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Items: 20


Kappa-Opioid Antagonists for Psychiatric Disorders: From Bench to Clinical Trials.

Carlezon WA Jr, Krystal AD.

Depress Anxiety. 2016 Oct;33(10):895-906. doi: 10.1002/da.22500.


Kappa Opioids, Salvinorin A and Major Depressive Disorder.

Taylor GT, Manzella F.

Curr Neuropharmacol. 2016;14(2):165-76. Review.


Naltrexone alters the processing of social and emotional stimuli in healthy adults.

Wardle MC, Bershad AK, de Wit H.

Soc Neurosci. 2016 Dec;11(6):579-91. doi: 10.1080/17470919.2015.1136355. Epub 2016 Jan 22.


The role of the dynorphin/κ opioid receptor system in anxiety.

Hang A, Wang YJ, He L, Liu JG.

Acta Pharmacol Sin. 2015 Jul;36(7):783-90. doi: 10.1038/aps.2015.32. Epub 2015 May 18. Review.


Buprenorphine, methadone, and morphine treatment during pregnancy: behavioral effects on the offspring in rats.

Chen HH, Chiang YC, Yuan ZF, Kuo CC, Lai MD, Hung TW, Ho IK, Chen ST.

Neuropsychiatr Dis Treat. 2015 Mar 6;11:609-18. doi: 10.2147/NDT.S70585. eCollection 2015.


Determining pharmacological selectivity of the kappa opioid receptor antagonist LY2456302 using pupillometry as a translational biomarker in rat and human.

Rorick-Kehn LM, Witcher JW, Lowe SL, Gonzales CR, Weller MA, Bell RL, Hart JC, Need AB, McKinzie JH, Statnick MA, Suico JG, McKinzie DL, Tauscher-Wisniewski S, Mitch CH, Stoltz RR, Wong CJ.

Int J Neuropsychopharmacol. 2014 Oct 31;18(2). pii: pyu036. doi: 10.1093/ijnp/pyu036.


Stress and Drug Dependence Differentially Modulate Norepinephrine Signaling in Animals with Varied HPA Axis Function.

Fox ME, Studebaker RI, Swofford NJ, Wightman RM.

Neuropsychopharmacology. 2015 Jun;40(7):1752-61. doi: 10.1038/npp.2015.23. Epub 2015 Jan 20.


Antidepressant-like effects of buprenorphine in rats are strain dependent.

Browne CA, van Nest DS, Lucki I.

Behav Brain Res. 2015 Feb 1;278:385-92. doi: 10.1016/j.bbr.2014.10.014. Epub 2014 Oct 18.


Effects of buprenorphine on behavioral tests for antidepressant and anxiolytic drugs in mice.

Falcon E, Maier K, Robinson SA, Hill-Smith TE, Lucki I.

Psychopharmacology (Berl). 2015 Mar;232(5):907-15. doi: 10.1007/s00213-014-3723-y. Epub 2014 Sep 3.


Repeated stress exposure causes strain-dependent shifts in the behavioral economics of cocaine in rats.

Groblewski PA, Zietz C, Willuhn I, Phillips PE, Chavkin C.

Addict Biol. 2015 Mar;20(2):297-301. doi: 10.1111/adb.12123. Epub 2014 Feb 15.


Potentiation of GluN2C/D NMDA receptor subtypes in the amygdala facilitates the retention of fear and extinction learning in mice.

Ogden KK, Khatri A, Traynelis SF, Heldt SA.

Neuropsychopharmacology. 2014 Feb;39(3):625-37. doi: 10.1038/npp.2013.241. Epub 2013 Sep 6.


Role of kappa-opioid receptors in stress and anxiety-related behavior.

Van't Veer A, Carlezon WA Jr.

Psychopharmacology (Berl). 2013 Oct;229(3):435-52. doi: 10.1007/s00213-013-3195-5. Epub 2013 Jul 9. Review.


Ablation of kappa-opioid receptors from brain dopamine neurons has anxiolytic-like effects and enhances cocaine-induced plasticity.

Van't Veer A, Bechtholt AJ, Onvani S, Potter D, Wang Y, Liu-Chen LY, Schütz G, Chartoff EH, Rudolph U, Cohen BM, Carlezon WA Jr.

Neuropsychopharmacology. 2013 Jul;38(8):1585-97. doi: 10.1038/npp.2013.58. Epub 2013 Feb 27.


Development of κ opioid receptor antagonists.

Carroll FI, Carlezon WA Jr.

J Med Chem. 2013 Mar 28;56(6):2178-95. doi: 10.1021/jm301783x. Epub 2013 Feb 14. Review.


Effects of a post-shock injection of the kappa opioid receptor antagonist norbinaltorphimine (norBNI) on fear and anxiety in rats.

Rogala B, Li Y, Li S, Chen X, Kirouac GJ.

PLoS One. 2012;7(11):e49669. doi: 10.1371/journal.pone.0049669. Epub 2012 Nov 14.


Sex differences in U50,488H-induced phosphorylation of p44/42 mitogen-activated protein kinase in the guinea pig brain.

Rasakham K, McGillivray KL, Liu-Chen LY.

Neuroscience. 2012 Oct 25;223:447-56. doi: 10.1016/j.neuroscience.2012.07.040. Epub 2012 Jul 31.


Stress-induced epigenetic regulation of κ-opioid receptor gene involves transcription factor c-Myc.

Flaisher-Grinberg S, Persaud SD, Loh HH, Wei LN.

Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9167-72. doi: 10.1073/pnas.1205565109. Epub 2012 May 21.


Sex difference in κ-opioid receptor (KOPR)-mediated behaviors, brain region KOPR level and KOPR-mediated guanosine 5'-O-(3-[35S]thiotriphosphate) binding in the guinea pig.

Wang YJ, Rasakham K, Huang P, Chudnovskaya D, Cowan A, Liu-Chen LY.

J Pharmacol Exp Ther. 2011 Nov;339(2):438-50. doi: 10.1124/jpet.111.183905. Epub 2011 Aug 12.


Kappa opioid receptor signaling in the basolateral amygdala regulates conditioned fear and anxiety in rats.

Knoll AT, Muschamp JW, Sillivan SE, Ferguson D, Dietz DM, Meloni EG, Carroll FI, Nestler EJ, Konradi C, Carlezon WA Jr.

Biol Psychiatry. 2011 Sep 1;70(5):425-33. doi: 10.1016/j.biopsych.2011.03.017. Epub 2011 Apr 30.


Sex differences in kappa opioid pharmacology.

Rasakham K, Liu-Chen LY.

Life Sci. 2011 Jan 3;88(1-2):2-16. doi: 10.1016/j.lfs.2010.10.007. Epub 2010 Oct 14. Review.

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