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PRKCQ promotes oncogenic growth and anoikis resistance of a subset of triple-negative breast cancer cells.

Byerly J, Halstead-Nussloch G, Ito K, Katsyv I, Irie HY.

Breast Cancer Res. 2016 Sep 23;18(1):95.


Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer.

Regan Anderson TM, Ma SH, Raj GV, Cidlowski JA, Helle TM, Knutson TP, Krutilina RI, Seagroves TN, Lange CA.

Cancer Res. 2016 Mar 15;76(6):1653-63. doi: 10.1158/0008-5472.CAN-15-2510. Epub 2016 Jan 29.


Protein tyrosine kinase 6 promotes ERBB2-induced mammary gland tumorigenesis in the mouse.

Peng M, Ball-Kell SM, Tyner AL.

Cell Death Dis. 2015 Aug 6;6:e1848. doi: 10.1038/cddis.2015.210.


PTK6 inhibition promotes apoptosis of Lapatinib-resistant Her2(+) breast cancer cells by inducing Bim.

Park SH, Ito K, Olcott W, Katsyv I, Halstead-Nussloch G, Irie HY.

Breast Cancer Res. 2015 Jun 19;17:86. doi: 10.1186/s13058-015-0594-z.


Cancer-Associated Mutations in Breast Tumor Kinase/PTK6 Differentially Affect Enzyme Activity and Substrate Recognition.

Tsui T, Miller WT.

Biochemistry. 2015 May 26;54(20):3173-82. doi: 10.1021/acs.biochem.5b00303. Epub 2015 May 13.


RSK promotes prostate cancer progression in bone through ING3, CKAP2, and PTK6-mediated cell survival.

Yu G, Lee YC, Cheng CJ, Wu CF, Song JH, Gallick GE, Yu-Lee LY, Kuang J, Lin SH.

Mol Cancer Res. 2015 Feb;13(2):348-57. doi: 10.1158/1541-7786.MCR-14-0384-T. Epub 2014 Sep 4.


PTK6/BRK is expressed in the normal mammary gland and activated at the plasma membrane in breast tumors.

Peng M, Emmadi R, Wang Z, Wiley EL, Gann PH, Khan SA, Banerji N, McDonald W, Asztalos S, Pham TN, Tonetti DA, Tyner AL.

Oncotarget. 2014 Aug 15;5(15):6038-48.


Evolution of breast cancer therapeutics: Breast tumour kinase's role in breast cancer and hope for breast tumour kinase targeted therapy.

Hussain HA, Harvey AJ.

World J Clin Oncol. 2014 Aug 10;5(3):299-310. doi: 10.5306/wjco.v5.i3.299. Review.


HIF-1α-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion.

Pires IM, Blokland NJ, Broos AW, Poujade FA, Senra JM, Eccles SA, Span PN, Harvey AJ, Hammond EM.

Cancer Biol Ther. 2014 Oct;15(10):1350-7. doi: 10.4161/cbt.29822. Epub 2014 Jul 14.


PTK6 promotes cancer migration and invasion in pancreatic cancer cells dependent on ERK signaling.

Ono H, Basson MD, Ito H.

PLoS One. 2014 May 1;9(5):e96060. doi: 10.1371/journal.pone.0096060. eCollection 2014.


Protein tyrosine kinase 6 regulates mammary gland tumorigenesis in mouse models.

Peng M, Ball-Kell SM, Franks RR, Xie H, Tyner AL.

Oncogenesis. 2013 Dec 9;2:e81. doi: 10.1038/oncsis.2013.43.


Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression.

Regan Anderson TM, Peacock DL, Daniel AR, Hubbard GK, Lofgren KA, Girard BJ, Schörg A, Hoogewijs D, Wenger RH, Seagroves TN, Lange CA.

Cancer Res. 2013 Sep 15;73(18):5810-20. doi: 10.1158/0008-5472.CAN-13-0523. Epub 2013 Aug 8. Erratum in: Cancer Res. 2013 Nov 1;73(21):6538.


PTK6 activation at the membrane regulates epithelial-mesenchymal transition in prostate cancer.

Zheng Y, Wang Z, Bie W, Brauer PM, Perez White BE, Li J, Nogueira V, Raychaudhuri P, Hay N, Tonetti DA, Macias V, Kajdacsy-Balla A, Tyner AL.

Cancer Res. 2013 Sep 1;73(17):5426-37. doi: 10.1158/0008-5472.CAN-13-0443. Epub 2013 Jul 15. Erratum in: Cancer Res. 2013 Oct 1;73(19):6096.


Protein-tyrosine phosphatase 1B antagonized signaling by insulin-like growth factor-1 receptor and kinase BRK/PTK6 in ovarian cancer cells.

Fan G, Lin G, Lucito R, Tonks NK.

J Biol Chem. 2013 Aug 23;288(34):24923-34. doi: 10.1074/jbc.M113.482737. Epub 2013 Jun 28.


p90 RSK2 mediates antianoikis signals by both transcription-dependent and -independent mechanisms.

Jin L, Li D, Lee JS, Elf S, Alesi GN, Fan J, Kang HB, Wang D, Fu H, Taunton J, Boggon TJ, Tucker M, Gu TL, Chen ZG, Shin DM, Khuri FR, Kang S.

Mol Cell Biol. 2013 Jul;33(13):2574-85. doi: 10.1128/MCB.01677-12. Epub 2013 Apr 22.


Context-specific protein tyrosine kinase 6 (PTK6) signalling in prostate cancer.

Zheng Y, Tyner AL.

Eur J Clin Invest. 2013 Apr;43(4):397-404. doi: 10.1111/eci.12050. Epub 2013 Feb 10. Review.


Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT.

Zheng Y, Gierut J, Wang Z, Miao J, Asara JM, Tyner AL.

Oncogene. 2013 Sep 5;32(36):4304-12. doi: 10.1038/onc.2012.427. Epub 2012 Oct 1.


Targeting protein tyrosine kinase 6 enhances apoptosis of colon cancer cells following DNA damage.

Gierut JJ, Mathur PS, Bie W, Han J, Tyner AL.

Mol Cancer Ther. 2012 Nov;11(11):2311-20. doi: 10.1158/1535-7163.MCT-12-0009. Epub 2012 Sep 18.


Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR.

Li X, Lu Y, Liang K, Hsu JM, Albarracin C, Mills GB, Hung MC, Fan Z.

Oncogene. 2012 Oct 4;31(40):4372-83. doi: 10.1038/onc.2011.608. Epub 2012 Jan 9.

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