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LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs.

Hong S, Freeberg MA, Han T, Kamath A, Yao Y, Fukuda T, Suzuki T, Kim JK, Inoki K.

Elife. 2017 Jun 26;6. pii: e25237. doi: 10.7554/eLife.25237.


Reconstitution of a functional 7SK snRNP.

Brogie JE, Price DH.

Nucleic Acids Res. 2017 Apr 20. doi: 10.1093/nar/gkx262. [Epub ahead of print]


La-related protein 6 controls ciliated cell differentiation.

Manojlovic Z, Earwood R, Kato A, Perez D, Cabrera OA, Didier R, Megraw TL, Stefanovic B, Kato Y.

Cilia. 2017 Mar 23;6:4. doi: 10.1186/s13630-017-0047-7. eCollection 2017.


Applying a high-throughput fluorescence polarization assay for the discovery of chemical probes blocking La:RNA interactions in vitro and in cells.

Sommer G, Fedarovich A, Kota V, Rodriguez R, Smith CD, Heise T.

PLoS One. 2017 Mar 14;12(3):e0173246. doi: 10.1371/journal.pone.0173246. eCollection 2017.


Factors That Shape Eukaryotic tRNAomes:  Processing, Modification and Anticodon-Codon Use.

Maraia RJ, Arimbasseri AG.

Biomolecules. 2017 Mar 8;7(1). pii: E26. doi: 10.3390/biom7010026. Review.


La Deletion from Mouse Brain Alters Pre-tRNA Metabolism and Accumulation of Pre-5.8S rRNA, with Neuron Death and Reactive Astrocytosis.

Blewett NH, Iben JR, Gaidamakov S, Maraia RJ.

Mol Cell Biol. 2017 May 2;37(10). pii: e00588-16. doi: 10.1128/MCB.00588-16. Print 2017 May 15.


hLARP7 C-terminal domain contains an xRRM that binds the 3' hairpin of 7SK RNA.

Eichhorn CD, Chug R, Feigon J.

Nucleic Acids Res. 2016 Nov 16;44(20):9977-9989. Epub 2016 Sep 26.


The RNA-binding protein LARP4 regulates cancer cell migration and invasion.

Seetharaman S, Flemyng E, Shen J, Conte MR, Ridley AJ.

Cytoskeleton (Hoboken). 2016 Nov;73(11):680-690. doi: 10.1002/cm.21336. Epub 2016 Sep 26.


Cracking the control of RNA polymerase II elongation by 7SK snRNP and P-TEFb.

C Quaresma AJ, Bugai A, Barboric M.

Nucleic Acids Res. 2016 Sep 19;44(16):7527-39. doi: 10.1093/nar/gkw585. Epub 2016 Jul 1. Review.


SUMO-Modification of the La Protein Facilitates Binding to mRNA In Vitro and in Cells.

Kota V, Sommer G, Durette C, Thibault P, van Niekerk EA, Twiss JL, Heise T.

PLoS One. 2016 May 25;11(5):e0156365. doi: 10.1371/journal.pone.0156365. eCollection 2016.


Sumoylation in Synaptic Function and Dysfunction.

Schorova L, Martin S.

Front Synaptic Neurosci. 2016 Apr 28;8:9. doi: 10.3389/fnsyn.2016.00009. eCollection 2016. Review.


The La protein counteracts cisplatin-induced cell death by stimulating protein synthesis of anti-apoptotic factor Bcl2.

Heise T, Kota V, Brock A, Morris AB, Rodriguez RM, Zierk AW, Howe PH, Sommer G.

Oncotarget. 2016 May 17;7(20):29664-76. doi: 10.18632/oncotarget.8819.


Inhibition of PHLPP2/cyclin D1 protein translation contributes to the tumor suppressive effect of NFκB2 (p100).

Xu J, Wang Y, Hua X, Xu J, Tian Z, Jin H, Li J, Wu XR, Huang C.

Oncotarget. 2016 Jun 7;7(23):34112-30. doi: 10.18632/oncotarget.8746.


LARP6 Meets Collagen mRNA: Specific Regulation of Type I Collagen Expression.

Zhang Y, Stefanovic B.

Int J Mol Sci. 2016 Mar 22;17(3):419. doi: 10.3390/ijms17030419. Review.


An La-related protein controls cell cycle arrest by nuclear retrograde transport of tRNAs during diapause formation in Artemia.

Chen DF, Lin C, Wang HL, Zhang L, Dai L, Jia SN, Zhou R, Li R, Yang JS, Yang F, Clegg JS, Nagasawa H, Yang WJ.

BMC Biol. 2016 Mar 3;14:16. doi: 10.1186/s12915-016-0239-4.


Characterization of RyDEN (C19orf66) as an Interferon-Stimulated Cellular Inhibitor against Dengue Virus Replication.

Suzuki Y, Chin WX, Han Q, Ichiyama K, Lee CH, Eyo ZW, Ebina H, Takahashi H, Takahashi C, Tan BH, Hishiki T, Ohba K, Matsuyama T, Koyanagi Y, Tan YJ, Sawasaki T, Chu JJ, Vasudevan SG, Sano K, Yamamoto N.

PLoS Pathog. 2016 Jan 6;12(1):e1005357. doi: 10.1371/journal.ppat.1005357. eCollection 2016 Jan.


LARP4 Is Regulated by Tumor Necrosis Factor Alpha in a Tristetraprolin-Dependent Manner.

Mattijssen S, Maraia RJ.

Mol Cell Biol. 2015 Dec 7;36(4):574-84. doi: 10.1128/MCB.00804-15.


The La-Related Proteins, a Family with Connections to Cancer.

Stavraka C, Blagden S.

Biomolecules. 2015 Oct 16;5(4):2701-22. doi: 10.3390/biom5042701. Review.


The La-related protein 1-specific domain repurposes HEAT-like repeats to directly bind a 5'TOP sequence.

Lahr RM, Mack SM, Héroux A, Blagden SP, Bousquet-Antonelli C, Deragon JM, Berman AJ.

Nucleic Acids Res. 2015 Sep 18;43(16):8077-88. doi: 10.1093/nar/gkv748. Epub 2015 Jul 22.

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