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Items: 18


Silencing of NAC1 Expression Induces Cancer Cells Oxidative Stress in Hypoxia and Potentiates the Therapeutic Activity of Elesclomol.

Ren YJ, Wang XH, Ji C, Guan YD, Lu XJ, Liu XR, Zhang HH, Guo LC, Xu QH, Zhu WD, Ming ZJ, Yang JM, Cheng Y, Zhang Y.

Front Pharmacol. 2017 Nov 7;8:804. doi: 10.3389/fphar.2017.00804. eCollection 2017.


Nucleus accumbens-associated protein-1 promotes glycolysis and survival of hypoxic tumor cells via the HDAC4-HIF-1α axis.

Zhang Y, Ren YJ, Guo LC, Ji C, Hu J, Zhang HH, Xu QH, Zhu WD, Ming ZJ, Yuan YS, Ren X, Song J, Yang JM.

Oncogene. 2017 Jul 20;36(29):4171-4181. doi: 10.1038/onc.2017.51. Epub 2017 Mar 20.


Obstacles Posed by the Tumor Microenvironment to T cell Activity: A Case for Synergistic Therapies.

Anderson KG, Stromnes IM, Greenberg PD.

Cancer Cell. 2017 Mar 13;31(3):311-325. doi: 10.1016/j.ccell.2017.02.008. Review.


Metabolic Regulation of Apoptosis in Cancer.

Matsuura K, Canfield K, Feng W, Kurokawa M.

Int Rev Cell Mol Biol. 2016;327:43-87. doi: 10.1016/bs.ircmb.2016.06.006. Epub 2016 Jul 30. Review.


Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression.

Ventura R, Mordec K, Waszczuk J, Wang Z, Lai J, Fridlib M, Buckley D, Kemble G, Heuer TS.

EBioMedicine. 2015 Jul 2;2(8):808-24. doi: 10.1016/j.ebiom.2015.06.020. eCollection 2015 Aug.


Fatty acid synthase overexpression: target for therapy and reversal of chemoresistance in ovarian cancer.

Bauerschlag DO, Maass N, Leonhardt P, Verburg FA, Pecks U, Zeppernick F, Morgenroth A, Mottaghy FM, Tolba R, Meinhold-Heerlein I, Bräutigam K.

J Transl Med. 2015 May 7;13:146. doi: 10.1186/s12967-015-0511-3.


Up-regulated FASN expression promotes transcoelomic metastasis of ovarian cancer cell through epithelial-mesenchymal transition.

Jiang L, Wang H, Li J, Fang X, Pan H, Yuan X, Zhang P.

Int J Mol Sci. 2014 Jun 27;15(7):11539-54. doi: 10.3390/ijms150711539.


Fatty acid synthase inhibitors induce apoptosis in non-tumorigenic melan-a cells associated with inhibition of mitochondrial respiration.

Rossato FA, Zecchin KG, La Guardia PG, Ortega RM, Alberici LC, Costa RA, Catharino RR, Graner E, Castilho RF, Vercesi AE.

PLoS One. 2014 Jun 25;9(6):e101060. doi: 10.1371/journal.pone.0101060. eCollection 2014.


Aberrant lipid metabolism: an emerging diagnostic and therapeutic target in ovarian cancer.

Pyragius CE, Fuller M, Ricciardelli C, Oehler MK.

Int J Mol Sci. 2013 Apr 10;14(4):7742-56. doi: 10.3390/ijms14047742.


The fatty acid synthase inhibitor orlistat reduces experimental metastases and angiogenesis in B16-F10 melanomas.

Seguin F, Carvalho MA, Bastos DC, Agostini M, Zecchin KG, Alvarez-Flores MP, Chudzinski-Tavassi AM, Coletta RD, Graner E.

Br J Cancer. 2012 Sep 4;107(6):977-87. doi: 10.1038/bjc.2012.355. Epub 2012 Aug 14.


NAC1 is an actin-binding protein that is essential for effective cytokinesis in cancer cells.

Yap KL, Fraley SI, Thiaville MM, Jinawath N, Nakayama K, Wang J, Wang TL, Wirtz D, Shih IeM.

Cancer Res. 2012 Aug 15;72(16):4085-96. doi: 10.1158/0008-5472.CAN-12-0302. Epub 2012 Jul 3.


Fatty acid synthase expression associated with NAC1 is a potential therapeutic target in ovarian clear cell carcinomas.

Rahman MT, Nakayama K, Rahman M, Katagiri H, Katagiri A, Ishibashi T, Ishikawa M, Iida K, Nakayama N, Otsuki Y, Nakayama S, Miyazaki K.

Br J Cancer. 2012 Jul 10;107(2):300-7. doi: 10.1038/bjc.2012.246. Epub 2012 May 31.


Efficacy of a non-hypercalcemic vitamin-D2 derived anti-cancer agent (MT19c) and inhibition of fatty acid synthesis in an ovarian cancer xenograft model.

Moore RG, Lange TS, Robinson K, Kim KK, Uzun A, Horan TC, Kawar N, Yano N, Chu SR, Mao Q, Brard L, DePaepe ME, Padbury JF, Arnold LA, Brodsky A, Shen TL, Singh RK.

PLoS One. 2012;7(4):e34443. doi: 10.1371/journal.pone.0034443. Epub 2012 Apr 3.


Tumor cell metabolism: an integral view.

Romero-Garcia S, Lopez-Gonzalez JS, Báez-Viveros JL, Aguilar-Cazares D, Prado-Garcia H.

Cancer Biol Ther. 2011 Dec 1;12(11):939-48. doi: 10.4161/cbt.12.11.18140. Epub 2011 Dec 1. Review.


Diagnosis of serous tubal intraepithelial carcinoma based on morphologic and immunohistochemical features: a reproducibility study.

Visvanathan K, Vang R, Shaw P, Gross A, Soslow R, Parkash V, Shih IeM, Kurman RJ.

Am J Surg Pathol. 2011 Dec;35(12):1766-75. doi: 10.1097/PAS.0b013e31822f58bc.


Overexpression of fatty acid synthase in Middle Eastern epithelial ovarian carcinoma activates AKT and Its inhibition potentiates cisplatin-induced apoptosis.

Uddin S, Jehan Z, Ahmed M, Alyan A, Al-Dayel F, Hussain A, Bavi P, Al-Kuraya KS.

Mol Med. 2011;17(7-8):635-45. doi: 10.2119/molmed.2011.00046. Epub 2011 Mar 21.


Amplification of the ch19p13.2 NACC1 locus in ovarian high-grade serous carcinoma.

Shih IeM, Nakayama K, Wu G, Nakayama N, Zhang J, Wang TL.

Mod Pathol. 2011 May;24(5):638-45. doi: 10.1038/modpathol.2010.230. Epub 2011 Jan 14.

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