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Items: 1 to 20 of 33


From structure to mechanism-understanding initiation of DNA replication.

Riera A, Barbon M, Noguchi Y, Reuter LM, Schneider S, Speck C.

Genes Dev. 2017 Jun 1;31(11):1073-1088. doi: 10.1101/gad.298232.117. Review.


Eukaryotic Replicative Helicase Subunit Interaction with DNA and Its Role in DNA Replication.

Martinez MP, Wacker AL, Bruck I, Kaplan DL.

Genes (Basel). 2017 Apr 6;8(4). pii: E117. doi: 10.3390/genes8040117. Review.


Origin DNA Melting-An Essential Process with Divergent Mechanisms.

Martinez MP, Jones JM, Bruck I, Kaplan DL.

Genes (Basel). 2017 Jan 11;8(1). pii: E26. doi: 10.3390/genes8010026. Review.


Regulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome Stability.

Pozo PN, Cook JG.

Genes (Basel). 2016 Dec 22;8(1). pii: E2. doi: 10.3390/genes8010002. Review.


Mechanisms Governing DDK Regulation of the Initiation of DNA Replication.

Larasati, Duncker BP.

Genes (Basel). 2016 Dec 22;8(1). pii: E3. doi: 10.3390/genes8010003. Review.


Molecular mechanisms of substrate-controlled ring dynamics and substepping in a nucleic acid-dependent hexameric motor.

Thomsen ND, Lawson MR, Witkowsky LB, Qu S, Berger JM.

Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):E7691-E7700. Epub 2016 Nov 16.


An Mcm10 Mutant Defective in ssDNA Binding Shows Defects in DNA Replication Initiation.

Perez-Arnaiz P, Kaplan DL.

J Mol Biol. 2016 Nov 20;428(23):4608-4625. doi: 10.1016/j.jmb.2016.10.014. Epub 2016 Oct 15.


A Checkpoint-Related Function of the MCM Replicative Helicase Is Required to Avert Accumulation of RNA:DNA Hybrids during S-phase and Ensuing DSBs during G2/M.

Vijayraghavan S, Tsai FL, Schwacha A.

PLoS Genet. 2016 Aug 24;12(8):e1006277. doi: 10.1371/journal.pgen.1006277. eCollection 2016 Aug.


The eukaryotic CMG helicase pumpjack and integration into the replisome.

Sun J, Yuan Z, Georgescu R, Li H, O'Donnell M.

Nucleus. 2016 Apr 25;7(2):146-54. doi: 10.1080/19491034.2016.1174800. Review.


Structural Mechanisms of Hexameric Helicase Loading, Assembly, and Unwinding.

Trakselis MA.

F1000Res. 2016 Jan 27;5. pii: F1000 Faculty Rev-111. doi: 10.12688/f1000research.7509.1. eCollection 2016. Review.


Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication.

Chang F, Riera A, Evrin C, Sun J, Li H, Speck C, Weinreich M.

Elife. 2015 Aug 25;4. doi: 10.7554/eLife.05795.


Mcm2-7 Is an Active Player in the DNA Replication Checkpoint Signaling Cascade via Proposed Modulation of Its DNA Gate.

Tsai FL, Vijayraghavan S, Prinz J, MacAlpine HK, MacAlpine DM, Schwacha A.

Mol Cell Biol. 2015 Jun;35(12):2131-43. doi: 10.1128/MCB.01357-14. Epub 2015 Apr 13.


Dpb11 protein helps control assembly of the Cdc45·Mcm2-7·GINS replication fork helicase.

Dhingra N, Bruck I, Smith S, Ning B, Kaplan DL.

J Biol Chem. 2015 Mar 20;290(12):7586-601. doi: 10.1074/jbc.M115.640383. Epub 2015 Feb 6.


The Dbf4-Cdc7 kinase promotes Mcm2-7 ring opening to allow for single-stranded DNA extrusion and helicase assembly.

Bruck I, Kaplan DL.

J Biol Chem. 2015 Jan 9;290(2):1210-21. doi: 10.1074/jbc.M114.608232. Epub 2014 Dec 3. Retraction in: J Biol Chem. 2017 Jun 16;292(24):10320.


Structural and mechanistic insights into Mcm2-7 double-hexamer assembly and function.

Sun J, Fernandez-Cid A, Riera A, Tognetti S, Yuan Z, Stillman B, Speck C, Li H.

Genes Dev. 2014 Oct 15;28(20):2291-303. doi: 10.1101/gad.242313.114.


The Mcm2-7 replicative helicase: a promising chemotherapeutic target.

Simon NE, Schwacha A.

Biomed Res Int. 2014;2014:549719. doi: 10.1155/2014/549719. Epub 2014 Aug 28. Review.


Geminin inhibits a late step in the formation of human pre-replicative complexes.

Wu M, Lu W, Santos RE, Frattini MG, Kelly TJ.

J Biol Chem. 2014 Oct 31;289(44):30810-21. doi: 10.1074/jbc.M114.552935. Epub 2014 Sep 17.


Multiple functions for Mcm2-7 ATPase motifs during replication initiation.

Kang S, Warner MD, Bell SP.

Mol Cell. 2014 Sep 4;55(5):655-65. doi: 10.1016/j.molcel.2014.06.033. Epub 2014 Jul 31.


A unique DNA entry gate serves for regulated loading of the eukaryotic replicative helicase MCM2-7 onto DNA.

Samel SA, Fernández-Cid A, Sun J, Riera A, Tognetti S, Herrera MC, Li H, Speck C.

Genes Dev. 2014 Aug 1;28(15):1653-66. doi: 10.1101/gad.242404.114.


Mechanism of asymmetric polymerase assembly at the eukaryotic replication fork.

Georgescu RE, Langston L, Yao NY, Yurieva O, Zhang D, Finkelstein J, Agarwal T, O'Donnell ME.

Nat Struct Mol Biol. 2014 Aug;21(8):664-70. doi: 10.1038/nsmb.2851. Epub 2014 Jul 6.

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