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Molecular Pathways: Receptor Ectodomain Shedding in Treatment, Resistance, and Monitoring of Cancer.

Miller MA, Sullivan RJ, Lauffenburger DA.

Clin Cancer Res. 2017 Feb 1;23(3):623-629. doi: 10.1158/1078-0432.CCR-16-0869.


Growth factor and co-receptor release by structural regulation of substrate metalloprotease accessibility.

Parra LM, Hartmann M, Schubach S, Ma J, Herrlich P, Herrlich A.

Sci Rep. 2016 Nov 23;6:37464. doi: 10.1038/srep37464.


A Disintegrin and Metalloprotease 17 in the Cardiovascular and Central Nervous Systems.

Xu J, Mukerjee S, Silva-Alves CR, Carvalho-Galvão A, Cruz JC, Balarini CM, Braga VA, Lazartigues E, França-Silva MS.

Front Physiol. 2016 Oct 18;7:469. Review.


Control of ADAM17 activity by regulation of its cellular localisation.

Lorenzen I, Lokau J, Korpys Y, Oldefest M, Flynn CM, Künzel U, Garbers C, Freeman M, Grötzinger J, Düsterhöft S.

Sci Rep. 2016 Oct 12;6:35067. doi: 10.1038/srep35067. Erratum in: Sci Rep. 2016 Nov 21;6:37364.


PPM1A silences cytosolic RNA sensing and antiviral defense through direct dephosphorylation of MAVS and TBK1.

Xiang W, Zhang Q, Lin X, Wu S, Zhou Y, Meng F, Fan Y, Shen T, Xiao M, Xia Z, Zou J, Feng XH, Xu P.

Sci Adv. 2016 Jul 1;2(7):e1501889. doi: 10.1126/sciadv.1501889.


Mst1 shuts off cytosolic antiviral defense through IRF3 phosphorylation.

Meng F, Zhou R, Wu S, Zhang Q, Jin Q, Zhou Y, Plouffe SW, Liu S, Song H, Xia Z, Zhao B, Ye S, Feng XH, Guan KL, Zou J, Xu P.

Genes Dev. 2016 May 1;30(9):1086-100. doi: 10.1101/gad.277533.116.


The ADAMs family of proteases as targets for the treatment of cancer.

Mullooly M, McGowan PM, Crown J, Duffy MJ.

Cancer Biol Ther. 2016 Aug 2;17(8):870-80. doi: 10.1080/15384047.2016.1177684.


Role of the ACE2/Angiotensin 1-7 Axis of the Renin-Angiotensin System in Heart Failure.

Patel VB, Zhong JC, Grant MB, Oudit GY.

Circ Res. 2016 Apr 15;118(8):1313-26. doi: 10.1161/CIRCRESAHA.116.307708. Review.


Endogenous Transmembrane TNF-Alpha Protects Against Premature Senescence in Endothelial Colony Forming Cells.

Green LA, Njoku V, Mund J, Case J, Yoder M, Murphy MP, Clauss M.

Circ Res. 2016 May 13;118(10):1512-24. doi: 10.1161/CIRCRESAHA.116.308332.


TIMP3 Modulates GHR Abundance and GH Sensitivity.

Zhang Y, Wang X, Loesch K, May LA, Davis GE, Jiang J, Frank SJ.

Mol Endocrinol. 2016 Jun;30(6):587-99. doi: 10.1210/me.2015-1302.


Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance.

Miller MA, Oudin MJ, Sullivan RJ, Wang SJ, Meyer AS, Im H, Frederick DT, Tadros J, Griffith LG, Lee H, Weissleder R, Flaherty KT, Gertler FB, Lauffenburger DA.

Cancer Discov. 2016 Apr;6(4):382-99. doi: 10.1158/2159-8290.CD-15-0933.


Genomic characterization of esophageal squamous cell carcinoma: Insights from next-generation sequencing.

Sasaki Y, Tamura M, Koyama R, Nakagaki T, Adachi Y, Tokino T.

World J Gastroenterol. 2016 Feb 21;22(7):2284-93. doi: 10.3748/wjg.v22.i7.2284. Review.


Release of Matrix Metalloproteinases-2 and 9 by S-Nitrosylated Caveolin-1 Contributes to Degradation of Extracellular Matrix in tPA-Treated Hypoxic Endothelial Cells.

Song H, Cheng Y, Bi G, Zhu Y, Jun W, Ma W, Wu H.

PLoS One. 2016 Feb 16;11(2):e0149269. doi: 10.1371/journal.pone.0149269.


p38 MAPK-induced MDM2 degradation confers paclitaxel resistance through p53-mediated regulation of EGFR in human lung cancer cells.

Park SH, Seong MA, Lee HY.

Oncotarget. 2016 Feb 16;7(7):8184-99. doi: 10.18632/oncotarget.6945.


ADAM Proteases and Gastrointestinal Function.

Jones JC, Rustagi S, Dempsey PJ.

Annu Rev Physiol. 2016;78:243-76. doi: 10.1146/annurev-physiol-021014-071720. Review.


Serum amyloid A inhibits RANKL-induced osteoclast formation.

Oh E, Lee HY, Kim HJ, Park YJ, Seo JK, Park JS, Bae YS.

Exp Mol Med. 2015 Nov 13;47:e194. doi: 10.1038/emm.2015.83.


A systematic study of modulation of ADAM-mediated ectodomain shedding by site-specific O-glycosylation.

Goth CK, Halim A, Khetarpal SA, Rader DJ, Clausen H, Schjoldager KT.

Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):14623-8. doi: 10.1073/pnas.1511175112.


α-Lipoic acid reduces neurogenic hypertension by blunting oxidative stress-mediated increase in ADAM17.

de Queiroz TM, Xia H, Filipeanu CM, Braga VA, Lazartigues E.

Am J Physiol Heart Circ Physiol. 2015 Sep;309(5):H926-34. doi: 10.1152/ajpheart.00259.2015.


Distinct Intracellular Domain Substrate Modifications Selectively Regulate Ectodomain Cleavage of NRG1 or CD44.

Parra LM, Hartmann M, Schubach S, Li Y, Herrlich P, Herrlich A.

Mol Cell Biol. 2015 Oct;35(19):3381-95. doi: 10.1128/MCB.00500-15.

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