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NaV-igating the MAP from PACAP to excitement. Focus on "Activation of MEK/ERK signaling contributes to the PACAP-induced increase in guinea pig cardiac neuron excitability".

Currie KP.

Am J Physiol Cell Physiol. 2016 Oct 1;311(4):C641-C642. doi: 10.1152/ajpcell.00270.2016. No abstract available.


Activation of MEK/ERK signaling contributes to the PACAP-induced increase in guinea pig cardiac neuron excitability.

Tompkins JD, Clason TA, Hardwick JC, Girard BM, Merriam LA, May V, Parsons RL.

Am J Physiol Cell Physiol. 2016 Oct 1;311(4):C643-C651. doi: 10.1152/ajpcell.00164.2016.


Post-translational modifications of voltage-gated sodium channels in chronic pain syndromes.

Laedermann CJ, Abriel H, Decosterd I.

Front Pharmacol. 2015 Nov 5;6:263. doi: 10.3389/fphar.2015.00263. Review.


Antihyperalgesic effect of tetrodotoxin in rat models of persistent muscle pain.

Alvarez P, Levine JD.

Neuroscience. 2015 Dec 17;311:499-507. doi: 10.1016/j.neuroscience.2015.10.059.


Biological Roles of Resolvins and Related Substances in the Resolution of Pain.

Lim JY, Park CK, Hwang SW.

Biomed Res Int. 2015;2015:830930. doi: 10.1155/2015/830930. Review.


ERK2 Alone Drives Inflammatory Pain But Cooperates with ERK1 in Sensory Neuron Survival.

O'Brien DE, Alter BJ, Satomoto M, Morgan CD, Davidson S, Vogt SK, Norman ME, Gereau GB, Demaro JA 3rd, Landreth GE, Golden JP, Gereau RW 4th.

J Neurosci. 2015 Jun 24;35(25):9491-507. doi: 10.1523/JNEUROSCI.4404-14.2015.


Characterisation of pain responses in the high fat diet/streptozotocin model of diabetes and the analgesic effects of antidiabetic treatments.

Byrne FM, Cheetham S, Vickers S, Chapman V.

J Diabetes Res. 2015;2015:752481. doi: 10.1155/2015/752481.


Protease-activated receptor 2 activation is sufficient to induce the transition to a chronic pain state.

Tillu DV, Hassler SN, Burgos-Vega CC, Quinn TL, Sorge RE, Dussor G, Boitano S, Vagner J, Price TJ.

Pain. 2015 May;156(5):859-67. doi: 10.1097/j.pain.0000000000000125.


Doxorubicin attenuates serotonin-induced long-term synaptic facilitation by phosphorylation of p38 mitogen-activated protein kinase.

Liu RY, Zhang Y, Coughlin BL, Cleary LJ, Byrne JH.

J Neurosci. 2014 Oct 1;34(40):13289-300. doi: 10.1523/JNEUROSCI.0538-14.2014.


Protein kinase C enhances human sodium channel hNav1.7 resurgent currents via a serine residue in the domain III-IV linker.

Tan ZY, Priest BT, Krajewski JL, Knopp KL, Nisenbaum ES, Cummins TR.

FEBS Lett. 2014 Nov 3;588(21):3964-9. doi: 10.1016/j.febslet.2014.09.011.


Regulation of alternative VEGF-A mRNA splicing is a therapeutic target for analgesia.

Hulse RP, Beazley-Long N, Hua J, Kennedy H, Prager J, Bevan H, Qiu Y, Fernandes ES, Gammons MV, Ballmer-Hofer K, Gittenberger de Groot AC, Churchill AJ, Harper SJ, Brain SD, Bates DO, Donaldson LF.

Neurobiol Dis. 2014 Nov;71:245-59. doi: 10.1016/j.nbd.2014.08.012.


Targeting voltage gated sodium channels NaV1.7, Na V1.8, and Na V1.9 for treatment of pathological cough.

Muroi Y, Undem BJ.

Lung. 2014 Feb;192(1):15-20. doi: 10.1007/s00408-013-9533-x. Review.


Pathobiology and management of prostate cancer-induced bone pain: recent insights and future treatments.

Muralidharan A, Smith MT.

Inflammopharmacology. 2013 Oct;21(5):339-63. doi: 10.1007/s10787-013-0183-7. Review.


AMPK: An emerging target for modification of injury-induced pain plasticity.

Price TJ, Dussor G.

Neurosci Lett. 2013 Dec 17;557 Pt A:9-18. doi: 10.1016/j.neulet.2013.06.060. Review.


mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK.

Melemedjian OK, Khoutorsky A, Sorge RE, Yan J, Asiedu MN, Valdez A, Ghosh S, Dussor G, Mogil JS, Sonenberg N, Price TJ.

Pain. 2013 Jul;154(7):1080-91. doi: 10.1016/j.pain.2013.03.021.

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