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Items: 16

1.

Nuclear receptors: emerging drug targets for parasitic diseases.

Wang Z, Schaffer NE, Kliewer SA, Mangelsdorf DJ.

J Clin Invest. 2017 Apr 3;127(4):1165-1171. doi: 10.1172/JCI88890. Epub 2017 Feb 6.

2.

Stage-Specific Transcriptome and Proteome Analyses of the Filarial Parasite Onchocerca volvulus and Its Wolbachia Endosymbiont.

Bennuru S, Cotton JA, Ribeiro JM, Grote A, Harsha B, Holroyd N, Mhashilkar A, Molina DM, Randall AZ, Shandling AD, Unnasch TR, Ghedin E, Berriman M, Lustigman S, Nutman TB.

MBio. 2016 Nov 23;7(6). pii: e02028-16. doi: 10.1128/mBio.02028-16.

3.

The genome of Onchocerca volvulus, agent of river blindness.

Cotton JA, Bennuru S, Grote A, Harsha B, Tracey A, Beech R, Doyle SR, Dunn M, Hotopp JC, Holroyd N, Kikuchi T, Lambert O, Mhashilkar A, Mutowo P, Nursimulu N, Ribeiro JM, Rogers MB, Stanley E, Swapna LS, Tsai IJ, Unnasch TR, Voronin D, Parkinson J, Nutman TB, Ghedin E, Berriman M, Lustigman S.

Nat Microbiol. 2016 Nov 21;2:16216. doi: 10.1038/nmicrobiol.2016.216.

4.

Identification of Ecdysone Hormone Receptor Agonists as a Therapeutic Approach for Treating Filarial Infections.

Mhashilkar AS, Vankayala SL, Liu C, Kearns F, Mehrotra P, Tzertzinis G, Palli SR, Woodcock HL, Unnasch TR.

PLoS Negl Trop Dis. 2016 Jun 14;10(6):e0004772. doi: 10.1371/journal.pntd.0004772. eCollection 2016 Jun.

5.

Phenotypic and molecular analysis of the effect of 20-hydroxyecdysone on the human filarial parasite Brugia malayi.

Mhashilkar AS, Adapa SR, Jiang RH, Williams SA, Zaky W, Slatko BE, Luck AN, Moorhead AR, Unnasch TR.

Int J Parasitol. 2016 May;46(5-6):333-41. doi: 10.1016/j.ijpara.2016.01.005. Epub 2016 Feb 16.

6.

Rendering the Intractable More Tractable: Tools from Caenorhabditis elegans Ripe for Import into Parasitic Nematodes.

Ward JD.

Genetics. 2015 Dec;201(4):1279-94. doi: 10.1534/genetics.115.182717. Review.

7.

Enzymology of the nematode cuticle: A potential drug target?

Page AP, Stepek G, Winter AD, Pertab D.

Int J Parasitol Drugs Drug Resist. 2014 Jun 6;4(2):133-41. doi: 10.1016/j.ijpddr.2014.05.003. eCollection 2014 Aug. Review.

8.

Genome-wide tissue-specific gene expression, co-expression and regulation of co-expressed genes in adult nematode Ascaris suum.

Rosa BA, Jasmer DP, Mitreva M.

PLoS Negl Trop Dis. 2014 Feb 6;8(2):e2678. doi: 10.1371/journal.pntd.0002678. eCollection 2014 Feb.

9.

Identification of genes containing ecdysone response elements in the genome of Brugia malayi.

Liu C, Enright T, Tzertzinis G, Unnasch TR.

Mol Biochem Parasitol. 2012 Nov;186(1):38-43. doi: 10.1016/j.molbiopara.2012.09.005. Epub 2012 Sep 24.

10.

Improvement of pest resistance in transgenic tobacco plants expressing dsRNA of an insect-associated gene EcR.

Zhu JQ, Liu S, Ma Y, Zhang JQ, Qi HS, Wei ZJ, Yao Q, Zhang WQ, Li S.

PLoS One. 2012;7(6):e38572. doi: 10.1371/journal.pone.0038572. Epub 2012 Jun 7.

11.

Regulation of the C. elegans molt by pqn-47.

Russel S, Frand AR, Ruvkun G.

Dev Biol. 2011 Dec 15;360(2):297-309. doi: 10.1016/j.ydbio.2011.09.025. Epub 2011 Oct 1.

12.

Analysis of transcriptional regulation of tetracycline responsive genes in Brugia malayi.

Liu C, Kelen PV, Ghedin E, Lustigman S, Unnasch TR.

Mol Biochem Parasitol. 2011 Dec;180(2):106-11. doi: 10.1016/j.molbiopara.2011.09.004. Epub 2011 Sep 16.

13.

Nucleic acid transfection and transgenesis in parasitic nematodes.

Lok JB.

Parasitology. 2012 Apr;139(5):574-88. doi: 10.1017/S0031182011001387. Epub 2011 Aug 31. Review.

14.

In vivo transfection of developmentally competent Brugia malayi infective larvae.

Xu S, Liu C, Tzertzinis G, Ghedin E, Evans CC, Kaplan R, Unnasch TR.

Int J Parasitol. 2011 Mar;41(3-4):355-62. doi: 10.1016/j.ijpara.2010.10.005. Epub 2010 Nov 28.

15.

Nuclear hormone receptors in parasitic helminths.

Wu W, LoVerde PT.

Mol Cell Endocrinol. 2011 Mar 1;334(1-2):56-66. doi: 10.1016/j.mce.2010.06.011. Epub 2010 Jun 26. Review.

16.

Nuclear hormone receptors in nematodes: evolution and function.

Taubert S, Ward JD, Yamamoto KR.

Mol Cell Endocrinol. 2011 Mar 1;334(1-2):49-55. doi: 10.1016/j.mce.2010.04.021. Epub 2010 May 10. Review.

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