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Variation in CYP2A6 Activity and Personalized Medicine.

Tanner JA, Tyndale RF.

J Pers Med. 2017 Dec 1;7(4). pii: E18. doi: 10.3390/jpm7040018. Review.


Sex Differences in the Expression of Drug-Metabolizing and Transporter Genes in Human Liver.

Yang L, Li Y, Hong H, Chang CW, Guo LW, Lyn-Cook B, Shi L, Ning B.

J Drug Metab Toxicol. 2012;3(3):1000119. doi: 10.4172/2157-7609.1000119. Epub 2012 Jul 10.


Prediction of cytochrome P450-mediated drug clearance in humans based on the measured activities of selected CYPs.

Gao J, Wang J, Gao N, Tian X, Zhou J, Fang Y, Zhang HF, Wen Q, Jia LJ, Zou D, Qiao HL.

Biosci Rep. 2017 Nov 21;37(6). pii: BSR20171161. doi: 10.1042/BSR20171161. Print 2017 Dec 22.


CYP1B1 Activates Wnt/β-Catenin Signaling through Suppression of Herc5-Mediated ISGylation for Protein Degradation on β-Catenin in HeLa Cells.

Park YS, Kwon YJ, Chun YJ.

Toxicol Res. 2017 Jul;33(3):211-218. doi: 10.5487/TR.2017.33.3.211. Epub 2017 Jul 15.


Sequencing the CYP2D6 gene: from variant allele discovery to clinical pharmacogenetic testing.

Yang Y, Botton MR, Scott ER, Scott SA.

Pharmacogenomics. 2017 May;18(7):673-685. doi: 10.2217/pgs-2017-0033. Epub 2017 May 4. Review.


An in vitro system for measuring genotoxicity mediated by human CYP3A4 in Saccharomyces cerevisiae.

Fasullo M, Freedland J, St John N, Cera C, Egner P, Hartog M, Ding X.

Environ Mol Mutagen. 2017 May;58(4):217-227. doi: 10.1002/em.22093. Epub 2017 Apr 24.


Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue.

Plubell DL, Wilmarth PA, Zhao Y, Fenton AM, Minnier J, Reddy AP, Klimek J, Yang X, David LL, Pamir N.

Mol Cell Proteomics. 2017 May;16(5):873-890. doi: 10.1074/mcp.M116.065524. Epub 2017 Mar 21.


Traumatic Brain Injury Induces Genome-Wide Transcriptomic, Methylomic, and Network Perturbations in Brain and Blood Predicting Neurological Disorders.

Meng Q, Zhuang Y, Ying Z, Agrawal R, Yang X, Gomez-Pinilla F.

EBioMedicine. 2017 Feb;16:184-194. doi: 10.1016/j.ebiom.2017.01.046. Epub 2017 Feb 1.


Predictors of Variation in CYP2A6 mRNA, Protein, and Enzyme Activity in a Human Liver Bank: Influence of Genetic and Nongenetic Factors.

Tanner JA, Prasad B, Claw KG, Stapleton P, Chaudhry A, Schuetz EG, Thummel KE, Tyndale RF.

J Pharmacol Exp Ther. 2017 Jan;360(1):129-139. Epub 2016 Nov 4.


Transcriptional Regulation of CYP2D6 Expression.

Pan X, Ning M, Jeong H.

Drug Metab Dispos. 2017 Jan;45(1):42-48. Epub 2016 Oct 3. Review.


The effect of ZnO nanoparticles on liver function in rats.

Tang HQ, Xu M, Rong Q, Jin RW, Liu QJ, Li YL.

Int J Nanomedicine. 2016 Aug 31;11:4275-85. doi: 10.2147/IJN.S109031. eCollection 2016.


Deep sexual dimorphism in adult medaka fish liver highlighted by multi-omic approach.

