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Items: 1 to 20 of 31

1.

A programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells.

Saxena P, Heng BC, Bai P, Folcher M, Zulewski H, Fussenegger M.

Nat Commun. 2016 Apr 11;7:11247. doi: 10.1038/ncomms11247.

2.

Association of the IGF1 gene with fasting insulin levels.

Willems SM, Cornes BK, Brody JA, Morrison AC, Lipovich L, Dauriz M, Chen Y, Liu CT, Rybin DV, Gibbs RA, Muzny D, Pankow JS, Psaty BM, Boerwinkle E, Rotter JI, Siscovick DS, Vasan RS, Kaplan RC, Isaacs A, Dupuis J, van Duijn CM, Meigs JB.

Eur J Hum Genet. 2016 Aug;24(9):1337-43. doi: 10.1038/ejhg.2016.4. Epub 2016 Feb 10.

PMID:
26860063
3.

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.

Gaulton KJ, Ferreira T, Lee Y, Raimondo A, Mägi R, Reschen ME, Mahajan A, Locke A, Rayner NW, Robertson N, Scott RA, Prokopenko I, Scott LJ, Green T, Sparso T, Thuillier D, Yengo L, Grallert H, Wahl S, Frånberg M, Strawbridge RJ, Kestler H, Chheda H, Eisele L, Gustafsson S, Steinthorsdottir V, Thorleifsson G, Qi L, Karssen LC, van Leeuwen EM, Willems SM, Li M, Chen H, Fuchsberger C, Kwan P, Ma C, Linderman M, Lu Y, Thomsen SK, Rundle JK, Beer NL, van de Bunt M, Chalisey A, Kang HM, Voight BF, Abecasis GR, Almgren P, Baldassarre D, Balkau B, Benediktsson R, Blüher M, Boeing H, Bonnycastle LL, Bottinger EP, Burtt NP, Carey J, Charpentier G, Chines PS, Cornelis MC, Couper DJ, Crenshaw AT, van Dam RM, Doney AS, Dorkhan M, Edkins S, Eriksson JG, Esko T, Eury E, Fadista J, Flannick J, Fontanillas P, Fox C, Franks PW, Gertow K, Gieger C, Gigante B, Gottesman O, Grant GB, Grarup N, Groves CJ, Hassinen M, Have CT, Herder C, Holmen OL, Hreidarsson AB, Humphries SE, Hunter DJ, Jackson AU, Jonsson A, Jørgensen ME, Jørgensen T, Kao WH, Kerrison ND, Kinnunen L, Klopp N, Kong A, Kovacs P, Kraft P, Kravic J, Langford C, Leander K, Liang L, Lichtner P, Lindgren CM, Lindholm E, Linneberg A, Liu CT, Lobbens S, Luan J, Lyssenko V, Männistö S, McLeod O, Meyer J, Mihailov E, Mirza G, Mühleisen TW, Müller-Nurasyid M, Navarro C, Nöthen MM, Oskolkov NN, Owen KR, Palli D, Pechlivanis S, Peltonen L, Perry JR, Platou CG, Roden M, Ruderfer D, Rybin D, van der Schouw YT, Sennblad B, Sigurðsson G, Stančáková A, Steinbach G, Storm P, Strauch K, Stringham HM, Sun Q, Thorand B, Tikkanen E, Tonjes A, Trakalo J, Tremoli E, Tuomi T, Wennauer R, Wiltshire S, Wood AR, Zeggini E, Dunham I, Birney E, Pasquali L, Ferrer J, Loos RJ, Dupuis J, Florez JC, Boerwinkle E, Pankow JS, van Duijn C, Sijbrands E, Meigs JB, Hu FB, Thorsteinsdottir U, Stefansson K, Lakka TA, Rauramaa R, Stumvoll M, Pedersen NL, Lind L, Keinanen-Kiukaanniemi SM, Korpi-Hyövälti E, Saaristo TE, Saltevo J, Kuusisto J, Laakso M, Metspalu A, Erbel R, Jöcke KH, Moebus S, Ripatti S, Salomaa V, Ingelsson E, Boehm BO, Bergman RN, Collins FS, Mohlke KL, Koistinen H, Tuomilehto J, Hveem K, Njølstad I, Deloukas P, Donnelly PJ, Frayling TM, Hattersley AT, de Faire U, Hamsten A, Illig T, Peters A, Cauchi S, Sladek R, Froguel P, Hansen T, Pedersen O, Morris AD, Palmer CN, Kathiresan S, Melander O, Nilsson PM, Groop LC, Barroso I, Langenberg C, Wareham NJ, O'Callaghan CA, Gloyn AL, Altshuler D, Boehnke M, Teslovich TM, McCarthy MI, Morris AP; DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium.

