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Epigenetic assays for chemical biology and drug discovery.

Gul S.

Clin Epigenetics. 2017 Apr 21;9:41. doi: 10.1186/s13148-017-0342-6. eCollection 2017. Review.


The Ecstasy and Agony of Assay Interference Compounds.

Aldrich C, Bertozzi C, Georg GI, Kiessling L, Lindsley C, Liotta D, Merz KM Jr, Schepartz A, Wang S.

ACS Med Chem Lett. 2017 Feb 28;8(4):379-382. doi: 10.1021/acsmedchemlett.7b00056. eCollection 2017 Apr 13. No abstract available.


The Ecstasy and Agony of Assay Interference Compounds.

Aldrich C, Bertozzi C, Georg GI, Kiessling L, Lindsley C, Liotta D, Merz KM Jr, Schepartz A, Wang S.

ACS Cent Sci. 2017 Mar 22;3(3):143-147. doi: 10.1021/acscentsci.7b00069. Epub 2017 Feb 28. No abstract available.


Phantom PAINS: Problems with the Utility of Alerts for Pan-Assay INterference CompoundS.

Capuzzi SJ, Muratov EN, Tropsha A.

J Chem Inf Model. 2017 Mar 27;57(3):417-427. doi: 10.1021/acs.jcim.6b00465. Epub 2017 Feb 25.


Comment on "On the Utility of ToxCastâ„¢ and ToxPi as Methods for Identifying New Obesogens".

Houck KA, Judson RS, Knudsen TB, Martin MT, Richard AM, Crofton KM, Simeonov A, Paules RS, Bucher JR, Thomas RS.

Environ Health Perspect. 2017 Jan 1;125(1):A8-A11. doi: 10.1289/EHP881. No abstract available.


Development and Validation of a Computational Model for Androgen Receptor Activity.

Kleinstreuer NC, Ceger P, Watt ED, Martin M, Houck K, Browne P, Thomas RS, Casey WM, Dix DJ, Allen D, Sakamuru S, Xia M, Huang R, Judson R.

Chem Res Toxicol. 2017 Apr 17;30(4):946-964. doi: 10.1021/acs.chemrestox.6b00347. Epub 2016 Dec 9.


Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles.

Williamson AE, Ylioja PM, Robertson MN, Antonova-Koch Y, Avery V, Baell JB, Batchu H, Batra S, Burrows JN, Bhattacharyya S, Calderon F, Charman SA, Clark J, Crespo B, Dean M, Debbert SL, Delves M, Dennis AS, Deroose F, Duffy S, Fletcher S, Giaever G, Hallyburton I, Gamo FJ, Gebbia M, Guy RK, Hungerford Z, Kirk K, Lafuente-Monasterio MJ, Lee A, Meister S, Nislow C, Overington JP, Papadatos G, Patiny L, Pham J, Ralph SA, Ruecker A, Ryan E, Southan C, Srivastava K, Swain C, Tarnowski MJ, Thomson P, Turner P, Wallace IM, Wells TN, White K, White L, Willis P, Winzeler EA, Wittlin S, Todd MH.

ACS Cent Sci. 2016 Oct 26;2(10):687-701. Epub 2016 Sep 14.


Botanicals and Their Bioactive Phytochemicals for Women's Health.

Dietz BM, Hajirahimkhan A, Dunlap TL, Bolton JL.

Pharmacol Rev. 2016 Oct;68(4):1026-1073. Review.


Cell-based high-throughput screening identifies galactocerebrosidase enhancers as potential small-molecule therapies for Krabbe's disease.

Jang DS, Ye W, Guimei T, Solomon M, Southall N, Hu X, Marugan J, Ferrer M, Maegawa GH.

J Neurosci Res. 2016 Nov;94(11):1231-45. doi: 10.1002/jnr.23875.


Bioluminescence: a versatile technique for imaging cellular and molecular features.

Paley MA, Prescher JA.

Medchemcomm. 2014 Mar 1;5(3):255-267. Epub 2013 Dec 13.