Qiao Q, Le Manach S, Sotton B, Huet H, Duvernois-Berthet E, Paris A, Duval C, Ponger L, Marie A, Blond A, Mathéron L, Vinh J, Bolbach G, Djediat C, Bernard C, Edery M, Marie B.

Sci Rep. 2016 Aug 26;6:32459. doi: 10.1038/srep32459.


Reconstructing directed gene regulatory network by only gene expression data.

Zhang L, Feng XK, Ng YK, Li SC.

BMC Genomics. 2016 Aug 18;17 Suppl 4:430. doi: 10.1186/s12864-016-2791-2.


Immunohistochemical markers of CYP3A4 and CYP3A7: a new tool towards personalized pharmacotherapy of hepatocellular carcinoma.

Fanni D, Manchia M, Lai F, Gerosa C, Ambu R, Faa G.

Eur J Histochem. 2016 Apr 11;60(2):2614. doi: 10.4081/ejh.2016.2614.


Systems Nutrigenomics Reveals Brain Gene Networks Linking Metabolic and Brain Disorders.

Meng Q, Ying Z, Noble E, Zhao Y, Agrawal R, Mikhail A, Zhuang Y, Tyagi E, Zhang Q, Lee JH, Morselli M, Orozco L, Guo W, Kilts TM, Zhu J, Zhang B, Pellegrini M, Xiao X, Young MF, Gomez-Pinilla F, Yang X.

EBioMedicine. 2016 May;7:157-66. doi: 10.1016/j.ebiom.2016.04.008. Epub 2016 Apr 13.


Challenges, Solutions, and Quality Metrics of Personal Genome Assembly in Advancing Precision Medicine.

Xiao W, Wu L, Yavas G, Simonyan V, Ning B, Hong H.

Pharmaceutics. 2016 Apr 22;8(2). pii: E15. doi: 10.3390/pharmaceutics8020015. Review.


CYP1A2--a novel genetic marker for early aromatase inhibitor response in the treatment of breast cancer patients.

Simonsson M, Veerla S, Markkula A, Rose C, Ingvar C, Jernström H.

BMC Cancer. 2016 Mar 31;16:256. doi: 10.1186/s12885-016-2284-3.


Network-Based Identification and Prioritization of Key Regulators of Coronary Artery Disease Loci.

Zhao Y, Chen J, Freudenberg JM, Meng Q, Rajpal DK, Yang X.

Arterioscler Thromb Vasc Biol. 2016 May;36(5):928-41. doi: 10.1161/ATVBAHA.115.306725. Epub 2016 Mar 10.


Variants in TRIM22 That Affect NOD2 Signaling Are Associated With Very-Early-Onset Inflammatory Bowel Disease.

Li Q, Lee CH, Peters LA, Mastropaolo LA, Thoeni C, Elkadri A, Schwerd T, Zhu J, Zhang B, Zhao Y, Hao K, Dinarzo A, Hoffman G, Kidd BA, Murchie R, Al Adham Z, Guo C, Kotlarz D, Cutz E, Walters TD, Shouval DS, Curran M, Dobrin R, Brodmerkel C, Snapper SB, Klein C, Brumell JH, Hu M, Nanan R, Snanter-Nanan B, Wong M, Le Deist F, Haddad E, Roifman CM, Deslandres C, Griffiths AM, Gaskin KJ, Uhlig HH, Schadt EE, Muise AM.

Gastroenterology. 2016 May;150(5):1196-1207. doi: 10.1053/j.gastro.2016.01.031. Epub 2016 Feb 4.


Interindividual Variability in Cytochrome P450-Mediated Drug Metabolism.

Tracy TS, Chaudhry AS, Prasad B, Thummel KE, Schuetz EG, Zhong XB, Tien YC, Jeong H, Pan X, Shireman LM, Tay-Sontheimer J, Lin YS.

Drug Metab Dispos. 2016 Mar;44(3):343-51. doi: 10.1124/dmd.115.067900. Epub 2015 Dec 17. Review.

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