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Items: 1 to 20 of 123

1.

Too much of a good thing: How modulating LTB4 actions restore host defense in homeostasis or disease.

Brandt SL, Serezani CH.

Semin Immunol. 2017 Oct;33:37-43. doi: 10.1016/j.smim.2017.08.006. Review.

PMID:
29042027
2.

Progranulin gene delivery reduces plaque burden and synaptic atrophy in a mouse model of Alzheimer's disease.

Van Kampen JM, Kay DG.

PLoS One. 2017 Aug 24;12(8):e0182896. doi: 10.1371/journal.pone.0182896. eCollection 2017.

3.

Progranulin deficiency causes impairment of autophagy and TDP-43 accumulation.

Chang MC, Srinivasan K, Friedman BA, Suto E, Modrusan Z, Lee WP, Kaminker JS, Hansen DV, Sheng M.

J Exp Med. 2017 Sep 4;214(9):2611-2628. doi: 10.1084/jem.20160999. Epub 2017 Aug 4.

PMID:
28778989
4.

Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice.

Klein ZA, Takahashi H, Ma M, Stagi M, Zhou M, Lam TT, Strittmatter SM.

Neuron. 2017 Jul 19;95(2):281-296.e6. doi: 10.1016/j.neuron.2017.06.026.

PMID:
28728022
5.

Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations.

Zhou X, Sun L, Bracko O, Choi JW, Jia Y, Nana AL, Brady OA, Hernandez JCC, Nishimura N, Seeley WW, Hu F.

Nat Commun. 2017 May 25;8:15277. doi: 10.1038/ncomms15277.

6.

Function and Dysfunction of Microglia during Brain Development: Consequences for Synapses and Neural Circuits.

Paolicelli RC, Ferretti MT.

Front Synaptic Neurosci. 2017 May 10;9:9. doi: 10.3389/fnsyn.2017.00009. eCollection 2017. Review.

7.

White matter hyperintensities are seen only in GRN mutation carriers in the GENFI cohort.

Sudre CH, Bocchetta M, Cash D, Thomas DL, Woollacott I, Dick KM, van Swieten J, Borroni B, Galimberti D, Masellis M, Tartaglia MC, Rowe JB, Graff C, Tagliavini F, Frisoni G, Laforce R Jr, Finger E, de Mendonça A, Sorbi S, Ourselin S, Cardoso MJ, Rohrer JD; Genetic FTD Initiative, GENFI.

Neuroimage Clin. 2017 Apr 26;15:171-180. doi: 10.1016/j.nicl.2017.04.015. eCollection 2017.

8.

Accumulation of multiple neurodegenerative disease-related proteins in familial frontotemporal lobar degeneration associated with granulin mutation.

Hosokawa M, Kondo H, Serrano GE, Beach TG, Robinson AC, Mann DM, Akiyama H, Hasegawa M, Arai T.

Sci Rep. 2017 May 4;7(1):1513. doi: 10.1038/s41598-017-01587-6.

9.

Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia.

Krabbe G, Minami SS, Etchegaray JI, Taneja P, Djukic B, Davalos D, Le D, Lo I, Zhan L, Reichert MC, Sayed F, Merlini M, Ward ME, Perry DC, Lee SE, Sias A, Parkhurst CN, Gan WB, Akassoglou K, Miller BL, Farese RV Jr, Gan L.

Proc Natl Acad Sci U S A. 2017 May 9;114(19):5029-5034. doi: 10.1073/pnas.1700477114. Epub 2017 Apr 24.

10.

Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.

Ward ME, Chen R, Huang HY, Ludwig C, Telpoukhovskaia M, Taubes A, Boudin H, Minami SS, Reichert M, Albrecht P, Gelfand JM, Cruz-Herranz A, Cordano C, Alavi MV, Leslie S, Seeley WW, Miller BL, Bigio E, Mesulam MM, Bogyo MS, Mackenzie IR, Staropoli JF, Cotman SL, Huang EJ, Gan L, Green AJ.

