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Items: 15


The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase.

White PJ, McGarrah RW, Grimsrud PA, Tso SC, Yang WH, Haldeman JM, Grenier-Larouche T, An J, Lapworth AL, Astapova I, Hannou SA, George T, Arlotto M, Olson LB, Lai M, Zhang GF, Ilkayeva O, Herman MA, Wynn RM, Chuang DT, Newgard CB.

Cell Metab. 2018 Jun 5;27(6):1281-1293.e7. doi: 10.1016/j.cmet.2018.04.015. Epub 2018 May 17.


Delayed apoptosis allows islet β-cells to implement an autophagic mechanism to promote cell survival.

Hayes HL, Peterson BS, Haldeman JM, Newgard CB, Hohmeier HE, Stephens SB.

PLoS One. 2017 Feb 17;12(2):e0172567. doi: 10.1371/journal.pone.0172567. eCollection 2017.


A Pdx-1-Regulated Soluble Factor Activates Rat and Human Islet Cell Proliferation.

Hayes HL, Zhang L, Becker TC, Haldeman JM, Stephens SB, Arlotto M, Moss LG, Newgard CB, Hohmeier HE.

Mol Cell Biol. 2016 Nov 14;36(23):2918-2930. Print 2016 Dec 1.


Cdk5r1 Overexpression Induces Primary β-Cell Proliferation.

Draney C, Hobson AE, Grover SG, Jack BO, Tessem JS.

J Diabetes Res. 2016;2016:6375804. doi: 10.1155/2016/6375804. Epub 2015 Dec 14.


Cholecystokinin expression in the β-cell leads to increased β-cell area in aged mice and protects from streptozotocin-induced diabetes and apoptosis.

Lavine JA, Kibbe CR, Baan M, Sirinvaravong S, Umhoefer HM, Engler KA, Meske LM, Sacotte KA, Erhardt DP, Davis DB.

Am J Physiol Endocrinol Metab. 2015 Nov 15;309(10):E819-28. doi: 10.1152/ajpendo.00159.2015. Epub 2015 Sep 22.


Aurora Kinase A is critical for the Nkx6.1 mediated β-cell proliferation pathway.

Hobson A, Draney C, Stratford A, Becker TC, Lu D, Arlotto M, Tessem JS.

Islets. 2015;7(1):e1027854. doi: 10.1080/19382014.2015.1027854. Epub 2015 Jun 1.


Pdx-1 activates islet α- and β-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2.

Hayes HL, Moss LG, Schisler JC, Haldeman JM, Zhang Z, Rosenberg PB, Newgard CB, Hohmeier HE.

Mol Cell Biol. 2013 Oct;33(20):4017-29. doi: 10.1128/MCB.00469-13. Epub 2013 Aug 12.


Nox4- and Nox2-dependent oxidant production is required for VEGF-induced SERCA cysteine-674 S-glutathiolation and endothelial cell migration.

Evangelista AM, Thompson MD, Bolotina VM, Tong X, Cohen RA.

Free Radic Biol Med. 2012 Dec 15;53(12):2327-34. doi: 10.1016/j.freeradbiomed.2012.10.546. Epub 2012 Oct 23.


Overexpression of hepatocyte nuclear factor-4α initiates cell cycle entry, but is not sufficient to promote β-cell expansion in human islets.

Rieck S, Zhang J, Li Z, Liu C, Naji A, Takane KK, Fiaschi-Taesch NM, Stewart AF, Kushner JA, Kaestner KH.

Mol Endocrinol. 2012 Sep;26(9):1590-602. doi: 10.1210/me.2012-1019. Epub 2012 Jul 13.


A simple matter of life and death-the trials of postnatal Beta-cell mass regulation.

Tarabra E, Pelengaris S, Khan M.

Int J Endocrinol. 2012;2012:516718. doi: 10.1155/2012/516718. Epub 2012 Apr 22.


Checkpoints in adenoviral production: cross-contamination and E1A.

Haeussler DJ, Evangelista AM, Burgoyne JR, Cohen RA, Bachschmid MM, Pimental DR.

PLoS One. 2011;6(8):e23160. doi: 10.1371/journal.pone.0023160. Epub 2011 Aug 3.


MafA and MafB activity in pancreatic β cells.

Hang Y, Stein R.

Trends Endocrinol Metab. 2011 Sep;22(9):364-73. doi: 10.1016/j.tem.2011.05.003. Epub 2011 Jun 28. Review.


Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6.

Fiaschi-Taesch NM, Salim F, Kleinberger J, Troxell R, Cozar-Castellano I, Selk K, Cherok E, Takane KK, Scott DK, Stewart AF.

Diabetes. 2010 Aug;59(8):1926-36. doi: 10.2337/db09-1776.


FoxM1 is up-regulated by obesity and stimulates beta-cell proliferation.

Davis DB, Lavine JA, Suhonen JI, Krautkramer KA, Rabaglia ME, Sperger JM, Fernandez LA, Yandell BS, Keller MP, Wang IM, Schadt EE, Attie AD.

Mol Endocrinol. 2010 Sep;24(9):1822-34. doi: 10.1210/me.2010-0082. Epub 2010 Jul 21.


Cholecystokinin is up-regulated in obese mouse islets and expands beta-cell mass by increasing beta-cell survival.

Lavine JA, Raess PW, Stapleton DS, Rabaglia ME, Suhonen JI, Schueler KL, Koltes JE, Dawson JA, Yandell BS, Samuelson LC, Beinfeld MC, Davis DB, Hellerstein MK, Keller MP, Attie AD.

Endocrinology. 2010 Aug;151(8):3577-88. doi: 10.1210/en.2010-0233. Epub 2010 Jun 9.

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