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Items: 13

1.

Reverse pharmacogenomics: carbamazepine normalizes activation and attenuates thermal hyperexcitability of sensory neurons due to Nav 1.7 mutation I234T.

Yang Y, Adi T, Effraim PR, Chen L, Dib-Hajj SD, Waxman SG.

Br J Pharmacol. 2018 Jun;175(12):2261-2271. doi: 10.1111/bph.13935. Epub 2017 Jul 30.

PMID:
28658526
2.

The AMPK Activator A769662 Blocks Voltage-Gated Sodium Channels: Discovery of a Novel Pharmacophore with Potential Utility for Analgesic Development.

Asiedu MN, Han C, Dib-Hajj SD, Waxman SG, Price TJ, Dussor G.

PLoS One. 2017 Jan 24;12(1):e0169882. doi: 10.1371/journal.pone.0169882. eCollection 2017.

3.

AMPK: An emerging target for modification of injury-induced pain plasticity.

Price TJ, Dussor G.

Neurosci Lett. 2013 Dec 17;557 Pt A:9-18. doi: 10.1016/j.neulet.2013.06.060. Epub 2013 Jul 3. Review.

4.

Proton-dependent inhibition of the cardiac sodium channel Nav1.5 by ranolazine.

Sokolov S, Peters CH, Rajamani S, Ruben PC.

Front Pharmacol. 2013 Jun 21;4:78. doi: 10.3389/fphar.2013.00078. eCollection 2013.

5.

Effects of the antianginal drug, ranolazine, on the brain sodium channel Na(V)1.2 and its modulation by extracellular protons.

Peters CH, Sokolov S, Rajamani S, Ruben PC.

Br J Pharmacol. 2013 Jun;169(3):704-16. doi: 10.1111/bph.12150.

6.

Blocking Scn10a channels in heart reduces late sodium current and is antiarrhythmic.

Yang T, Atack TC, Stroud DM, Zhang W, Hall L, Roden DM.

Circ Res. 2012 Jul 20;111(3):322-32. doi: 10.1161/CIRCRESAHA.112.265173. Epub 2012 Jun 20.

7.

Electrophysiological characteristics of canine superior vena cava sleeve preparations: effect of ranolazine.

Sicouri S, Blazek J, Belardinelli L, Antzelevitch C.

Circ Arrhythm Electrophysiol. 2012 Apr;5(2):371-9. doi: 10.1161/CIRCEP.111.969493. Epub 2012 Mar 9.

8.

Sensitization of dural afferents underlies migraine-related behavior following meningeal application of interleukin-6 (IL-6).

Yan J, Melemedjian OK, Price TJ, Dussor G.

Mol Pain. 2012 Jan 24;8:6. doi: 10.1186/1744-8069-8-6.

9.

Recent developments regarding voltage-gated sodium channel blockers for the treatment of inherited and acquired neuropathic pain syndromes.

Theile JW, Cummins TR.

Front Pharmacol. 2011 Oct 4;2:54. doi: 10.3389/fphar.2011.00054. eCollection 2011.

10.

Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain.

Melemedjian OK, Asiedu MN, Tillu DV, Sanoja R, Yan J, Lark A, Khoutorsky A, Johnson J, Peebles KA, Lepow T, Sonenberg N, Dussor G, Price TJ.

Mol Pain. 2011 Sep 21;7:70. doi: 10.1186/1744-8069-7-70.

11.

Extended-release ranolazine: critical evaluation of its use in stable angina.

Truffa AA, Newby LK, Melloni C.

Vasc Health Risk Manag. 2011;7:535-9. doi: 10.2147/VHRM.S15560. Epub 2011 Aug 25. Review.

12.

Inhibition of NavĪ²4 peptide-mediated resurgent sodium currents in Nav1.7 channels by carbamazepine, riluzole, and anandamide.

Theile JW, Cummins TR.

Mol Pharmacol. 2011 Oct;80(4):724-34. doi: 10.1124/mol.111.072751. Epub 2011 Jul 25.

13.

Nav1.7 is the predominant sodium channel in rodent olfactory sensory neurons.

Ahn HS, Black JA, Zhao P, Tyrrell L, Waxman SG, Dib-Hajj SD.

Mol Pain. 2011 May 10;7:32. doi: 10.1186/1744-8069-7-32.

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