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Items: 1 to 20 of 60

1.

Mechanisms of Lipid Scrambling by the G Protein-Coupled Receptor Opsin.

Morra G, Razavi AM, Pandey K, Weinstein H, Menon AK, Khelashvili G.

Structure. 2018 Feb 6;26(2):356-367.e3. doi: 10.1016/j.str.2017.11.020. Epub 2017 Dec 28.

PMID:
29290486
2.

Selective Cannabinoid 2 Receptor Stimulation Reduces Tubular Epithelial Cell Damage after Renal Ischemia-Reperfusion Injury.

Pressly JD, Mustafa SM, Adibi AH, Alghamdi S, Pandey P, Roy KK, Doerksen RJ, Moore BM Jr., Park F.

J Pharmacol Exp Ther. 2018 Feb;364(2):287-299. doi: 10.1124/jpet.117.245522. Epub 2017 Nov 29.

PMID:
29187590
3.

CB1 Receptor Signaling in the Brain: Extracting Specificity from Ubiquity.

Busquets-Garcia A, Bains J, Marsicano G.

Neuropsychopharmacology. 2018 Jan;43(1):4-20. doi: 10.1038/npp.2017.206. Epub 2017 Sep 1.

4.

Molecular Dynamics Methodologies for Probing Cannabinoid Ligand/Receptor Interaction.

Lynch DL, Hurst DP, Shore DM, Pitman MC, Reggio PH.

Methods Enzymol. 2017;593:449-490. doi: 10.1016/bs.mie.2017.05.004. Epub 2017 Jul 4.

5.

Methods for the Development of In Silico GPCR Models.

Morales P, Hurst DP, Reggio PH.

Methods Enzymol. 2017;593:405-448. doi: 10.1016/bs.mie.2017.05.005. Epub 2017 Jul 14.

6.

Activation mechanisms of the first sphingosine-1-phosphate receptor.

Caliman AD, Miao Y, McCammon JA.

Protein Sci. 2017 Jun;26(6):1150-1160. doi: 10.1002/pro.3165. Epub 2017 Apr 12.

PMID:
28370663
7.

The Ratio of 2-AG to Its Isomer 1-AG as an Intrinsic Fine Tuning Mechanism of CB1 Receptor Activation.

Dócs K, Mészár Z, Gonda S, Kiss-Szikszai A, Holló K, Antal M, Hegyi Z.

Front Cell Neurosci. 2017 Feb 20;11:39. doi: 10.3389/fncel.2017.00039. eCollection 2017.

8.

Membrane cholesterol access into a G-protein-coupled receptor.

Guixà-González R, Albasanz JL, Rodriguez-Espigares I, Pastor M, Sanz F, Martí-Solano M, Manna M, Martinez-Seara H, Hildebrand PW, Martín M, Selent J.

Nat Commun. 2017 Feb 21;8:14505. doi: 10.1038/ncomms14505.

9.

Molecular Targets of the Phytocannabinoids: A Complex Picture.

Morales P, Hurst DP, Reggio PH.

Prog Chem Org Nat Prod. 2017;103:103-131. doi: 10.1007/978-3-319-45541-9_4. Review.

10.

Functional selectivity at G-protein coupled receptors: Advancing cannabinoid receptors as drug targets.

Mallipeddi S, Janero DR, Zvonok N, Makriyannis A.

Biochem Pharmacol. 2017 Mar 15;128:1-11. doi: 10.1016/j.bcp.2016.11.014. Epub 2016 Nov 24. Review.

PMID:
27890725
11.

Allosteric Modulation: An Alternate Approach Targeting the Cannabinoid CB1 Receptor.

Nguyen T, Li JX, Thomas BF, Wiley JL, Kenakin TP, Zhang Y.

Med Res Rev. 2017 May;37(3):441-474. doi: 10.1002/med.21418. Epub 2016 Nov 23. Review.

PMID:
27879006
12.

High-resolution crystal structure of the human CB1 cannabinoid receptor.

Shao Z, Yin J, Chapman K, Grzemska M, Clark L, Wang J, Rosenbaum DM.

Nature. 2016 Nov 16. doi: 10.1038/nature20613. [Epub ahead of print]

13.

Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders.

Navarro G, Morales P, Rodríguez-Cueto C, Fernández-Ruiz J, Jagerovic N, Franco R.

Front Neurosci. 2016 Sep 13;10:406. doi: 10.3389/fnins.2016.00406. eCollection 2016. Review.

14.

Chromenopyrazole, a Versatile Cannabinoid Scaffold with in Vivo Activity in a Model of Multiple Sclerosis.

Morales P, Gómez-Cañas M, Navarro G, Hurst DP, Carrillo-Salinas FJ, Lagartera L, Pazos R, Goya P, Reggio PH, Guaza C, Franco R, Fernández-Ruiz J, Jagerovic N.

J Med Chem. 2016 Jul 28;59(14):6753-6771. doi: 10.1021/acs.jmedchem.6b00397. Epub 2016 Jul 6.

15.

Difference and Influence of Inactive and Active States of Cannabinoid Receptor Subtype CB2: From Conformation to Drug Discovery.

Hu J, Feng Z, Ma S, Zhang Y, Tong Q, Alqarni MH, Gou X, Xie XQ.

J Chem Inf Model. 2016 Jun 27;56(6):1152-63. doi: 10.1021/acs.jcim.5b00739. Epub 2016 May 26.

16.

Adaptive Multilevel Splitting Method for Molecular Dynamics Calculation of Benzamidine-Trypsin Dissociation Time.

Teo I, Mayne CG, Schulten K, Lelièvre T.

J Chem Theory Comput. 2016 Jun 14;12(6):2983-9. doi: 10.1021/acs.jctc.6b00277. Epub 2016 May 18.

17.

Cell membranes… and how long drugs may exert beneficial pharmacological activity in vivo.

Vauquelin G.

Br J Clin Pharmacol. 2016 Sep;82(3):673-82. doi: 10.1111/bcp.12996. Epub 2016 May 29. Review.

18.

Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe.

Laprairie RB, Kulkarni AR, Kulkarni PM, Hurst DP, Lynch D, Reggio PH, Janero DR, Pertwee RG, Stevenson LA, Kelly ME, Denovan-Wright EM, Thakur GA.

ACS Chem Neurosci. 2016 Jun 15;7(6):776-98. doi: 10.1021/acschemneuro.6b00041. Epub 2016 Apr 25.

19.

Lipid interaction sites on channels, transporters and receptors: Recent insights from molecular dynamics simulations.

Hedger G, Sansom MSP.

Biochim Biophys Acta. 2016 Oct;1858(10):2390-2400. doi: 10.1016/j.bbamem.2016.02.037. Epub 2016 Mar 3. Review.

20.

The pathway of ligand entry from the membrane bilayer to a lipid G protein-coupled receptor.

Stanley N, Pardo L, Fabritiis GD.

Sci Rep. 2016 Mar 4;6:22639. doi: 10.1038/srep22639.

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