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Items: 1 to 20 of 54


Targeting GPCR-Gβγ-GRK2 signaling as a novel strategy for treating cardiorenal pathologies.

Rudomanova V, Blaxall BC.

Biochim Biophys Acta. 2017 Aug;1863(8):1883-1892. doi: 10.1016/j.bbadis.2017.01.020. Epub 2017 Jan 25. Review.


"Freeze, Don't Move": How to Arrest a Suspect in Heart Failure - A Review on Available GRK2 Inhibitors.

Sorriento D, Ciccarelli M, Cipolletta E, Trimarco B, Iaccarino G.

Front Cardiovasc Med. 2016 Dec 6;3:48. doi: 10.3389/fcvm.2016.00048. eCollection 2016. Review.


Reversal of Ethanol-induced Intoxication by a Novel Modulator of Gβγ Protein Potentiation of the Glycine Receptor.

San Martin L, Cerda F, Jin C, Jimenez V, Yevenes GE, Hernandez T, Nova D, Fuentealba J, Aguayo LG, Guzman L.

J Biol Chem. 2016 Sep 2;291(36):18791-8. doi: 10.1074/jbc.M116.740555. Epub 2016 Jul 11.


G Protein-Coupled Receptor-G-Protein βγ-Subunit Signaling Mediates Renal Dysfunction and Fibrosis in Heart Failure.

Kamal FA, Travers JG, Schafer AE, Ma Q, Devarajan P, Blaxall BC.

J Am Soc Nephrol. 2017 Jan;28(1):197-208. doi: 10.1681/ASN.2015080852. Epub 2016 Jun 13.


The expanding GRK interactome: Implications in cardiovascular disease and potential for therapeutic development.

Hullmann J, Traynham CJ, Coleman RC, Koch WJ.

Pharmacol Res. 2016 Aug;110:52-64. doi: 10.1016/j.phrs.2016.05.008. Epub 2016 May 12. Review.


A peptide of the RGS domain of GRK2 binds and inhibits Gα(q) to suppress pathological cardiac hypertrophy and dysfunction.

Schumacher SM, Gao E, Cohen M, Lieu M, Chuprun JK, Koch WJ.

Sci Signal. 2016 Mar 22;9(420):ra30. doi: 10.1126/scisignal.aae0549.


From Bench to Bedside: New Approaches to Therapeutic Discovery for Heart Failure.

Bernardo BC, Blaxall BC.

Heart Lung Circ. 2016 May;25(5):425-34. doi: 10.1016/j.hlc.2016.01.002. Epub 2016 Jan 19. Review.


Inhibition of G Protein βγ Subunit Signaling Abrogates Nephritis in Lupus-Prone Mice.

Rangel-Moreno J, To JY, Owen T, Goldman BI, Smrcka AV, Anolik JH.

Arthritis Rheumatol. 2016 Sep;68(9):2244-56. doi: 10.1002/art.39673.


Cardiac Fibrosis: The Fibroblast Awakens.

Travers JG, Kamal FA, Robbins J, Yutzey KE, Blaxall BC.

Circ Res. 2016 Mar 18;118(6):1021-40. doi: 10.1161/CIRCRESAHA.115.306565. Review.


Novel Therapeutic Strategies for Reducing Right Heart Failure Associated Mortality in Fibrotic Lung Diseases.

Adegunsoye A, Levy M, Oyenuga O.

Biomed Res Int. 2015;2015:929170. doi: 10.1155/2015/929170. Epub 2015 Oct 25. Review.


Cardiac cAMP: production, hydrolysis, modulation and detection.

Boularan C, Gales C.

Front Pharmacol. 2015 Oct 1;6:203. doi: 10.3389/fphar.2015.00203. eCollection 2015. Review.


Repeated Mu-Opioid Exposure Induces a Novel Form of the Hyperalgesic Priming Model for Transition to Chronic Pain.

Araldi D, Ferrari LF, Levine JD.

J Neurosci. 2015 Sep 9;35(36):12502-17. doi: 10.1523/JNEUROSCI.1673-15.2015.


PAQR3 regulates Golgi vesicle fission and transport via the Gβγ-PKD signaling pathway.

Hewavitharana T, Wedegaertner PB.

Cell Signal. 2015 Dec;27(12):2444-51. doi: 10.1016/j.cellsig.2015.08.017. Epub 2015 Aug 29.


New paradigms in GPCR drug discovery.

Jacobson KA.

Biochem Pharmacol. 2015 Dec 15;98(4):541-55. doi: 10.1016/j.bcp.2015.08.085. Epub 2015 Aug 8. Review.


Ongoing controversies surrounding cardiac remodeling: is it black and white-or rather fifty shades of gray?

Spaich S, Katus HA, Backs J.

Front Physiol. 2015 Jul 22;6:202. doi: 10.3389/fphys.2015.00202. eCollection 2015. Review.


Targeting G protein coupled receptor-related pathways as emerging molecular therapies.

Ghanemi A.

Saudi Pharm J. 2015 Apr;23(2):115-29. doi: 10.1016/j.jsps.2013.07.007. Epub 2013 Aug 13. Review.


G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity.

Stott JB, Povstyan OV, Carr G, Barrese V, Greenwood IA.

Proc Natl Acad Sci U S A. 2015 May 19;112(20):6497-502. doi: 10.1073/pnas.1418605112. Epub 2015 May 4.


Constitutively active signaling by the G protein βγ-subunit mediates intrinsically increased phosphodiesterase-4 activity in human asthmatic airway smooth muscle cells.

Hu A, Diener BL, Josephson MB, Grunstein MM.

PLoS One. 2015 Mar 5;10(3):e0118712. doi: 10.1371/journal.pone.0118712. eCollection 2015.


Paroxetine-mediated GRK2 inhibition reverses cardiac dysfunction and remodeling after myocardial infarction.

Schumacher SM, Gao E, Zhu W, Chen X, Chuprun JK, Feldman AM, Tesmer JJ, Koch WJ.

Sci Transl Med. 2015 Mar 4;7(277):277ra31. doi: 10.1126/scitranslmed.aaa0154.

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