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Items: 1 to 20 of 28


Ubiquitin orchestrates proteasome dynamics between proliferation and quiescence in yeast.

Gu ZC, Wu E, Sailer C, Jando J, Styles E, Eisenkolb I, Kuschel M, Bitschar K, Wang X, Huang L, Vissa A, Yip CM, Yedidi RS, Friesen H, Enenkel C.

Mol Biol Cell. 2017 Sep 15;28(19):2479-2491. doi: 10.1091/mbc.E17-03-0162. Epub 2017 Aug 2.


Molecular Details Underlying Dynamic Structures and Regulation of the Human 26S Proteasome.

Wang X, Cimermancic P, Yu C, Schweitzer A, Chopra N, Engel JL, Greenberg C, Huszagh AS, Beck F, Sakata E, Yang Y, Novitsky EJ, Leitner A, Nanni P, Kahraman A, Guo X, Dixon JE, Rychnovsky SD, Aebersold R, Baumeister W, Sali A, Huang L.

Mol Cell Proteomics. 2017 May;16(5):840-854. doi: 10.1074/mcp.M116.065326. Epub 2017 Mar 14.


Characterization of Dynamic UbR-Proteasome Subcomplexes by In vivo Cross-linking (X) Assisted Bimolecular Tandem Affinity Purification (XBAP) and Label-free Quantitation.

Yu C, Yang Y, Wang X, Guan S, Fang L, Liu F, Walters KJ, Kaiser P, Huang L.

Mol Cell Proteomics. 2016 Jul;15(7):2279-92. doi: 10.1074/mcp.M116.058271. Epub 2016 Apr 25.


Ribosome-associated pentatricopeptide repeat proteins function as translational activators in mitochondria of trypanosomes.

Aphasizheva I, Maslov DA, Qian Y, Huang L, Wang Q, Costello CE, Aphasizhev R.

Mol Microbiol. 2016 Mar;99(6):1043-58. doi: 10.1111/mmi.13287. Epub 2016 Jan 20.


Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis.

Guo X, Wang X, Wang Z, Banerjee S, Yang J, Huang L, Dixon JE.

Nat Cell Biol. 2016 Feb;18(2):202-12. doi: 10.1038/ncb3289. Epub 2015 Dec 14.


Illuminating Spatial and Temporal Organization of Protein Interaction Networks by Mass Spectrometry-Based Proteomics.

Yang J, Wagner SA, Beli P.

Front Genet. 2015 Dec 1;6:344. doi: 10.3389/fgene.2015.00344. eCollection 2015. Review.


Activation of m1 muscarinic acetylcholine receptor induces surface transport of KCNQ channels through a CRMP-2-mediated pathway.

Jiang L, Kosenko A, Yu C, Huang L, Li X, Hoshi N.

J Cell Sci. 2015 Nov 15;128(22):4235-45. doi: 10.1242/jcs.175547. Epub 2015 Oct 7.


Ty3 Retrotransposon Hijacks Mating Yeast RNA Processing Bodies to Infect New Genomes.

Bilanchone V, Clemens K, Kaake R, Dawson AR, Matheos D, Nagashima K, Sitlani P, Patterson K, Chang I, Huang L, Sandmeyer S.

PLoS Genet. 2015 Sep 30;11(9):e1005528. doi: 10.1371/journal.pgen.1005528. eCollection 2015.


A new in vivo cross-linking mass spectrometry platform to define protein-protein interactions in living cells.

Kaake RM, Wang X, Burke A, Yu C, Kandur W, Yang Y, Novtisky EJ, Second T, Duan J, Kao A, Guan S, Vellucci D, Rychnovsky SD, Huang L.

Mol Cell Proteomics. 2014 Dec;13(12):3533-43. doi: 10.1074/mcp.M114.042630. Epub 2014 Sep 24.


RNA binding and core complexes constitute the U-insertion/deletion editosome.