Development and utility of an in vitro, fluorescence-based assay for the discovery of novel compounds against dengue 2 viral protease.

Ulanday GE, Okamoto K, Morita K.

Trop Med Health. 2016 Aug 10;44:22. doi: 10.1186/s41182-016-0025-6. eCollection 2016.


High-Throughput Phenotypic Screening of Human Astrocytes to Identify Compounds That Protect Against Oxidative Stress.

Thorne N, Malik N, Shah S, Zhao J, Class B, Aguisanda F, Southall N, Xia M, McKew JC, Rao M, Zheng W.

Stem Cells Transl Med. 2016 May;5(5):613-27. doi: 10.5966/sctm.2015-0170. Epub 2016 Mar 31.


Docking Screens for Novel Ligands Conferring New Biology.

Irwin JJ, Shoichet BK.

J Med Chem. 2016 May 12;59(9):4103-20. doi: 10.1021/acs.jmedchem.5b02008. Epub 2016 Mar 15.


Tiered High-Throughput Screening Approach to Identify Thyroperoxidase Inhibitors Within the ToxCast Phase I and II Chemical Libraries.

Paul Friedman K, Watt ED, Hornung MW, Hedge JM, Judson RS, Crofton KM, Houck KA, Simmons SO.

Toxicol Sci. 2016 May;151(1):160-80. doi: 10.1093/toxsci/kfw034. Epub 2016 Feb 15.


Stable Colloidal Drug Aggregates Catch and Release Active Enzymes.

McLaughlin CK, Duan D, Ganesh AN, Torosyan H, Shoichet BK, Shoichet MS.

ACS Chem Biol. 2016 Apr 15;11(4):992-1000. doi: 10.1021/acschembio.5b00806. Epub 2016 Jan 15.


Selecting, Acquiring, and Using Small Molecule Libraries for High-Throughput Screening.

Dandapani S, Rosse G, Southall N, Salvino JM, Thomas CJ.

Curr Protoc Chem Biol. 2012;4:177-191. Epub 2012 Sep 1.


A novel quantitative high-throughput screen identifies drugs that both activate SUMO conjugation via the inhibition of microRNAs 182 and 183 and facilitate neuroprotection in a model of oxygen and glucose deprivation.

Bernstock JD, Lee YJ, Peruzzotti-Jametti L, Southall N, Johnson KR, Maric D, Volpe G, Kouznetsova J, Zheng W, Pluchino S, Hallenbeck JM.

J Cereb Blood Flow Metab. 2016 Feb;36(2):426-41. doi: 10.1177/0271678X15609939. Epub 2015 Oct 23.


First-in-Class Inhibitors of Sulfur Metabolism with Bactericidal Activity against Non-Replicating M. tuberculosis.

Palde PB, Bhaskar A, Pedró Rosa LE, Madoux F, Chase P, Gupta V, Spicer T, Scampavia L, Singh A, Carroll KS.

ACS Chem Biol. 2016 Jan 15;11(1):172-84. doi: 10.1021/acschembio.5b00517. Epub 2015 Nov 11.


Can Invalid Bioactives Undermine Natural Product-Based Drug Discovery?

Bisson J, McAlpine JB, Friesen JB, Chen SN, Graham J, Pauli GF.

J Med Chem. 2016 Mar 10;59(5):1671-90. doi: 10.1021/acs.jmedchem.5b01009. Epub 2015 Oct 27. Review.


Integrated Model of Chemical Perturbations of a Biological Pathway Using 18 In Vitro High-Throughput Screening Assays for the Estrogen Receptor.

Judson RS, Magpantay FM, Chickarmane V, Haskell C, Tania N, Taylor J, Xia M, Huang R, Rotroff DM, Filer DL, Houck KA, Martin MT, Sipes N, Richard AM, Mansouri K, Setzer RW, Knudsen TB, Crofton KM, Thomas RS.

Toxicol Sci. 2015 Nov;148(1):137-54. doi: 10.1093/toxsci/kfv168. Epub 2015 Aug 13.

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