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Items: 1 to 20 of 126


SOCS1 regulates senescence and ferroptosis by modulating the expression of p53 target genes.

Saint-Germain E, Mignacca L, Vernier M, Bobbala D, Ilangumaran S, Ferbeyre G.

Aging (Albany NY). 2017 Oct 28;9(10):2137-2162. doi: 10.18632/aging.101306.


Pan-cancer transcriptomic analysis associates long non-coding RNAs with key mutational driver events.

Ashouri A, Sayin VI, Van den Eynden J, Singh SX, Papagiannakopoulos T, Larsson E.

Nat Commun. 2016 Oct 25;7:13197. doi: 10.1038/ncomms13197.


ATRX is a regulator of therapy induced senescence in human cells.

Kovatcheva M, Liao W, Klein ME, Robine N, Geiger H, Crago AM, Dickson MA, Tap WD, Singer S, Koff A.

Nat Commun. 2017 Aug 30;8(1):386. doi: 10.1038/s41467-017-00540-5.


Chromatin-Associated Protein SIN3B Prevents Prostate Cancer Progression by Inducing Senescence.

Bainor AJ, Deng FM, Wang Y, Lee P, Cantor DJ, Logan SK, David G.

Cancer Res. 2017 Oct 1;77(19):5339-5348. doi: 10.1158/0008-5472.CAN-16-3410. Epub 2017 Aug 14.


p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling.

Yosef R, Pilpel N, Papismadov N, Gal H, Ovadya Y, Vadai E, Miller S, Porat Z, Ben-Dor S, Krizhanovsky V.

EMBO J. 2017 Aug 1;36(15):2280-2295. doi: 10.15252/embj.201695553. Epub 2017 Jun 12.


Senoptosis: non-lethal DNA cleavage as a route to deep senescence.

Studencka M, Schaber J.

Oncotarget. 2017 May 9;8(19):30656-30671. doi: 10.18632/oncotarget.15693.


p16 controls epithelial cell growth and suppresses carcinogenesis through mechanisms that do not require RB1 function.

Sen M, Akeno N, Reece A, Miller AL, Simpson DS, Wikenheiser-Brokamp KA.

Oncogenesis. 2017 Apr 17;6(4):e320. doi: 10.1038/oncsis.2017.5.


Progress with palbociclib in breast cancer: latest evidence and clinical considerations.

Rocca A, Schirone A, Maltoni R, Bravaccini S, Cecconetto L, Farolfi A, Bronte G, Andreis D.

Ther Adv Med Oncol. 2017 Feb;9(2):83-105. doi: 10.1177/1758834016677961. Epub 2016 Nov 21. Review.


Roles of pRB in the Regulation of Nucleosome and Chromatin Structures.

Uchida C.

Biomed Res Int. 2016;2016:5959721. doi: 10.1155/2016/5959721. Epub 2016 Dec 22. Review.


Palbociclib (PD-0332991), a selective CDK4/6 inhibitor, restricts tumour growth in preclinical models of hepatocellular carcinoma.

Bollard J, Miguela V, Ruiz de Galarreta M, Venkatesh A, Bian CB, Roberto MP, Tovar V, Sia D, Molina-Sánchez P, Nguyen CB, Nakagawa S, Llovet JM, Hoshida Y, Lujambio A.

Gut. 2017 Jul;66(7):1286-1296. doi: 10.1136/gutjnl-2016-312268. Epub 2016 Nov 14.


MDM2 but not MDM4 promotes retinoblastoma cell proliferation through p53-independent regulation of MYCN translation.

Qi DL, Cobrinik D.

Oncogene. 2017 Mar 30;36(13):1760-1769. doi: 10.1038/onc.2016.350. Epub 2016 Oct 17.


Complex cis-regulatory landscape of the insulin receptor gene underlies the broad expression of a central signaling regulator.

Wei Y, Gokhale RH, Sonnenschein A, Montgomery KM, Ingersoll A, Arnosti DN.

Development. 2016 Oct 1;143(19):3591-3603.


A gene expression signature of retinoblastoma loss-of-function is a predictive biomarker of resistance to palbociclib in breast cancer cell lines and is prognostic in patients with ER positive early breast cancer.

Malorni L, Piazza S, Ciani Y, Guarducci C, Bonechi M, Biagioni C, Hart CD, Verardo R, Di Leo A, Migliaccio I.

Oncotarget. 2016 Sep 13;7(42):68012-68022. doi: 10.18632/oncotarget.12010.


Structural Conservation and E2F Binding Specificity within the Retinoblastoma Pocket Protein Family.

Liban TJ, Thwaites MJ, Dick FA, Rubin SM.

J Mol Biol. 2016 Oct 9;428(20):3960-3971. doi: 10.1016/j.jmb.2016.08.017. Epub 2016 Aug 25.


Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence.

Marthandan S, Menzel U, Priebe S, Groth M, Guthke R, Platzer M, Hemmerich P, Kaether C, Diekmann S.

Biol Res. 2016 Jul 28;49(1):34. doi: 10.1186/s40659-016-0095-2.


RB1: a prototype tumor suppressor and an enigma.

Dyson NJ.

Genes Dev. 2016 Jul 1;30(13):1492-502. doi: 10.1101/gad.282145.116. Review.


Integration of TP53, DREAM, MMB-FOXM1 and RB-E2F target gene analyses identifies cell cycle gene regulatory networks.

Fischer M, Grossmann P, Padi M, DeCaprio JA.

Nucleic Acids Res. 2016 Jul 27;44(13):6070-86. doi: 10.1093/nar/gkw523. Epub 2016 Jun 8.


BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance.

Tasdemir N, Banito A, Roe JS, Alonso-Curbelo D, Camiolo M, Tschaharganeh DF, Huang CH, Aksoy O, Bolden JE, Chen CC, Fennell M, Thapar V, Chicas A, Vakoc CR, Lowe SW.

Cancer Discov. 2016 Jun;6(6):612-29. doi: 10.1158/2159-8290.CD-16-0217. Epub 2016 Apr 20.

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