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TGFβ1-induced SMAD2/3 and SMAD1/5 phosphorylation are both ALK5-kinase-dependent in primary chondrocytes and mediated by TAK1 kinase activity.

van Caam A, Madej W, Garcia de Vinuesa A, Goumans MJ, Ten Dijke P, Blaney Davidson E, van der Kraan P.

Arthritis Res Ther. 2017 May 31;19(1):112. doi: 10.1186/s13075-017-1302-4.


TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease.

Wu M, Chen G, Li YP.

Bone Res. 2016 Apr 26;4:16009. doi: 10.1038/boneres.2016.9. eCollection 2016. Review.


Heterozygous Mutations in MAP3K7, Encoding TGF-β-Activated Kinase 1, Cause Cardiospondylocarpofacial Syndrome.

Le Goff C, Rogers C, Le Goff W, Pinto G, Bonnet D, Chrabieh M, Alibeu O, Nistchke P, Munnich A, Picard C, Cormier-Daire V.

Am J Hum Genet. 2016 Aug 4;99(2):407-13. doi: 10.1016/j.ajhg.2016.06.005. Epub 2016 Jul 14.


Signaling pathways regulating cartilage growth plate formation and activity.

Samsa WE, Zhou X, Zhou G.

Semin Cell Dev Biol. 2017 Feb;62:3-15. doi: 10.1016/j.semcdb.2016.07.008. Epub 2016 Jul 11. Review.


Notch signaling indirectly promotes chondrocyte hypertrophy via regulation of BMP signaling and cell cycle arrest.

Shang X, Wang J, Luo Z, Wang Y, Morandi MM, Marymont JV, Hilton MJ, Dong Y.

Sci Rep. 2016 May 5;6:25594. doi: 10.1038/srep25594.


Role of NOD2 Pathway Genes in Sarcoidosis Cases with Clinical Characteristics of Blau Syndrome.

Bello GA, Adrianto I, Dumancas GG, Levin AM, Iannuzzi MC, Rybicki BA, Montgomery C.

Am J Respir Crit Care Med. 2015 Nov 1;192(9):1133-5. doi: 10.1164/rccm.201507-1344LE. No abstract available.


Focus on the p38 MAPK signaling pathway in bone development and maintenance.

Thouverey C, Caverzasio J.

Bonekey Rep. 2015 Jun 10;4:711. doi: 10.1038/bonekey.2015.80. eCollection 2015. Review.


Cartilage regeneration for treatment of osteoarthritis: a paradigm for nonsurgical intervention.

Tiku ML, Sabaawy HE.

Ther Adv Musculoskelet Dis. 2015 Jun;7(3):76-87. doi: 10.1177/1759720X15576866. Review.


Precise spatial restriction of BMP signaling is essential for articular cartilage differentiation.

Ray A, Singh PN, Sohaskey ML, Harland RM, Bandyopadhyay A.

Development. 2015 Mar 15;142(6):1169-79. doi: 10.1242/dev.110940.


Ablation of Tak1 in osteoclast progenitor leads to defects in skeletal growth and bone remodeling in mice.

Qi B, Cong Q, Li P, Ma G, Guo X, Yeh J, Xie M, Schneider MD, Liu H, Li B.

Sci Rep. 2014 Nov 24;4:7158. doi: 10.1038/srep07158.


A review of crosstalk between MAPK and Wnt signals and its impact on cartilage regeneration.

Zhang Y, Pizzute T, Pei M.

Cell Tissue Res. 2014 Dec;358(3):633-49. doi: 10.1007/s00441-014-2010-x. Epub 2014 Oct 14. Review.


Genesis and morphogenesis of limb synovial joints and articular cartilage.

Decker RS, Koyama E, Pacifici M.

Matrix Biol. 2014 Oct;39:5-10. doi: 10.1016/j.matbio.2014.08.006. Epub 2014 Aug 27. Review.


TGFβ signaling in cartilage development and maintenance.

Wang W, Rigueur D, Lyons KM.

Birth Defects Res C Embryo Today. 2014 Mar;102(1):37-51. doi: 10.1002/bdrc.21058. Review.


Inhibition of TAK1 and/or JAK can rescue impaired chondrogenic differentiation of human mesenchymal stem cells in osteoarthritis-like conditions.

van Beuningen HM, de Vries-van Melle ML, Vitters EL, Schreurs W, van den Berg WB, van Osch GJ, van der Kraan PM.

Tissue Eng Part A. 2014 Aug;20(15-16):2243-52. doi: 10.1089/ten.TEA.2013.0553. Epub 2014 Mar 25.


BMP-2 induces ATF4 phosphorylation in chondrocytes through a COX-2/PGE2 dependent signaling pathway.

Li TF, Yukata K, Yin G, Sheu T, Maruyama T, Jonason JH, Hsu W, Zhang X, Xiao G, Konttinen YT, Chen D, O'Keefe RJ.

Osteoarthritis Cartilage. 2014 Mar;22(3):481-9. doi: 10.1016/j.joca.2013.12.020. Epub 2014 Jan 11.


Bone morphogenetic proteins signal via SMAD and mitogen-activated protein (MAP) kinase pathways at distinct times during osteoclastogenesis.

Broege A, Pham L, Jensen ED, Emery A, Huang TH, Stemig M, Beppu H, Petryk A, O'Connor M, Mansky K, Gopalakrishnan R.

J Biol Chem. 2013 Dec 27;288(52):37230-40. doi: 10.1074/jbc.M113.496950. Epub 2013 Nov 14.


TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages.

Gao L, Sheu TJ, Dong Y, Hoak DM, Zuscik MJ, Schwarz EM, Hilton MJ, O'Keefe RJ, Jonason JH.

J Cell Sci. 2013 Dec 15;126(Pt 24):5704-13. doi: 10.1242/jcs.135483. Epub 2013 Oct 21.


Expression and functional study of extracellular BMP antagonists during the morphogenesis of the digits and their associated connective tissues.

Lorda-Diez CI, Montero JA, Rodriguez-Leon J, Garcia-Porrero JA, Hurle JM.

PLoS One. 2013;8(4):e60423. doi: 10.1371/journal.pone.0060423. Epub 2013 Apr 3.


Deletion of TAK1 in the myeloid lineage results in the spontaneous development of myelomonocytic leukemia in mice.

Lamothe B, Lai Y, Hur L, Orozco NM, Wang J, Campos AD, Xie M, Schneider MD, Lockworth CR, Jakacky J, Tran D, Ho M, Dawud S, Dong C, Lin HK, Hu P, Estrov Z, Bueso-Ramos CE, Darnay BG.

PLoS One. 2012;7(12):e51228. doi: 10.1371/journal.pone.0051228. Epub 2012 Dec 10.


ECM stiffness primes the TGFβ pathway to promote chondrocyte differentiation.

Allen JL, Cooke ME, Alliston T.

Mol Biol Cell. 2012 Sep;23(18):3731-42. Epub 2012 Jul 25.

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