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Items: 1 to 20 of 51

1.

MiR-661 promotes tumor invasion and metastasis by directly inhibiting RB1 in non small cell lung cancer.

Liu F, Cai Y, Rong X, Chen J, Zheng D, Chen L, Zhang J, Luo R, Zhao P, Ruan J.

Mol Cancer. 2017 Jul 17;16(1):122. doi: 10.1186/s12943-017-0698-4.

2.

Retinoblastoma cells activate the AKT pathway and are vulnerable to the PI3K/mTOR inhibitor NVP-BEZ235.

Xie C, Freeman MJ, Lu H, Wang X, Forster CL, Sarver AL, Hallstrom TC.

Oncotarget. 2017 Jun 13;8(24):38084-38098. doi: 10.18632/oncotarget.16970.

3.

Induction of G2M Arrest by Flavokawain A, a Kava Chalcone, Increases the Responsiveness of HER2-Overexpressing Breast Cancer Cells to Herceptin.

Jandial DD, Krill LS, Chen L, Wu C, Ke Y, Xie J, Hoang BH, Zi X.

Molecules. 2017 Mar 14;22(3). pii: E462. doi: 10.3390/molecules22030462.

4.

Interchangeable Roles for E2F Transcriptional Repression by the Retinoblastoma Protein and p27KIP1-Cyclin-Dependent Kinase Regulation in Cell Cycle Control and Tumor Suppression.

Thwaites MJ, Cecchini MJ, Passos DT, Welch I, Dick FA.

Mol Cell Biol. 2017 Jan 4;37(2). pii: e00561-16. doi: 10.1128/MCB.00561-16. Print 2017 Jan 15.

5.

MDM2 but not MDM4 promotes retinoblastoma cell proliferation through p53-independent regulation of MYCN translation.

Qi DL, Cobrinik D.

Oncogene. 2017 Mar 30;36(13):1760-1769. doi: 10.1038/onc.2016.350. Epub 2016 Oct 17.

6.

Drugging the addict: non-oncogene addiction as a target for cancer therapy.

Nagel R, Semenova EA, Berns A.

EMBO Rep. 2016 Nov;17(11):1516-1531. Epub 2016 Oct 4. Review.

7.

RB1: a prototype tumor suppressor and an enigma.

Dyson NJ.

Genes Dev. 2016 Jul 1;30(13):1492-502. doi: 10.1101/gad.282145.116. Review.

8.

Treating cancer when pRb and p53 cannot be reactivated.

Zhu L.

Mol Cell Oncol. 2015 May 5;2(4):e1004954. doi: 10.1080/23723556.2015.1004954. eCollection 2015 Oct-Dec.

9.

p27T187A knockin identifies Skp2/Cks1 pocket inhibitors for advanced prostate cancer.

Zhao H, Lu Z, Bauzon F, Fu H, Cui J, Locker J, Zhu L.

Oncogene. 2017 Jan 5;36(1):60-70. doi: 10.1038/onc.2016.175. Epub 2016 May 16.

10.

Retinoblastoma tumor suppressor functions shared by stem cell and cancer cell strategies.

Kohno S, Kitajima S, Sasaki N, Takahashi C.

World J Stem Cells. 2016 Apr 26;8(4):170-84. doi: 10.4252/wjsc.v8.i4.170. Review.

11.

Deletions of Retinoblastoma 1 (Rb1) and Its Repressing Target S Phase Kinase-associated protein 2 (Skp2) Are Synthetic Lethal in Mouse Embryogenesis.

Zhao H, Wang H, Bauzon F, Lu Z, Fu H, Cui J, Zhu L.

J Biol Chem. 2016 May 6;291(19):10201-9. doi: 10.1074/jbc.M116.718049. Epub 2016 Mar 10.

12.

Flavokawain A induces deNEDDylation and Skp2 degradation leading to inhibition of tumorigenesis and cancer progression in the TRAMP transgenic mouse model.

Li X, Yokoyama NN, Zhang S, Ding L, Liu HM, Lilly MB, Mercola D, Zi X.

Oncotarget. 2015 Dec 8;6(39):41809-24. doi: 10.18632/oncotarget.6166.

13.

Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis.

Heo J, Eki R, Abbas T.

Semin Cancer Biol. 2016 Feb;36:33-51. doi: 10.1016/j.semcancer.2015.09.015. Epub 2015 Sep 30. Review.

14.

Systemic Akt1 Deletion after Tumor Onset in p53(-/-) Mice Increases Lifespan and Regresses Thymic Lymphoma Emulating p53 Restoration.

Yu WN, Nogueira V, Sobhakumari A, Patra KC, Bhaskar PT, Hay N.

Cell Rep. 2015 Jul 28;12(4):610-21. doi: 10.1016/j.celrep.2015.06.057. Epub 2015 Jul 16.

15.

Substituting threonine 187 with alanine in p27Kip1 prevents pituitary tumorigenesis by two-hit loss of Rb1 and enhances humoral immunity in old age.

Zhao H, Bauzon F, Bi E, Yu JJ, Fu H, Lu Z, Cui J, Jeon H, Zang X, Ye BH, Zhu L.

J Biol Chem. 2015 Feb 27;290(9):5797-809. doi: 10.1074/jbc.M114.625350. Epub 2015 Jan 12.

16.

Antitumor mechanisms when pRb and p53 are genetically inactivated.

Zhu L, Lu Z, Zhao H.

Oncogene. 2015 Aug 27;34(35):4547-57. doi: 10.1038/onc.2014.399. Epub 2014 Dec 8. Review.

17.

The role of genetic and epigenetic changes in pituitary tumorigenesis.

Fukuoka H, Takahashi Y.

Neurol Med Chir (Tokyo). 2014;54(12):943-57. Epub 2014 Nov 29. Review.

18.

BCR-ABL1 promotes leukemia by converting p27 into a cytoplasmic oncoprotein.

Agarwal A, Mackenzie RJ, Besson A, Jeng S, Carey A, LaTocha DH, Fleischman AG, Duquesnes N, Eide CA, Vasudevan KB, Loriaux MM, Firpo E, Cortes JE, McWeeney S, O'Hare T, Roberts JM, Druker BJ, Deininger MW.

Blood. 2014 Nov 20;124(22):3260-73. doi: 10.1182/blood-2013-04-497040. Epub 2014 Oct 7.

19.

Rb suppresses human cone-precursor-derived retinoblastoma tumours.

Xu XL, Singh HP, Wang L, Qi DL, Poulos BK, Abramson DH, Jhanwar SC, Cobrinik D.

Nature. 2014 Oct 16;514(7522):385-8. doi: 10.1038/nature13813. Epub 2014 Sep 24.

20.

A retinoblastoma allele that is mutated at its common E2F interaction site inhibits cell proliferation in gene-targeted mice.

Cecchini MJ, Thwaites MJ, Talluri S, MacDonald JI, Passos DT, Chong JL, Cantalupo P, Stafford PM, Sáenz-Robles MT, Francis SM, Pipas JM, Leone G, Welch I, Dick FA.

Mol Cell Biol. 2014 Jun;34(11):2029-45. doi: 10.1128/MCB.01589-13. Epub 2014 Mar 24.

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