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Items: 18


Clinical concentrations of chemically diverse general anesthetics minimally affect lipid bilayer properties.

Herold KF, Sanford RL, Lee W, Andersen OS, Hemmings HC Jr.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3109-3114. doi: 10.1073/pnas.1611717114. Epub 2017 Mar 6.


Effects of Gabra2 Point Mutations on Alcohol Intake: Increased Binge-Like and Blunted Chronic Drinking by Mice.

Newman EL, Gunner G, Huynh P, Gachette D, Moss SJ, Smart TG, Rudolph U, DeBold JF, Miczek KA.

Alcohol Clin Exp Res. 2016 Nov;40(11):2445-2455. doi: 10.1111/acer.13215. Epub 2016 Sep 26.


Mechanisms of the Immunological Effects of Volatile Anesthetics: A Review.

Yuki K, Eckenhoff RG.

Anesth Analg. 2016 Aug;123(2):326-35. doi: 10.1213/ANE.0000000000001403. Review.


Mechanistic Insights into the Modulation of Voltage-Gated Ion Channels by Inhalational Anesthetics.

Covarrubias M, Barber AF, Carnevale V, Treptow W, Eckenhoff RG.

Biophys J. 2015 Nov 17;109(10):2003-11. doi: 10.1016/j.bpj.2015.09.032. Review.


The molecular pharmacology of volatile anesthetics.

Borghese CM.

Int Anesthesiol Clin. 2015 Spring;53(2):28-39. doi: 10.1097/AIA.0000000000000060. Review. No abstract available.


Volatile anesthetics inhibit sodium channels without altering bulk lipid bilayer properties.

Herold KF, Sanford RL, Lee W, Schultz MF, Ingólfsson HI, Andersen OS, Hemmings HC Jr.

J Gen Physiol. 2014 Dec;144(6):545-60. doi: 10.1085/jgp.201411172. Epub 2014 Nov 10.


Anesthetic agent-specific effects on synaptic inhibition.

MacIver MB.

Anesth Analg. 2014 Sep;119(3):558-69. doi: 10.1213/ANE.0000000000000321.


Isoflurane Induces Transient Anterograde Amnesia through Suppression of Brain-Derived Neurotrophic Factor in Hippocampus.

Cho HJ, Sung YH, Lee SH, Chung JY, Kang JM, Yi JW.

J Korean Neurosurg Soc. 2013 Mar;53(3):139-44. doi: 10.3340/jkns.2013.53.3.139. Epub 2013 Mar 31.


Altered anesthetic sensitivity of mice lacking Ndufs4, a subunit of mitochondrial complex I.

Quintana A, Morgan PG, Kruse SE, Palmiter RD, Sedensky MM.

PLoS One. 2012;7(8):e42904. doi: 10.1371/journal.pone.0042904. Epub 2012 Aug 17.


Mutations M287L and Q266I in the glycine receptor α1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but not the minimal alveolar concentration in knockin mice.

Borghese CM, Xiong W, Oh SI, Ho A, Mihic SJ, Zhang L, Lovinger DM, Homanics GE, Eger EI 2nd, Harris RA.

Anesthesiology. 2012 Oct;117(4):765-71.


Induced changes in protein receptors conferring resistance to anesthetics.

Bertaccini EJ, Trudell JR.

Curr Opin Anaesthesiol. 2012 Aug;25(4):405-10. doi: 10.1097/ACO.0b013e328354fda8. Review.


Isoflurane enhances both fast and slow synaptic inhibition in the hippocampus at amnestic concentrations.

Dai S, Perouansky M, Pearce RA.

Anesthesiology. 2012 Apr;116(4):816-23. doi: 10.1097/ALN.0b013e31824be0e3.


Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols.

Borghese CM, Blednov YA, Quan Y, Iyer SV, Xiong W, Mihic SJ, Zhang L, Lovinger DM, Trudell JR, Homanics GE, Harris RA.

J Pharmacol Exp Ther. 2012 Feb;340(2):304-16. doi: 10.1124/jpet.111.185116. Epub 2011 Oct 28.


Anxiety and depression: mouse genetics and pharmacological approaches to the role of GABA(A) receptor subtypes.

Smith KS, Rudolph U.

Neuropharmacology. 2012 Jan;62(1):54-62. doi: 10.1016/j.neuropharm.2011.07.026. Epub 2011 Jul 27. Review.


GABA(A) receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation.

Olsen RW, Li GD.

Can J Anaesth. 2011 Feb;58(2):206-15. doi: 10.1007/s12630-010-9429-7. Epub 2010 Dec 31. Review.


Testing the silence of mutations: Transcriptomic and behavioral studies of GABA(A) receptor α1 and α2 subunit knock-in mice.

Harris RA, Osterndorff-Kahanek E, Ponomarev I, Homanics GE, Blednov YA.

Neurosci Lett. 2011 Jan 13;488(1):31-5. doi: 10.1016/j.neulet.2010.10.075. Epub 2010 Nov 5.


Loss of ethanol conditioned taste aversion and motor stimulation in knockin mice with ethanol-insensitive α2-containing GABA(A) receptors.

Blednov YA, Borghese CM, McCracken ML, Benavidez JM, Geil CR, Osterndorff-Kahanek E, Werner DF, Iyer S, Swihart A, Harrison NL, Homanics GE, Harris RA.

J Pharmacol Exp Ther. 2011 Jan;336(1):145-54. doi: 10.1124/jpet.110.171645. Epub 2010 Sep 27.

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