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DNA Polymerase θ: A Unique Multifunctional End-Joining Machine.

Black SJ, Kashkina E, Kent T, Pomerantz RT.

Genes (Basel). 2016 Sep 21;7(9). pii: E67. doi: 10.3390/genes7090067. Review.


DNA polymerase θ specializes in incorporating synthetic expanded-size (xDNA) nucleotides.

Kent T, Rusanov TD, Hoang TM, Velema WA, Krueger AT, Copeland WC, Kool ET, Pomerantz RT.

Nucleic Acids Res. 2016 Nov 2;44(19):9381-9392.


DNA polymerase θ (POLQ), double-strand break repair, and cancer.

Wood RD, Doublié S.

DNA Repair (Amst). 2016 Aug;44:22-32. doi: 10.1016/j.dnarep.2016.05.003. Review.


Improving the Predictive Value of Preclinical Studies in Support of Radiotherapy Clinical Trials.

Coleman CN, Higgins GS, Brown JM, Baumann M, Kirsch DG, Willers H, Prasanna PG, Dewhirst MW, Bernhard EJ, Ahmed MM.

Clin Cancer Res. 2016 Jul 1;22(13):3138-47. doi: 10.1158/1078-0432.CCR-16-0069. Review.


A synthetic lethal screen identifies ATR-inhibition as a novel therapeutic approach for POLD1-deficient cancers.

Hocke S, Guo Y, Job A, Orth M, Ziesch A, Lauber K, De Toni EN, Gress TM, Herbst A, Göke B, Gallmeier E.

Oncotarget. 2016 Feb 9;7(6):7080-95. doi: 10.18632/oncotarget.6857.


Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway.

Newman JA, Cooper CD, Aitkenhead H, Gileadi O.

Structure. 2015 Dec 1;23(12):2319-30. doi: 10.1016/j.str.2015.10.014.


Linking DNA polymerase theta structure and function in health and disease.

Beagan K, McVey M.

Cell Mol Life Sci. 2016 Feb;73(3):603-15. doi: 10.1007/s00018-015-2078-9.


Polymerase Θ is a key driver of genome evolution and of CRISPR/Cas9-mediated mutagenesis.

van Schendel R, Roerink SF, Portegijs V, van den Heuvel S, Tijsterman M.

Nat Commun. 2015 Jun 16;6:7394. doi: 10.1038/ncomms8394.


Reptin regulates DNA double strand breaks repair in human hepatocellular carcinoma.

Raymond AA, Benhamouche S, Neaud V, Di Martino J, Javary J, Rosenbaum J.

PLoS One. 2015 Apr 15;10(4):e0123333. doi: 10.1371/journal.pone.0123333.


Functional genomics screening utilizing mutant mouse embryonic stem cells identifies novel radiation-response genes.

Loesch K, Galaviz S, Hamoui Z, Clanton R, Akabani G, Deveau M, DeJesus M, Ioerger T, Sacchettini JC, Wallis D.

PLoS One. 2015 Apr 8;10(4):e0120534. doi: 10.1371/journal.pone.0120534.


Identification of vitamin B1 metabolism as a tumor-specific radiosensitizing pathway using a high-throughput colony formation screen.

Tiwana GS, Prevo R, Buffa FM, Yu S, Ebner DV, Howarth A, Folkes LK, Budwal B, Chu KY, Durrant L, Muschel RJ, McKenna WG, Higgins GS.

Oncotarget. 2015 Mar 20;6(8):5978-89.


Human DNA polymerase θ grasps the primer terminus to mediate DNA repair.

Zahn KE, Averill AM, Aller P, Wood RD, Doublié S.

Nat Struct Mol Biol. 2015 Apr;22(4):304-11. doi: 10.1038/nsmb.2993.


Screening analysis of ubiquitin ligases reveals G2E3 as a potential target for chemosensitizing cancer cells.

Schmidt F, Kunze M, Loock AC, Dobbelstein M.

Oncotarget. 2015 Jan 20;6(2):617-32.


Abundance of the Fanconi anaemia core complex is regulated by the RuvBL1 and RuvBL2 AAA+ ATPases.

Rajendra E, Garaycoechea JI, Patel KJ, Passmore LA.

Nucleic Acids Res. 2014 Dec 16;42(22):13736-48. doi: 10.1093/nar/gku1230.


A DNA repair variant in POLQ (c.-1060A > G) is associated to hereditary breast cancer patients: a case-control study.

Brandalize AP, Schüler-Faccini L, Hoffmann JS, Caleffi M, Cazaux C, Ashton-Prolla P.

BMC Cancer. 2014 Nov 19;14:850. doi: 10.1186/1471-2407-14-850.


Mechanism of suppression of chromosomal instability by DNA polymerase POLQ.

Yousefzadeh MJ, Wyatt DW, Takata K, Mu Y, Hensley SC, Tomida J, Bylund GO, Doublié S, Johansson E, Ramsden DA, McBride KM, Wood RD.

PLoS Genet. 2014 Oct 2;10(10):e1004654. doi: 10.1371/journal.pgen.1004654.


Characterization of DNA repair deficient strains of Chlamydomonas reinhardtii generated by insertional mutagenesis.

Plecenikova A, Slaninova M, Riha K.

PLoS One. 2014 Aug 21;9(8):e105482. doi: 10.1371/journal.pone.0105482.


Having a direct look: analysis of DNA damage and repair mechanisms by next generation sequencing.

Meier B, Gartner A.

Exp Cell Res. 2014 Nov 15;329(1):35-41. doi: 10.1016/j.yexcr.2014.08.011. Review.


Molecular radiobiology: the state of the art.

Giaccia AJ.

J Clin Oncol. 2014 Sep 10;32(26):2871-8. doi: 10.1200/JCO.2014.57.2776. Review.


A high content clonogenic survival drug screen identifies mek inhibitors as potent radiation sensitizers for KRAS mutant non-small-cell lung cancer.

Lin SH, Zhang J, Giri U, Stephan C, Sobieski M, Zhong L, Mason KA, Molkentine J, Thames HD, Yoo SS, Heymach JV.

J Thorac Oncol. 2014 Jul;9(7):965-73. doi: 10.1097/JTO.0000000000000199.

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