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Items: 15

1.

The Crystal Structure of Cytochrome P450 4B1 (CYP4B1) Monooxygenase Complexed with Octane Discloses Several Structural Adaptations for ω-Hydroxylation.

Hsu MH, Baer BR, Rettie AE, Johnson EF.

J Biol Chem. 2017 Mar 31;292(13):5610-5621. doi: 10.1074/jbc.M117.775494. Epub 2017 Feb 6.

2.

Versatile biocatalysis of fungal cytochrome P450 monooxygenases.

Durairaj P, Hur JS, Yun H.

Microb Cell Fact. 2016 Jul 18;15(1):125. doi: 10.1186/s12934-016-0523-6. Review.

3.

Biochemical and Structural Characterization of MycCI, a Versatile P450 Biocatalyst from the Mycinamicin Biosynthetic Pathway.

DeMars MD 2nd, Sheng F, Park SR, Lowell AN, Podust LM, Sherman DH.

ACS Chem Biol. 2016 Sep 16;11(9):2642-54. doi: 10.1021/acschembio.6b00479. Epub 2016 Aug 5.

PMID:
27420774
4.

Fungal cytochrome P450 monooxygenases of Fusarium oxysporum for the synthesis of ω-hydroxy fatty acids in engineered Saccharomyces cerevisiae.

Durairaj P, Malla S, Nadarajan SP, Lee PG, Jung E, Park HH, Kim BG, Yun H.

Microb Cell Fact. 2015 Apr 2;14:45. doi: 10.1186/s12934-015-0228-2.

5.

Steroid hydroxylation by basidiomycete peroxygenases: a combined experimental and computational study.

Babot ED, Del Río JC, Cañellas M, Sancho F, Lucas F, Guallar V, Kalum L, Lund H, Gröbe G, Scheibner K, Ullrich R, Hofrichter M, Martínez AT, Gutiérrez A.

Appl Environ Microbiol. 2015 Jun 15;81(12):4130-42. doi: 10.1128/AEM.00660-15. Epub 2015 Apr 10.

6.

Catabolism of (2E)-4-hydroxy-2-nonenal via ω- and ω-1-oxidation stimulated by ketogenic diet.

Jin Z, Berthiaume JM, Li Q, Henry F, Huang Z, Sadhukhan S, Gao P, Tochtrop GP, Puchowicz MA, Zhang GF.

J Biol Chem. 2014 Nov 14;289(46):32327-38. doi: 10.1074/jbc.M114.602458. Epub 2014 Oct 1.

7.

A highly conserved mycobacterial cholesterol catabolic pathway.

García-Fernández E, Frank DJ, Galán B, Kells PM, Podust LM, García JL, Ortiz de Montellano PR.

Environ Microbiol. 2013 Aug;15(8):2342-59. doi: 10.1111/1462-2920.12108. Epub 2013 Mar 14.

8.

Identification and functional analysis of cytochrome P450 complement in Streptomyces virginiae IBL14.

Li ZZ, Li XF, Yang W, Dong X, Yu J, Zhu SL, Li M, Xie L, Tong WY.

BMC Genomics. 2013 Feb 27;14:130. doi: 10.1186/1471-2164-14-130.

9.

CYP63A2, a catalytically versatile fungal P450 monooxygenase capable of oxidizing higher-molecular-weight polycyclic aromatic hydrocarbons, alkylphenols, and alkanes.

Syed K, Porollo A, Lam YW, Grimmett PE, Yadav JS.

Appl Environ Microbiol. 2013 Apr;79(8):2692-702. doi: 10.1128/AEM.03767-12. Epub 2013 Feb 15.

10.

Substrate recognition by the multifunctional cytochrome P450 MycG in mycinamicin hydroxylation and epoxidation reactions.

Li S, Tietz DR, Rutaganira FU, Kells PM, Anzai Y, Kato F, Pochapsky TC, Sherman DH, Podust LM.

J Biol Chem. 2012 Nov 2;287(45):37880-90. doi: 10.1074/jbc.M112.410340. Epub 2012 Sep 5.

11.

Substrate analog studies of the ω-regiospecificity of Mycobacterium tuberculosis cholesterol metabolizing cytochrome P450 enzymes CYP124A1, CYP125A1 and CYP142A1.

Johnston JB, Singh AA, Clary AA, Chen CK, Hayes PY, Chow S, De Voss JJ, Ortiz de Montellano PR.

Bioorg Med Chem. 2012 Jul 1;20(13):4064-81. doi: 10.1016/j.bmc.2012.05.003. Epub 2012 May 11.

12.

A fungal P450 (CYP5136A3) capable of oxidizing polycyclic aromatic hydrocarbons and endocrine disrupting alkylphenols: role of Trp(129) and Leu(324).

Syed K, Porollo A, Lam YW, Yadav JS.

PLoS One. 2011;6(12):e28286. doi: 10.1371/journal.pone.0028286. Epub 2011 Dec 2.

13.

Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis.

Ouellet H, Johnston JB, de Montellano PR.

Trends Microbiol. 2011 Nov;19(11):530-9. doi: 10.1016/j.tim.2011.07.009. Epub 2011 Sep 15. Review.

14.

Crystallization and preliminary X-ray analysis of CYP153C1 from Novosphingobium aromaticivorans DSM12444.

Zhou R, Huang C, Zhang A, Bell SG, Zhou W, Wong LL.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Aug 1;67(Pt 8):964-7. doi: 10.1107/S174430911102464X. Epub 2011 Jul 27.

15.

Synthesis, metabolic stability and antiviral evaluation of various alkoxyalkyl esters of cidofovir and 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine.

Ruiz J, Beadle JR, Buller RM, Schreiwer J, Prichard MN, Keith KA, Lewis KC, Hostetler KY.

Bioorg Med Chem. 2011 May 1;19(9):2950-8. doi: 10.1016/j.bmc.2011.03.034. Epub 2011 Mar 23.

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