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Impact of Aging and Cytomegalovirus on Immunological Response to Influenza Vaccination and Infection.

Merani S, Pawelec G, Kuchel GA, McElhaney JE.

Front Immunol. 2017 Jul 17;8:784. doi: 10.3389/fimmu.2017.00784. eCollection 2017. Review.


Immune Checkpoint Function of CD85j in CD8 T Cell Differentiation and Aging.

Gustafson CE, Qi Q, Hutter-Saunders J, Gupta S, Jadhav R, Newell E, Maecker H, Weyand CM, Goronzy JJ.

Front Immunol. 2017 Jun 14;8:692. doi: 10.3389/fimmu.2017.00692. eCollection 2017.


Cellular immune responses of older adults to four influenza vaccines: Results of a randomized, controlled comparison.

Kumar A, McElhaney JE, Walrond L, Cyr TD, Merani S, Kollmann TR, Halperin SA, Scheifele DW.

Hum Vaccin Immunother. 2017 Sep 2;13(9):2048-2057. doi: 10.1080/21645515.2017.1337615. Epub 2017 Jun 21.


Functionally Diverse NK-Like T Cells Are Effectors and Predictors of Successful Aging.

Michel JJ, Griffin P, Vallejo AN.

Front Immunol. 2016 Nov 24;7:530. eCollection 2016. Review.


Predictors of influenza among older adults in the emergency department.

Lam PP, Coleman BL, Green K, Powis J, Richardson D, Katz K, Borgundvaag B, Smith-Gorvie T, Kwong JC, Bondy SJ, McGeer A.

BMC Infect Dis. 2016 Oct 28;16(1):615.


Immunogenicity of AS03-adjuvanted and non-adjuvanted trivalent inactivated influenza vaccines in elderly adults: A Phase 3, randomized trial and post-hoc correlate of protection analysis.

Ruiz-Palacios GM, Leroux-Roels G, Beran J, Devaster JM, Esen M, Launay O, McElhaney JE, van Essen GA, Benoit A, Claeys C, Dewé W, Durand C, Duval X, Falsey AR, Feldman G, Galtier F, Gervais P, Hwang SJ, McNeil S, Richardus JH, Trofa A, Oostvogels L; Influence65 study group.

Hum Vaccin Immunother. 2016 Dec;12(12):3043-3055. doi: 10.1080/21645515.2016.1219809.


IL-2 and IL-6 cooperate to enhance the generation of influenza-specific CD8 T cells responding to live influenza virus in aged mice and humans.

Zhou X, Hopkins JW, Wang C, Brahmakshatriya V, Swain SL, Kuchel GA, Haynes L, McElhaney JE.

Oncotarget. 2016 Jun 28;7(26):39171-39183. doi: 10.18632/oncotarget.10047.


T-Cell Immunity to Influenza in Older Adults: A Pathophysiological Framework for Development of More Effective Vaccines.

McElhaney JE, Kuchel GA, Zhou X, Swain SL, Haynes L.

Front Immunol. 2016 Feb 25;7:41. doi: 10.3389/fimmu.2016.00041. eCollection 2016. Review.


Age-related differences in polyfunctional T cell responses.

Van Epps P, Banks R, Aung H, Betts MR, Canaday DH.

Immun Ageing. 2014 Oct 23;11:14. doi: 10.1186/1742-4933-11-14. eCollection 2014.


Fast vaccine design and development based on correlates of protection (COPs).

van Els C, Mjaaland S, Næss L, Sarkadi J, Gonczol E, Korsholm KS, Hansen J, de Jonge J, Kersten G, Warner J, Semper A, Kruiswijk C, Oftung F.

Hum Vaccin Immunother. 2014;10(7):1935-48. doi: 10.4161/hv.28639. Review.


Tailored vaccines targeting the elderly using whole inactivated influenza vaccines bearing cytokine immunomodulators.

Khan T, Heffron CL, High KP, Roberts PC.

J Interferon Cytokine Res. 2014 Feb;34(2):129-39. doi: 10.1089/jir.2012.0119. Epub 2013 Oct 8.


Understanding the immune response to seasonal influenza vaccination in older adults: a systems biology approach.

Lambert ND, Ovsyannikova IG, Pankratz VS, Jacobson RM, Poland GA.

Expert Rev Vaccines. 2012 Aug;11(8):985-94. Review.


The unmet need in the elderly: how immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines.

McElhaney JE, Zhou X, Talbot HK, Soethout E, Bleackley RC, Granville DJ, Pawelec G.

Vaccine. 2012 Mar 9;30(12):2060-7. doi: 10.1016/j.vaccine.2012.01.015. Epub 2012 Jan 27. Review.


GLA-SE, a synthetic toll-like receptor 4 agonist, enhances T-cell responses to influenza vaccine in older adults.

Behzad H, Huckriede AL, Haynes L, Gentleman B, Coyle K, Wilschut JC, Kollmann TR, Reed SG, McElhaney JE.

J Infect Dis. 2012 Feb 1;205(3):466-73. doi: 10.1093/infdis/jir769. Epub 2011 Dec 5.


Role of aging on innate responses to viral infections.

Goldstein DR.

J Gerontol A Biol Sci Med Sci. 2012 Mar;67(3):242-6. doi: 10.1093/gerona/glr194. Epub 2011 Oct 31. Review.


Influenza-specific T cells from older people are enriched in the late effector subset and their presence inversely correlates with vaccine response.

Wagar LE, Gentleman B, Pircher H, McElhaney JE, Watts TH.

PLoS One. 2011;6(8):e23698. doi: 10.1371/journal.pone.0023698. Epub 2011 Aug 22.


Efficacy of a vaccine that links viral epitopes to flagellin in protecting aged mice from influenza viral infection.

Leng J, Stout-Delgado HW, Kavita U, Jacobs A, Tang J, Du W, Tussey L, Goldstein DR.

Vaccine. 2011 Oct 19;29(45):8147-55. doi: 10.1016/j.vaccine.2011.08.027. Epub 2011 Aug 18.


Frailty is associated with impairment of vaccine-induced antibody response and increase in post-vaccination influenza infection in community-dwelling older adults.

Yao X, Hamilton RG, Weng NP, Xue QL, Bream JH, Li H, Tian J, Yeh SH, Resnick B, Xu X, Walston J, Fried LP, Leng SX.

Vaccine. 2011 Jul 12;29(31):5015-21. doi: 10.1016/j.vaccine.2011.04.077. Epub 2011 May 10.


Age-related changes in memory and effector T cells responding to influenza A/H3N2 and pandemic A/H1N1 strains in humans.

Zhou X, McElhaney JE.

Vaccine. 2011 Mar 3;29(11):2169-77. doi: 10.1016/j.vaccine.2010.12.029.


CD8+ T cell immunity to 2009 pandemic and seasonal H1N1 influenza viruses.

Scheible K, Zhang G, Baer J, Azadniv M, Lambert K, Pryhuber G, Treanor JJ, Topham DJ.

Vaccine. 2011 Mar 3;29(11):2159-68. doi: 10.1016/j.vaccine.2010.12.073. Epub 2011 Jan 4.

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