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Variability in Usual Care Mechanical Ventilation for Pediatric Acute Respiratory Distress Syndrome: Time for a Decision Support Protocol?

Newth CJL, Sward KA, Khemani RG, Page K, Meert KL, Carcillo JA, Shanley TP, Moler FW, Pollack MM, Dalton HJ, Wessel DL, Berger JT, Berg RA, Harrison RE, Holubkov R, Doctor A, Dean JM, Jenkins TL, Nicholson CE; Eunice Kennedy Shriver National Institute for Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN).

Pediatr Crit Care Med. 2017 Nov;18(11):e521-e529. doi: 10.1097/PCC.0000000000001319.


Simvastatin for patients with acute respiratory distress syndrome: long-term outcomes and cost-effectiveness from a randomised controlled trial.

Agus A, Hulme C, Verghis RM, McDowell C, Jackson C, O'Kane CM, Laffey JG, McAuley DF.

Crit Care. 2017 May 17;21(1):108. doi: 10.1186/s13054-017-1695-0.


Core Domains for Clinical Research in Acute Respiratory Failure Survivors: An International Modified Delphi Consensus Study.

Turnbull AE, Sepulveda KA, Dinglas VD, Chessare CM, Bingham CO 3rd, Needham DM.

Crit Care Med. 2017 Jun;45(6):1001-1010. doi: 10.1097/CCM.0000000000002435.


Lung-Protective Ventilation Initiated in the Emergency Department (LOV-ED): A Quasi-Experimental, Before-After Trial.

Fuller BM, Ferguson IT, Mohr NM, Drewry AM, Palmer C, Wessman BT, Ablordeppey E, Keeperman J, Stephens RJ, Briscoe CC, Kolomiets AA, Hotchkiss RS, Kollef MH.

Ann Emerg Med. 2017 Sep;70(3):406-418.e4. doi: 10.1016/j.annemergmed.2017.01.013. Epub 2017 Mar 2.


Randomized Clinical Trial of a Combination of an Inhaled Corticosteroid and Beta Agonist in Patients at Risk of Developing the Acute Respiratory Distress Syndrome.

Festic E, Carr GE, Cartin-Ceba R, Hinds RF, Banner-Goodspeed V, Bansal V, Asuni AT, Talmor D, Rajagopalan G, Frank RD, Gajic O, Matthay MA, Levitt JE.

Crit Care Med. 2017 May;45(5):798-805. doi: 10.1097/CCM.0000000000002284.


Blood product transfusion in emergency department patients: a case-control study of practice patterns and impact on outcome.

Beyer A, Rees R, Palmer C, Wessman BT, Fuller BM.

Int J Emerg Med. 2017 Dec;10(1):5. doi: 10.1186/s12245-017-0133-z. Epub 2017 Feb 2.


A systematic review finds limited data on measurement properties of instruments measuring outcomes in adult intensive care unit survivors.

Robinson KA, Davis WE, Dinglas VD, Mendez-Tellez PA, Rabiee A, Sukrithan V, Yalamanchilli R, Turnbull AE, Needham DM.

J Clin Epidemiol. 2017 Feb;82:37-46. doi: 10.1016/j.jclinepi.2016.08.014. Epub 2016 Nov 16. Review.


Lung Injury Prediction Score in Hospitalized Patients at Risk of Acute Respiratory Distress Syndrome.

Soto GJ, Kor DJ, Park PK, Hou PC, Kaufman DA, Kim M, Yadav H, Teman N, Hsu MC, Shvilkina T, Grewal Y, De Aguirre M, Gunda S, Gajic O, Gong MN.

Crit Care Med. 2016 Dec;44(12):2182-2191.


Intensivist-reported Facilitators and Barriers to Discussing Post-Discharge Outcomes with Intensive Care Unit Surrogates. A Qualitative Study.

Turnbull AE, Davis WE, Needham DM, White DB, Eakin MN.

Ann Am Thorac Soc. 2016 Sep;13(9):1546-52. doi: 10.1513/AnnalsATS.201603-212OC.


Effect of Aspirin on Development of ARDS in At-Risk Patients Presenting to the Emergency Department: The LIPS-A Randomized Clinical Trial.

