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Items: 1 to 20 of 23


Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop.

Cobbaut M, Derua R, Döppler H, Lou HJ, Vandoninck S, Storz P, Turk BE, Seufferlein T, Waelkens E, Janssens V, Van Lint J.

Sci Rep. 2017 Apr 20;7(1):887. doi: 10.1038/s41598-017-00800-w.


Lowered Expression of Tumor Suppressor Candidate MYO1C Stimulates Cell Proliferation, Suppresses Cell Adhesion and Activates AKT.

Visuttijai K, Pettersson J, Mehrbani Azar Y, van den Bout I, Örndal C, Marcickiewicz J, Nilsson S, Hörnquist M, Olsson B, Ejeskär K, Behboudi A.

PLoS One. 2016 Oct 7;11(10):e0164063. doi: 10.1371/journal.pone.0164063. eCollection 2016.


Targeted proteomic approach in prostatic tissue: a panel of potential biomarkers for cancer detection.

Aiello D, Casadonte F, Terracciano R, Damiano R, Savino R, Sindona G, Napoli A.

Oncoscience. 2016 Jul 8;3(7-8):220-241. eCollection 2016.


Kinase-Dependent and -Independent Roles for PTK6 in Colon Cancer.

Mathur PS, Gierut JJ, Guzman G, Xie H, Xicola RM, Llor X, Chastkofsky MI, Perekatt AO, Tyner AL.

Mol Cancer Res. 2016 Jun;14(6):563-73. doi: 10.1158/1541-7786.MCR-15-0450. Epub 2016 Mar 16.


Regulatory roles of conserved phosphorylation sites in the activation T-loop of the MAP kinase ERK1.

Lai S, Pelech S.

Mol Biol Cell. 2016 Mar 15;27(6):1040-50. doi: 10.1091/mbc.E15-07-0527. Epub 2016 Jan 28.


The critical role of Akt in cardiovascular function.

Abeyrathna P, Su Y.

Vascul Pharmacol. 2015 Nov;74:38-48. doi: 10.1016/j.vph.2015.05.008. Epub 2015 May 27. Review.


Cancer-Associated Mutations in Breast Tumor Kinase/PTK6 Differentially Affect Enzyme Activity and Substrate Recognition.

Tsui T, Miller WT.

Biochemistry. 2015 May 26;54(20):3173-82. doi: 10.1021/acs.biochem.5b00303. Epub 2015 May 13.


Posttranslational regulation of Akt in human cancer.

Chan CH, Jo U, Kohrman A, Rezaeian AH, Chou PC, Logothetis C, Lin HK.

Cell Biosci. 2014 Oct 1;4(1):59. doi: 10.1186/2045-3701-4-59. eCollection 2014. Review.


AKT goes cycling.

Mahajan KN, Mahajan NP.

Cancer Control. 2014 Jul;21(3):239-41. No abstract available.


Protein tyrosine kinase 6 regulates mammary gland tumorigenesis in mouse models.

Peng M, Ball-Kell SM, Franks RR, Xie H, Tyner AL.

Oncogenesis. 2013 Dec 9;2:e81. doi: 10.1038/oncsis.2013.43.


Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities.

Lopez SM, Hodgson MC, Packianathan C, Bingol-Ozakpinar O, Uras F, Rosen BP, Agoulnik IU.

Biochem Biophys Res Commun. 2013 Oct 18;440(2):277-82. doi: 10.1016/j.bbrc.2013.09.077. Epub 2013 Sep 23.


PTK6 activation at the membrane regulates epithelial-mesenchymal transition in prostate cancer.

Zheng Y, Wang Z, Bie W, Brauer PM, Perez White BE, Li J, Nogueira V, Raychaudhuri P, Hay N, Tonetti DA, Macias V, Kajdacsy-Balla A, Tyner AL.

Cancer Res. 2013 Sep 1;73(17):5426-37. doi: 10.1158/0008-5472.CAN-13-0443. Epub 2013 Jul 15. Erratum in: Cancer Res. 2013 Oct 1;73(19):6096.


Context-specific protein tyrosine kinase 6 (PTK6) signalling in prostate cancer.

Zheng Y, Tyner AL.

Eur J Clin Invest. 2013 Apr;43(4):397-404. doi: 10.1111/eci.12050. Epub 2013 Feb 10. Review.


Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT.

Zheng Y, Gierut J, Wang Z, Miao J, Asara JM, Tyner AL.

Oncogene. 2013 Sep 5;32(36):4304-12. doi: 10.1038/onc.2012.427. Epub 2012 Oct 1.


PI3K-independent AKT activation in cancers: a treasure trove for novel therapeutics.

Mahajan K, Mahajan NP.

J Cell Physiol. 2012 Sep;227(9):3178-84. doi: 10.1002/jcp.24065. Review.


Global analysis of DNA methylation by Methyl-Capture sequencing reveals epigenetic control of cisplatin resistance in ovarian cancer cell.

Yu W, Jin C, Lou X, Han X, Li L, He Y, Zhang H, Ma K, Zhu J, Cheng L, Lin B.

PLoS One. 2011;6(12):e29450. doi: 10.1371/journal.pone.0029450. Epub 2011 Dec 22.


The Akt signaling pathway: an emerging therapeutic target in malignant melanoma.

Madhunapantula SV, Mosca PJ, Robertson GP.

Cancer Biol Ther. 2011 Dec 15;12(12):1032-49. doi: 10.4161/cbt.12.12.18442. Epub 2011 Dec 15. Review.


Mechanisms of HGF/Met signaling to Brk and Sam68 in breast cancer progression.

Locatelli A, Lofgren KA, Daniel AR, Castro NE, Lange CA.

Horm Cancer. 2012 Apr;3(1-2):14-25. doi: 10.1007/s12672-011-0097-z. Review.


Protein-tyrosine kinase 6 promotes peripheral adhesion complex formation and cell migration by phosphorylating p130 CRK-associated substrate.

Zheng Y, Asara JM, Tyner AL.

J Biol Chem. 2012 Jan 2;287(1):148-58. doi: 10.1074/jbc.M111.298117. Epub 2011 Nov 14.

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