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Items: 1 to 20 of 215


Empirical verification of evolutionary theories of aging.

Kyryakov P, Gomez-Perez A, Glebov A, Asbah N, Bruno L, Meunier C, Iouk T, Titorenko VI.

Aging (Albany NY). 2016 Oct 25;8(10):2568-2589. doi: 10.18632/aging.101090.


Impaired autophagy activity is linked to elevated ER-stress and inflammation in aging adipose tissue.

Ghosh AK, Mau T, O'Brien M, Garg S, Yung R.

Aging (Albany NY). 2016 Oct 24;8(10):2525-2537. doi: 10.18632/aging.101083.


Identification, Characterization and Expression of Methuselah-Like Genes in Dastarcus helophoroides (Coleoptera: Bothrideridae).

Zhang Z, Wang H, Hao C, Zhang W, Yang M, Chang Y, Li M.

Genes (Basel). 2016 Oct 21;7(10). pii: E91.


The role of hydrogen sulfide in aging and age-related pathologies.

Perridon BW, Leuvenink HG, Hillebrands JL, van Goor H, Bos EM.

Aging (Albany NY). 2016 Sep 27;8(10):2264-2289. doi: 10.18632/aging.101026.


Better Living through Chemistry: Caloric Restriction (CR) and CR Mimetics Alter Genome Function to Promote Increased Health and Lifespan.

Gillespie ZE, Pickering J, Eskiw CH.

Front Genet. 2016 Aug 18;7:142. doi: 10.3389/fgene.2016.00142. Review.


Insulin signaling controls neurotransmission via the 4eBP-dependent modification of the exocytotic machinery.

Mahoney RE, Azpurua J, Eaton BA.

Elife. 2016 Aug 15;5. pii: e16807. doi: 10.7554/eLife.16807.


Insulin signalling mediates the response to male-induced harm in female Drosophila melanogaster.

Sepil I, Carazo P, Perry JC, Wigby S.

Sci Rep. 2016 Jul 26;6:30205. doi: 10.1038/srep30205.


Mammalian Target of Rapamycin: Its Role in Early Neural Development and in Adult and Aged Brain Function.

Garza-Lombó C, Gonsebatt ME.

Front Cell Neurosci. 2016 Jun 16;10:157. doi: 10.3389/fncel.2016.00157. Review.


Pharmaceutical inhibition of mTOR in the common marmoset: effect of rapamycin on regulators of proteostasis in a non-human primate.

Lelegren M, Liu Y, Ross C, Tardif S, Salmon AB.

Pathobiol Aging Age Relat Dis. 2016 Jun 23;6:31793. doi: 10.3402/pba.v6.31793.


Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila.

Parkhitko AA, Binari R, Zhang N, Asara JM, Demontis F, Perrimon N.

Genes Dev. 2016 Jun 15;30(12):1409-22. doi: 10.1101/gad.282277.116.


The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.

Kennedy BK, Lamming DW.

Cell Metab. 2016 Jun 14;23(6):990-1003. doi: 10.1016/j.cmet.2016.05.009. Review.


Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island.

Arriola Apelo SI, Lamming DW.

J Gerontol A Biol Sci Med Sci. 2016 Jul;71(7):841-9. doi: 10.1093/gerona/glw090. Review.


The Extracellular-Regulated Kinase Effector Lk6 is Required for Glutamate Receptor Localization at the Drosophila Neuromuscular Junction.

Hussein NA, Delaney TL, Tounsel BL, Liebl FL.

J Exp Neurosci. 2016 May 11;10:77-91. doi: 10.4137/JEN.S32840.


Rapamycin slows down gut aging.

Gaur U, Fan X, Yang M.

Aging (Albany NY). 2016 May;8(5):833-4. doi: 10.18632/aging.100963. No abstract available.


Geroscience approaches to increase healthspan and slow aging.

Melov S.

F1000Res. 2016 Apr 29;5. pii: F1000 Faculty Rev-785. doi: 10.12688/f1000research.7583.1. Review.


Comparative idiosyncrasies in life extension by reduced mTOR signalling and its distinctiveness from dietary restriction.

Garratt M, Nakagawa S, Simons MJ.

Aging Cell. 2016 Aug;15(4):737-43. doi: 10.1111/acel.12489.


Evidence that hematopoietic stem cell function is preserved during aging in long-lived S6K1 mutant mice.

Selman C, Sinclair A, Pedroni SM, Irvine EE, Michie AM, Withers DJ.

Oncotarget. 2016 May 24;7(21):29937-43. doi: 10.18632/oncotarget.8729.


Inhibition of the Mechanistic Target of Rapamycin (mTOR)-Rapamycin and Beyond.

Lamming DW.

Cold Spring Harb Perspect Med. 2016 May 2;6(5). pii: a025924. doi: 10.1101/cshperspect.a025924. Review.


Potential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria-related disorders.

Evangelisti C, Cenni V, Lattanzi G.

Br J Clin Pharmacol. 2016 Nov;82(5):1229-1244. doi: 10.1111/bcp.12928. Review.


Sex difference in pathology of the ageing gut mediates the greater response of female lifespan to dietary restriction.

Regan JC, Khericha M, Dobson AJ, Bolukbasi E, Rattanavirotkul N, Partridge L.

Elife. 2016 Feb 16;5:e10956. doi: 10.7554/eLife.10956.

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