Aphasizheva I, Zhang L, Wang X, Kaake RM, Huang L, Monti S, Aphasizhev R.

Mol Cell Biol. 2014 Dec 1;34(23):4329-42. doi: 10.1128/MCB.01075-14. Epub 2014 Sep 15.


Endogenous NO upon estradiol-17β stimulation and NO donor differentially regulate mitochondrial S-nitrosylation in endothelial cells.

Satohisa S, Zhang HH, Feng L, Yang YY, Huang L, Chen DB.

Endocrinology. 2014 Aug;155(8):3005-16. doi: 10.1210/en.2013-2174. Epub 2014 May 30.


Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates.

Besche HC, Sha Z, Kukushkin NV, Peth A, Hock EM, Kim W, Gygi S, Gutierrez JA, Liao H, Dick L, Goldberg AL.

EMBO J. 2014 May 16;33(10):1159-76. doi: 10.1002/embj.201386906. Epub 2014 May 8.


Characterizing the dynamics of proteasome complexes by proteomics approaches.

Kaake RM, Kao A, Yu C, Huang L.

Antioxid Redox Signal. 2014 Dec 10;21(17):2444-56. doi: 10.1089/ars.2013.5815. Epub 2014 Mar 27. Review.


Mmi1, the yeast homologue of mammalian TCTP, associates with stress granules in heat-shocked cells and modulates proteasome activity.

Rinnerthaler M, Lejskova R, Grousl T, Stradalova V, Heeren G, Richter K, Breitenbach-Koller L, Malinsky J, Hasek J, Breitenbach M.

PLoS One. 2013 Oct 28;8(10):e77791. doi: 10.1371/journal.pone.0077791. eCollection 2013.


Combining docking site and phosphosite predictions to find new substrates: identification of smoothelin-like-2 (SMTNL2) as a c-Jun N-terminal kinase (JNK) substrate.

Gordon EA, Whisenant TC, Zeller M, Kaake RM, Gordon WM, Krotee P, Patel V, Huang L, Baldi P, Bardwell L.

Cell Signal. 2013 Dec;25(12):2518-29. doi: 10.1016/j.cellsig.2013.08.004. Epub 2013 Aug 24.


The Upf factor complex interacts with aberrant products derived from mRNAs containing a premature termination codon and facilitates their proteasomal degradation.

Kuroha K, Ando K, Nakagawa R, Inada T.

J Biol Chem. 2013 Oct 4;288(40):28630-40. doi: 10.1074/jbc.M113.460691. Epub 2013 Aug 8.


Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation.

Sukhanova A, Gorin A, Serebriiskii IG, Gabitova L, Zheng H, Restifo D, Egleston BL, Cunningham D, Bagnyukova T, Liu H, Nikonova A, Adams GP, Zhou Y, Yang DH, Mehra R, Burtness B, Cai KQ, Klein-Szanto A, Kratz LE, Kelley RI, Weiner LM, Herman GE, Golemis EA, Astsaturov I.

Cancer Discov. 2013 Jan;3(1):96-111. doi: 10.1158/2159-8290.CD-12-0031. Epub 2012 Nov 2.


Mapping the structural topology of the yeast 19S proteasomal regulatory particle using chemical cross-linking and probabilistic modeling.

Kao A, Randall A, Yang Y, Patel VR, Kandur W, Guan S, Rychnovsky SD, Baldi P, Huang L.

Mol Cell Proteomics. 2012 Dec;11(12):1566-77. doi: 10.1074/mcp.M112.018374. Epub 2012 Apr 30.


Mapping the protein interaction network of the human COP9 signalosome complex using a label-free QTAX strategy.

Fang L, Kaake RM, Patel VR, Yang Y, Baldi P, Huang L.

Mol Cell Proteomics. 2012 May;11(5):138-47. doi: 10.1074/mcp.M111.016352. Epub 2012 Apr 3.

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