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Ubiquilin/Dsk2 promotes inclusion body formation and vacuole (lysosome)-mediated disposal of mutated huntingtin.

Chuang KH, Liang F, Higgins R, Wang Y.

Mol Biol Cell. 2016 Jul 1;27(13):2025-36. doi: 10.1091/mbc.E16-01-0026. Epub 2016 May 11.


Parkin Protects Against Misfolded SOD1 Toxicity by Promoting Its Aggresome Formation and Autophagic Clearance.

Yung C, Sha D, Li L, Chin LS.

Mol Neurobiol. 2015 Nov 13. [Epub ahead of print]


SOD1 aggregation in ALS mice shows simplistic test tube behavior.

Lang L, Zetterström P, Brännström T, Marklund SL, Danielsson J, Oliveberg M.

Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):9878-83. doi: 10.1073/pnas.1503328112. Epub 2015 Jul 28.


LK6/Mnk2a is a new kinase of alpha synuclein phosphorylation mediating neurodegeneration.

Zhang S, Xie J, Xia Y, Yu S, Gu Z, Feng R, Luo G, Wang D, Wang K, Jiang M, Cheng X, Huang H, Zhang W, Wen T.

Sci Rep. 2015 Jul 29;5:12564. doi: 10.1038/srep12564.


Accumulation of the PX domain mutant Frank-ter Haar syndrome protein Tks4 in aggresomes.

Ádám C, Fekete A, Bőgel G, Németh Z, Tőkési N, Ovádi J, Liliom K, Pesti S, Geiszt M, Buday L.

Cell Commun Signal. 2015 Jul 17;13:33. doi: 10.1186/s12964-015-0108-8.


Cytoplasmic dynein is required for the spatial organization of protein aggregates in filamentous fungi.

Egan MJ, McClintock MA, Hollyer IH, Elliott HL, Reck-Peterson SL.

Cell Rep. 2015 Apr 14;11(2):201-9.


Misfolded proteins: from little villains to little helpers in the fight against cancer.

Brüning A, Jückstock J.

Front Oncol. 2015 Feb 24;5:47. doi: 10.3389/fonc.2015.00047. eCollection 2015. Review.


Parkin-mediated K63-polyubiquitination targets ubiquitin C-terminal hydrolase L1 for degradation by the autophagy-lysosome system.

McKeon JE, Sha D, Li L, Chin LS.

Cell Mol Life Sci. 2015 May;72(9):1811-24. doi: 10.1007/s00018-014-1781-2. Epub 2014 Nov 18.


Versatile roles of k63-linked ubiquitin chains in trafficking.

Erpapazoglou Z, Walker O, Haguenauer-Tsapis R.

Cells. 2014 Nov 12;3(4):1027-88. doi: 10.3390/cells3041027. Review.


Synergistic effects on dopamine cell death in a Drosophila model of chronic toxin exposure.

Martin CA, Barajas A, Lawless G, Lawal HO, Assani K, Lumintang YP, Nunez V, Krantz DE.

Neurotoxicology. 2014 Sep;44:344-51. doi: 10.1016/j.neuro.2014.08.005. Epub 2014 Aug 23.


14-3-3 and aggresome formation: implications in neurodegenerative diseases.

Jia B, Wu Y, Zhou Y.

Prion. 2014 Mar-Apr;8(2). pii: 28123. Epub 2014 Feb 18. Review.


14-3-3 protein targets misfolded chaperone-associated proteins to aggresomes.

Xu Z, Graham K, Foote M, Liang F, Rizkallah R, Hurt M, Wang Y, Wu Y, Zhou Y.

J Cell Sci. 2013 Sep 15;126(Pt 18):4173-86. doi: 10.1242/jcs.126102. Epub 2013 Jul 10.


HIPK2 catalytic activity and subcellular localization are regulated by activation-loop Y354 autophosphorylation.

Siepi F, Gatti V, Camerini S, Crescenzi M, Soddu S.

Biochim Biophys Acta. 2013 Jun;1833(6):1443-53. doi: 10.1016/j.bbamcr.2013.02.018. Epub 2013 Feb 26.


Identification of the ubiquitin ligase Triad1 as a regulator of endosomal transport.

Hassink G, Slotman J, Oorschot V, Van Der Reijden BA, Monteferrario D, Noordermeer SM, Van Kerkhof P, Klumperman J, Strous GJ.

Biol Open. 2012 Jun 15;1(6):607-14. doi: 10.1242/bio.2012778. Epub 2012 May 9.


Severe growth deficiency is associated with STAT5b mutations that disrupt protein folding and activity.

Varco-Merth B, Feigerlová E, Shinde U, Rosenfeld RG, Hwa V, Rotwein P.

Mol Endocrinol. 2013 Jan;27(1):150-61. doi: 10.1210/me.2012-1275. Epub 2012 Nov 16.


CDC48 function during TMV infection: regulation of virus movement and replication by degradation?

Niehl A, Amari K, Heinlein M.

Plant Signal Behav. 2013 Feb;8(2):e22865. doi: 10.4161/psb.22865. Epub 2012 Nov 15.


CYLD, a deubiquitinase specific for lysine63-linked polyubiquitins, accumulates at the postsynaptic density in an activity-dependent manner.

Dosemeci A, Thein S, Yang Y, Reese TS, Tao-Cheng JH.

Biochem Biophys Res Commun. 2013 Jan 4;430(1):245-9. doi: 10.1016/j.bbrc.2012.10.131. Epub 2012 Nov 9.


Parkin prevents cortical atrophy and Aβ-induced alterations of brain metabolism: ¹³C NMR and magnetic resonance imaging studies in AD models.

Algarzae N, Hebron M, Miessau M, Moussa CE.

Neuroscience. 2012 Dec 6;225:22-34. doi: 10.1016/j.neuroscience.2012.08.057. Epub 2012 Sep 6.


Human stefin B normal and patho-physiological role: molecular and cellular aspects of amyloid-type aggregation of certain EPM1 mutants.

Polajnar M, Ceru S, Kopitar-Jerala N, Zerovnik E.

Front Mol Neurosci. 2012 Aug 24;5:88. doi: 10.3389/fnmol.2012.00088. eCollection 2012.

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