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Items: 6


Cheminformatic comparison of approved drugs from natural product versus synthetic origins.

Stratton CF, Newman DJ, Tan DS.

Bioorg Med Chem Lett. 2015 Nov 1;25(21):4802-7. doi: 10.1016/j.bmcl.2015.07.014. Epub 2015 Jul 14.


Parallel and four-step synthesis of natural-product-inspired scaffolds through modular assembly and divergent cyclization.

Oguri H, Mizoguchi H, Oikawa H, Ishiyama A, Iwatsuki M, Otoguro K, Omura S.

Beilstein J Org Chem. 2012;8:930-40. Epub 2012 Jun 22.


Synthesis and profiling of a diverse collection of azetidine-based scaffolds for the development of CNS-focused lead-like libraries.

Lowe JT, Lee MD 4th, Akella LB, Davoine E, Donckele EJ, Durak L, Duvall JR, Gerard B, Holson EB, Joliton A, Kesavan S, Lemercier BC, Liu H, MariƩ JC, Mulrooney CA, Muncipinto G, Welzel-O'Shea M, Panko LM, Rowley A, Suh BC, Thomas M, Wagner FF, Wei J, Foley MA, Marcaurelle LA.

J Org Chem. 2012 Sep 7;77(17):7187-211. doi: 10.1021/jo300974j. Epub 2012 Aug 10.


Synthesis of a unique isoindoline/tetrahydroisoquinoline-based tricyclic sultam library utilizing a Heck-aza-Michael strategy.

Zang Q, Javed S, Porubsky P, Ullah F, Neuenswander B, Lushington GH, Basha FZ, Organ MG, Hanson PR.

ACS Comb Sci. 2012 Mar 12;14(3):211-7. doi: 10.1021/co200181x. Epub 2012 Feb 6.


Solid-phase synthesis and chemical space analysis of a 190-membered alkaloid/terpenoid-like library.

Moura-Letts G, Diblasi CM, Bauer RA, Tan DS.

Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6745-50. doi: 10.1073/pnas.1015268108. Epub 2011 Mar 30.


Diversity-oriented synthesis of macrocyclic peptidomimetics.

Isidro-Llobet A, Murillo T, Bello P, Cilibrizzi A, Hodgkinson JT, Galloway WR, Bender A, Welch M, Spring DR.

Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6793-8. doi: 10.1073/pnas.1015267108. Epub 2011 Mar 7.

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