Sci Transl Med. 2017 Apr 12;9(385). pii: eaah5642. doi: 10.1126/scitranslmed.aah5642.

11.

Neurotrophic effects of progranulin in vivo in reversing motor neuron defects caused by over or under expression of TDP-43 or FUS.

Chitramuthu BP, Kay DG, Bateman A, Bennett HP.

PLoS One. 2017 Mar 30;12(3):e0174784. doi: 10.1371/journal.pone.0174784. eCollection 2017.

12.

Progranulin and Its Related MicroRNAs after Status Epilepticus: Possible Mechanisms of Neuroprotection.

Körtvelyessy P, Huchtemann T, Heinze HJ, Bittner DM.

Int J Mol Sci. 2017 Feb 24;18(3). pii: E490. doi: 10.3390/ijms18030490. Review.

13.

Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network.

Takahashi H, Klein ZA, Bhagat SM, Kaufman AC, Kostylev MA, Ikezu T, Strittmatter SM; Alzheimer’s Disease Neuroimaging Initiative.

Acta Neuropathol. 2017 May;133(5):785-807. doi: 10.1007/s00401-017-1668-z. Epub 2017 Jan 9.

PMID:
28070672
14.

Foxo4- and Stat3-dependent IL-10 production by progranulin in regulatory T cells restrains inflammatory arthritis.

Fu W, Hu W, Shi L, Mundra JJ, Xiao G, Dustin ML, Liu CJ.

FASEB J. 2017 Apr;31(4):1354-1367. doi: 10.1096/fj.201601134R. Epub 2016 Dec 23.

PMID:
28011648
15.

Progranulin promotes peripheral nerve regeneration and reinnervation: role of notch signaling.

Altmann C, Vasic V, Hardt S, Heidler J, Häussler A, Wittig I, Schmidt MH, Tegeder I.

Mol Neurodegener. 2016 Oct 22;11(1):69.

16.

Progranulin Controls Sepsis via C/EBPα-Regulated Il10 Transcription and Ubiquitin Ligase/Proteasome-Mediated Protein Degradation.

Yan W, Ding A, Kim HJ, Zheng H, Wei F, Ma X.

J Immunol. 2016 Oct 15;197(8):3393-3405. Epub 2016 Sep 12.

17.

Role of the IL-1 Pathway in Dopaminergic Neurodegeneration and Decreased Voluntary Movement.

Stojakovic A, Paz-Filho G, Arcos-Burgos M, Licinio J, Wong ML, Mastronardi CA.

Mol Neurobiol. 2017 Aug;54(6):4486-4495. doi: 10.1007/s12035-016-9988-x. Epub 2016 Jun 29.

18.

Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia.

Holler CJ, Taylor G, McEachin ZT, Deng Q, Watkins WJ, Hudson K, Easley CA, Hu WT, Hales CM, Rossoll W, Bassell GJ, Kukar T.

Mol Neurodegener. 2016 Jun 24;11(1):46. doi: 10.1186/s13024-016-0114-3.

19.

Reduced miR-659-3p Levels Correlate with Progranulin Increase in Hypoxic Conditions: Implications for Frontotemporal Dementia.

Piscopo P, Grasso M, Fontana F, Crestini A, Puopolo M, Del Vescovo V, Venerosi A, Calamandrei G, Vencken SF, Greene CM, Confaloni A, Denti MA.

Front Mol Neurosci. 2016 May 3;9:31. doi: 10.3389/fnmol.2016.00031. eCollection 2016.

20.

Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation.

Lui H, Zhang J, Makinson SR, Cahill MK, Kelley KW, Huang HY, Shang Y, Oldham MC, Martens LH, Gao F, Coppola G, Sloan SA, Hsieh CL, Kim CC, Bigio EH, Weintraub S, Mesulam MM, Rademakers R, Mackenzie IR, Seeley WW, Karydas A, Miller BL, Borroni B, Ghidoni R, Farese RV Jr, Paz JT, Barres BA, Huang EJ.

Cell. 2016 May 5;165(4):921-35. doi: 10.1016/j.cell.2016.04.001. Epub 2016 Apr 21.

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