Kor DJ, Carter RE, Park PK, Festic E, Banner-Goodspeed VM, Hinds R, Talmor D, Gajic O, Ware LB, Gong MN; US Critical Illness and Injury Trials Group: Lung Injury Prevention with Aspirin Study Group (USCIITG: LIPS-A).

JAMA. 2016 Jun 14;315(22):2406-14. doi: 10.1001/jama.2016.6330. Erratum in: JAMA. 2016 Sep 13;316(10):1116.


The SF-36 Offers a Strong Measure of Mental Health Symptoms in Survivors of Acute Respiratory Failure. A Tri-National Analysis.

Pfoh ER, Chan KS, Dinglas VD, Cuthbertson BH, Elliott D, Porter R, Bienvenu OJ, Hopkins RO, Needham DM.

Ann Am Thorac Soc. 2016 Aug;13(8):1343-50. doi: 10.1513/AnnalsATS.201510-705OC.


A Novel Picture Guide to Improve Spiritual Care and Reduce Anxiety in Mechanically Ventilated Adults in the Intensive Care Unit.

Berning JN, Poor AD, Buckley SM, Patel KR, Lederer DJ, Goldstein NE, Brodie D, Baldwin MR.

Ann Am Thorac Soc. 2016 Aug;13(8):1333-42. doi: 10.1513/AnnalsATS.201512-831OC.


Outcome Measurement in ICU Survivorship Research From 1970 to 2013: A Scoping Review of 425 Publications.

Turnbull AE, Rabiee A, Davis WE, Nasser MF, Venna VR, Lolitha R, Hopkins RO, Bienvenu OJ, Robinson KA, Needham DM.

Crit Care Med. 2016 Jul;44(7):1267-77. doi: 10.1097/CCM.0000000000001651. Review.


Failure to Improve the Oxygenation Index Is a Useful Predictor of Therapy Failure in Acute Respiratory Distress Syndrome Clinical Trials.

Go L, Budinger GR, Kwasny MJ, Peng J, Forel JM, Papazian L, Jain M.

Crit Care Med. 2016 Jan;44(1):e40-4. doi: 10.1097/CCM.0000000000001295.


Sepsis-associated pulmonary complications in emergency department patients monitored with serial lactate: An observational cohort study.

Dettmer MR, Mohr NM, Fuller BM.

J Crit Care. 2015 Dec;30(6):1163-8. doi: 10.1016/j.jcrc.2015.07.031. Epub 2015 Aug 1.


Nicotinamide exacerbates hypoxemia in ventilator-induced lung injury independent of neutrophil infiltration.

Jones HD, Yoo J, Crother TR, Kyme P, Ben-Shlomo A, Khalafi R, Tseng CW, Parks WC, Arditi M, Liu GY, Shimada K.

PLoS One. 2015 Apr 13;10(4):e0123460. doi: 10.1371/journal.pone.0123460. eCollection 2015. Erratum in: PLoS One. 2015;10(5):e0128735.


NF-κB inhibitors impair lung epithelial tight junctions in the absence of inflammation.

Ward C, Schlingmann B, Stecenko AA, Guidot DM, Koval M.

Tissue Barriers. 2015 Apr 3;3(1-2):e982424. doi: 10.4161/21688370.2014.982424. eCollection 2015.


Mechanical Ventilation and ARDS in the ED: A Multicenter, Observational, Prospective, Cross-sectional Study.

Fuller BM, Mohr NM, Miller CN, Deitchman AR, Levine BJ, Castagno N, Hassebroek EC, Dhedhi A, Scott-Wittenborn N, Grace E, Lehew C, Kollef MH.

Chest. 2015 Aug;148(2):365-374. doi: 10.1378/chest.14-2476.


Estimating dead-space fraction for secondary analyses of acute respiratory distress syndrome clinical trials.

Beitler JR, Thompson BT, Matthay MA, Talmor D, Liu KD, Zhuo H, Hayden D, Spragg RG, Malhotra A.

Crit Care Med. 2015 May;43(5):1026-35. doi: 10.1097/CCM.0000000000000921.

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