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Ubiquitin C-terminal hydrolase37 regulates Tcf7 DNA binding for the activation of Wnt signalling.

Han W, Lee H, Han JK.

Sci Rep. 2017 Feb 15;7:42590. doi: 10.1038/srep42590.


The Proline/Arginine Dipeptide from Hexanucleotide Repeat Expanded C9ORF72 Inhibits the Proteasome.

Gupta R, Lan M, Mojsilovic-Petrovic J, Choi WH, Safren N, Barmada S, Lee MJ, Kalb R.

eNeuro. 2017 Jan 31;4(1). pii: ENEURO.0249-16.2017. doi: 10.1523/ENEURO.0249-16.2017.


Docosahexaenoic acid-mediated protein aggregates may reduce proteasome activity and delay myotube degradation during muscle atrophy in vitro.

Shin SK, Kim JH, Lee JH, Son YH, Lee MW, Kim HJ, Noh SA, Kim KP, Kim IG, Lee MJ.

Exp Mol Med. 2017 Jan 20;49(1):e287. doi: 10.1038/emm.2016.133.


Proteostasis and Diseases of the Motor Unit.

Rinaldi C, Mäger I, Wood MJ.

Front Mol Neurosci. 2016 Dec 27;9:164. doi: 10.3389/fnmol.2016.00164.


The emerging role of deubiquitinating enzymes in genomic integrity, diseases, and therapeutics.

He M, Zhou Z, Shah AA, Zou H, Tao J, Chen Q, Wan Y.

Cell Biosci. 2016 Dec 20;6:62. doi: 10.1186/s13578-016-0127-1. Review.


Dysregulation of Ubiquitin-Proteasome System in Neurodegenerative Diseases.

Zheng Q, Huang T, Zhang L, Zhou Y, Luo H, Xu H, Wang X.

Front Aging Neurosci. 2016 Dec 15;8:303. doi: 10.3389/fnagi.2016.00303. Review.


Cardiac proteasome functional insufficiency plays a pathogenic role in diabetic cardiomyopathy.

Li J, Ma W, Yue G, Tang Y, Kim IM, Weintraub NL, Wang X, Su H.

J Mol Cell Cardiol. 2017 Jan;102:53-60. doi: 10.1016/j.yjmcc.2016.11.013.


Sphingosine 1-phosphate lyase ablation disrupts presynaptic architecture and function via an ubiquitin- proteasome mediated mechanism.

Mitroi DN, Deutschmann AU, Raucamp M, Karunakaran I, Glebov K, Hans M, Walter J, Saba J, Gräler M, Ehninger D, Sopova E, Shupliakov O, Swandulla D, van Echten-Deckert G.

Sci Rep. 2016 Nov 24;6:37064. doi: 10.1038/srep37064.


The role of deubiquitinases in breast cancer.

Xiao Z, Zhang P, Ma L.

Cancer Metastasis Rev. 2016 Dec;35(4):589-600. doi: 10.1007/s10555-016-9640-2.


Deubiquitinase activity is required for the proteasomal degradation of misfolded cytosolic proteins upon heat-stress.

Fang NN, Zhu M, Rose A, Wu KP, Mayor T.

Nat Commun. 2016 Oct 4;7:12907. doi: 10.1038/ncomms12907.


Tuning the proteasome to brighten the end of the journey.

Mayor T, Sharon M, Glickman MH.

Am J Physiol Cell Physiol. 2016 Nov 1;311(5):C793-C804. doi: 10.1152/ajpcell.00198.2016.


Ubiquitin carboxyl-terminal hydrolase-L5 promotes TGFβ-1 signaling by de-ubiquitinating and stabilizing Smad2/Smad3 in pulmonary fibrosis.

Nan L, Jacko AM, Tan J, Wang D, Zhao J, Kass DJ, Ma H, Zhao Y.

Sci Rep. 2016 Sep 8;6:33116. doi: 10.1038/srep33116.


USP14 regulates autophagy by suppressing K63 ubiquitination of Beclin 1.

Xu D, Shan B, Sun H, Xiao J, Zhu K, Xie X, Li X, Liang W, Lu X, Qian L, Yuan J.

Genes Dev. 2016 Aug 1;30(15):1718-30. doi: 10.1101/gad.285122.116.


DUBbing Cancer: Deubiquitylating Enzymes Involved in Epigenetics, DNA Damage and the Cell Cycle As Therapeutic Targets.

Pinto-Fernandez A, Kessler BM.

Front Genet. 2016 Jul 28;7:133. doi: 10.3389/fgene.2016.00133. eCollection 2016 Jul 28. Review.


Substrate Ubiquitination Controls the Unfolding Ability of the Proteasome.

Reichard EL, Chirico GG, Dewey WJ, Nassif ND, Bard KE, Millas NE, Kraut DA.

J Biol Chem. 2016 Aug 26;291(35):18547-61. doi: 10.1074/jbc.M116.720151.


Structures of Rpn1 T1:Rad23 and hRpn13:hPLIC2 Reveal Distinct Binding Mechanisms between Substrate Receptors and Shuttle Factors of the Proteasome.

Chen X, Randles L, Shi K, Tarasov SG, Aihara H, Walters KJ.

Structure. 2016 Aug 2;24(8):1257-70. doi: 10.1016/j.str.2016.05.018.


Platinum-containing compound platinum pyrithione is stronger and safer than cisplatin in cancer therapy.

Zhao C, Chen X, Zang D, Lan X, Liao S, Yang C, Zhang P, Wu J, Li X, Liu N, Liao Y, Huang H, Shi X, Jiang L, Liu X, He Z, Wang X, Liu J.

Biochem Pharmacol. 2016 Sep 15;116:22-38. doi: 10.1016/j.bcp.2016.06.019.


Visualizing K48 Ubiquitination during Presynaptic Formation By Ubiquitination-Induced Fluorescence Complementation (UiFC).

Pinto MJ, Pedro JR, Costa RO, Almeida RD.

Front Mol Neurosci. 2016 Jun 10;9:43. doi: 10.3389/fnmol.2016.00043.


Allosteric Activation of Ubiquitin-Specific Proteases by β-Propeller Proteins UAF1 and WDR20.

Li H, Lim KS, Kim H, Hinds TR, Jo U, Mao H, Weller CE, Sun J, Chatterjee C, D'Andrea AD, Zheng N.

Mol Cell. 2016 Jul 21;63(2):249-60. doi: 10.1016/j.molcel.2016.05.031.


An assay for 26S proteasome activity based on fluorescence anisotropy measurements of dye-labeled protein substrates.

Bhattacharyya S, Renn JP, Yu H, Marko JF, Matouschek A.

Anal Biochem. 2016 Sep 15;509:50-9. doi: 10.1016/j.ab.2016.05.026.


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