Nat Genet. 2015 Dec;47(12):1415-25. doi: 10.1038/ng.3437. Epub 2015 Nov 9.

4.

The FOXP1, FOXP2 and FOXP4 transcription factors are required for islet alpha cell proliferation and function in mice.

Spaeth JM, Hunter CS, Bonatakis L, Guo M, French CA, Slack I, Hara M, Fisher SE, Ferrer J, Morrisey EE, Stanger BZ, Stein R.

Diabetologia. 2015 Aug;58(8):1836-44. doi: 10.1007/s00125-015-3635-3. Epub 2015 May 29.

5.

Insm1 cooperates with Neurod1 and Foxa2 to maintain mature pancreatic β-cell function.

Jia S, Ivanov A, Blasevic D, Müller T, Purfürst B, Sun W, Chen W, Poy MN, Rajewsky N, Birchmeier C.

EMBO J. 2015 May 12;34(10):1417-33. doi: 10.15252/embj.201490819. Epub 2015 Mar 31.

6.

Identification of a regulatory variant that binds FOXA1 and FOXA2 at the CDC123/CAMK1D type 2 diabetes GWAS locus.

Fogarty MP, Cannon ME, Vadlamudi S, Gaulton KJ, Mohlke KL.

PLoS Genet. 2014 Sep 11;10(9):e1004633. doi: 10.1371/journal.pgen.1004633. eCollection 2014 Sep.

7.

Building and specializing epithelial tubular organs: the Drosophila salivary gland as a model system for revealing how epithelial organs are specified, form and specialize.

Chung S, Hanlon CD, Andrew DJ.

Wiley Interdiscip Rev Dev Biol. 2014 Jul-Aug;3(4):281-300. doi: 10.1002/wdev.140. Epub 2014 May 23. Review.

8.

Association of levels of fasting glucose and insulin with rare variants at the chromosome 11p11.2-MADD locus: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study.

Cornes BK, Brody JA, Nikpoor N, Morrison AC, Dang HC, Ahn BS, Wang S, Dauriz M, Barzilay JI, Dupuis J, Florez JC, Coresh J, Gibbs RA, Kao WH, Liu CT, McKnight B, Muzny D, Pankow JS, Reid JG, White CC, Johnson AD, Wong TY, Psaty BM, Boerwinkle E, Rotter JI, Siscovick DS, Sladek R, Meigs JB.

Circ Cardiovasc Genet. 2014 Jun;7(3):374-82. doi: 10.1161/CIRCGENETICS.113.000169.

9.

Sequence variation in TMEM18 in association with body mass index: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study.

Liu CT, Young KL, Brody JA, Olden M, Wojczynski MK, Heard-Costa N, Li G, Morrison AC, Muzny D, Gibbs RA, Reid JG, Shao Y, Zhou Y, Boerwinkle E, Heiss G, Wagenknecht L, McKnight B, Borecki IB, Fox CS, North KE, Cupples LA.

Circ Cardiovasc Genet. 2014 Jun;7(3):344-9. doi: 10.1161/CIRCGENETICS.13.000067.

10.

The diabetes gene Hhex maintains δ-cell differentiation and islet function.

