillance.

Lambrus BG, Holland AJ.

Trends Cell Biol. 2017 May;27(5):314-321. doi: 10.1016/j.tcb.2017.01.004. Epub 2017 Feb 7. Review.


The PIDDosome activates p53 in response to supernumerary centrosomes.

Fava LL, Schuler F, Sladky V, Haschka MD, Soratroi C, Eiterer L, Demetz E, Weiss G, Geley S, Nigg EA, Villunger A.

Genes Dev. 2017 Jan 1;31(1):34-45. doi: 10.1101/gad.289728.116.


Phosphorylation of XIAP by CDK1-cyclin-B1 controls mitotic cell death.

Hou Y, Allan LA, Clarke PR.

J Cell Sci. 2017 Jan 15;130(2):502-511. doi: 10.1242/jcs.192310. Epub 2016 Dec 7.


Paclitaxel-induced aberrant mitosis and mitotic slippage efficiently lead to proliferative death irrespective of canonical apoptosis and p53.

Yasuhira S, Shibazaki M, Nishiya M, Maesawa C.

Cell Cycle. 2016 Dec;15(23):3268-3277. Epub 2016 Oct 20.


Transcriptome analysis of tetraploid cells identifies cyclin D2 as a facilitator of adaptation to genome doubling in the presence of p53.

Potapova TA, Seidel CW, Box AC, Rancati G, Li R.

Mol Biol Cell. 2016 Oct 15;27(20):3065-3084. Epub 2016 Aug 24.


53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration.

Meitinger F, Anzola JV, Kaulich M, Richardson A, Stender JD, Benner C, Glass CK, Dowdy SF, Desai A, Shiau AK, Oegema K.

J Cell Biol. 2016 Jul 18;214(2):155-66. doi: 10.1083/jcb.201604081.


A USP28-53BP1-p53-p21 signaling axis arrests growth after centrosome loss or prolonged mitosis.

Lambrus BG, Daggubati V, Uetake Y, Scott PM, Clutario KM, Sluder G, Holland AJ.

J Cell Biol. 2016 Jul 18;214(2):143-53. doi: 10.1083/jcb.201604054.


53BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged mitosis.

Fong CS, Mazo G, Das T, Goodman J, Kim M, O'Rourke BP, Izquierdo D, Tsou MF.

Elife. 2016 Jul 2;5. pii: e16270. doi: 10.7554/eLife.16270.


CDK-1 Inhibition in G2 Stabilizes Kinetochore-Microtubules in the following Mitosis.

Gayek AS, Ohi R.

PLoS One. 2016 Jun 9;11(6):e0157491. doi: 10.1371/journal.pone.0157491. eCollection 2016.


Prolonged mitotic arrest induces a caspase-dependent DNA damage response at telomeres that determines cell survival.

Hain KO, Colin DJ, Rastogi S, Allan LA, Clarke PR.

Sci Rep. 2016 May 27;6:26766. doi: 10.1038/srep26766.


Prolonged Mitosis of Neural Progenitors Alters Cell Fate in the Developing Brain.

Pilaz LJ, McMahon JJ, Miller EE, Lennox AL, Suzuki A, Salmon E, Silver DL.

Neuron. 2016 Jan 6;89(1):83-99. doi: 10.1016/j.neuron.2015.12.007.


Tetraploid cells produced by absence of substrate adhesion during cytokinesis are limited in their proliferation and enter senescence after DNA replication.

De Santis Puzzonia M, Gonzalez L, Ascenzi S, Cundari E, Degrassi F.

Cell Cycle. 2016;15(2):274-82. doi: 10.1080/15384101.2015.1127469.


Thirty years of search and capture: The complex simplicity of mitotic spindle assembly.

Heald R, Khodjakov A.

J Cell Biol. 2015 Dec 21;211(6):1103-11. doi: 10.1083/jcb.201510015. Epub 2015 Dec 14. Review.


Aneuploidy causes premature differentiation of neural and intestinal stem cells.

Gogendeau D, Siudeja K, Gambarotto D, Pennetier C, Bardin AJ, Basto R.

Nat Commun. 2015 Nov 17;6:8894. doi: 10.1038/ncomms9894.


Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint.

Bailey ML, Singh T, Mero P, Moffat J, Hieter P.

Genetics. 2015 Nov;201(3):885-95. doi: 10.1534/genetics.115.180653. Epub 2015 Sep 8.


Cenp-E inhibitor GSK923295: Novel synthetic route and use as a tool to generate aneuploidy.

Bennett A, Bechi B, Tighe A, Thompson S, Procter DJ, Taylor SS.

Oncotarget. 2015 Aug 28;6(25):20921-32.


p53 protects against genome instability following centriole duplication failure.

Lambrus BG, Uetake Y, Clutario KM, Daggubati V, Snyder M, Sluder G, Holland AJ.

J Cell Biol. 2015 Jul 6;210(1):63-77. doi: 10.1083/jcb.201502089.

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