Zhang J, McKenna LB, Bogue CW, Kaestner KH.

Genes Dev. 2014 Apr 15;28(8):829-34. doi: 10.1101/gad.235499.113.

11.

Thioredoxin-interacting protein promotes islet amyloid polypeptide expression through miR-124a and FoxA2.

Jing G, Westwell-Roper C, Chen J, Xu G, Verchere CB, Shalev A.

J Biol Chem. 2014 Apr 25;289(17):11807-15. doi: 10.1074/jbc.M113.525022. Epub 2014 Mar 13.

12.

A secretory cell type develops alongside multiciliated cells, ionocytes and goblet cells, and provides a protective, anti-infective function in the frog embryonic mucociliary epidermis.

Dubaissi E, Rousseau K, Lea R, Soto X, Nardeosingh S, Schweickert A, Amaya E, Thornton DJ, Papalopulu N.

Development. 2014 Apr;141(7):1514-25. doi: 10.1242/dev.102426. Epub 2014 Mar 5.

13.

Organ-specific gene expression: the bHLH protein Sage provides tissue specificity to Drosophila FoxA.

Fox RM, Vaishnavi A, Maruyama R, Andrew DJ.

Development. 2013 May;140(10):2160-71. doi: 10.1242/dev.092924. Epub 2013 Apr 11.

14.

Microarray analysis of novel candidate genes responsible for glucose-stimulated insulin secretion in mouse pancreatic β cell line MIN6.

Yamato E, Tashiro F, Miyazaki J.

PLoS One. 2013;8(4):e61211. doi: 10.1371/journal.pone.0061211. Epub 2013 Apr 3.

15.

Multiple functional polymorphisms in the G6PC2 gene contribute to the association with higher fasting plasma glucose levels.

Baerenwald DA, Bonnefond A, Bouatia-Naji N, Flemming BP, Umunakwe OC, Oeser JK, Pound LD, Conley NL, Cauchi S, Lobbens S, Eury E, Balkau B, Lantieri O; MAGIC Investigators, Dadi PK, Jacobson DA, Froguel P, O'Brien RM.

Diabetologia. 2013 Jun;56(6):1306-16. doi: 10.1007/s00125-013-2875-3. Epub 2013 Mar 19.

16.

Neurogenin3 cooperates with Foxa2 to autoactivate its own expression.

Ejarque M, Cervantes S, Pujadas G, Tutusaus A, Sanchez L, Gasa R.

J Biol Chem. 2013 Apr 26;288(17):11705-17. doi: 10.1074/jbc.M112.388173. Epub 2013 Mar 7.

17.

FOXA1 mediates p16(INK4a) activation during cellular senescence.

Li Q, Zhang Y, Fu J, Han L, Xue L, Lv C, Wang P, Li G, Tong T.

EMBO J. 2013 Mar 20;32(6):858-73. doi: 10.1038/emboj.2013.35. Epub 2013 Feb 26.

18.

Forkhead box protein A2 (FOXA2) protein stability and activity are regulated by sumoylation.

Belaguli NS, Zhang M, Brunicardi FC, Berger DH.

PLoS One. 2012;7(10):e48019. doi: 10.1371/journal.pone.0048019. Epub 2012 Oct 31.

19.

Mash1 expression is induced in neuroendocrine prostate cancer upon the loss of Foxa2.

Gupta A, Yu X, Case T, Paul M, Shen MM, Kaestner KH, Matusik RJ.

Prostate. 2013 May;73(6):582-9. doi: 10.1002/pros.22598. Epub 2012 Oct 11.

20.

Activation of the transcription factor carbohydrate-responsive element-binding protein by glucose leads to increased pancreatic beta cell differentiation in rats.

Soggia A, Flosseau K, Ravassard P, Szinnai G, Scharfmann R, Guillemain G.

Diabetologia. 2012 Oct;55(10):2713-22. doi: 10.1007/s00125-012-2623-0. Epub 2012 Jul 5.

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