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A fourth subtype of retinoic acid receptor-related orphan receptors is activated by oxidized all-trans retinoic acid in medaka (Oryzias latipes).

Sakai K, Fukushima H, Yamamoto Y, Ikeuchi T.

Zoological Lett. 2017 Aug 11;3:11. doi: 10.1186/s40851-017-0074-7. eCollection 2017.


Seven perspectives on GPCR H/D-exchange proteomics methods.

Zhang X.

F1000Res. 2017 Jan 30;6:89. doi: 10.12688/f1000research.10667.1. eCollection 2017.


N-Arylsulfonyl Indolines as Retinoic Acid Receptor-Related Orphan Receptor γ (RORγ) Agonists.

Doebelin C, Patouret R, Garcia-Ordonez RD, Chang MR, Dharmarajan V, Kuruvilla DS, Novick SJ, Lin L, Cameron MD, Griffin PR, Kamenecka TM.

ChemMedChem. 2016 Dec 6;11(23):2607-2620. doi: 10.1002/cmdc.201600491. Epub 2016 Nov 23.


The therapeutic potential of RORγ modulators in the treatment of human disease.

Chang MR, Goswami D, Mercer BA, Griffin PR.

J Exp Pharmacol. 2012 Oct 11;4:141-8. doi: 10.2147/JEP.S27078. eCollection 2012. Review.


Perturbed rhythmic activation of signaling pathways in mice deficient for Sterol Carrier Protein 2-dependent diurnal lipid transport and metabolism.

Jouffe C, Gobet C, Martin E, Métairon S, Morin-Rivron D, Masoodi M, Gachon F.

Sci Rep. 2016 Apr 21;6:24631. doi: 10.1038/srep24631.


The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome.

He B, Nohara K, Park N, Park YS, Guillory B, Zhao Z, Garcia JM, Koike N, Lee CC, Takahashi JS, Yoo SH, Chen Z.

Cell Metab. 2016 Apr 12;23(4):610-21. doi: 10.1016/j.cmet.2016.03.007.


RORα and 25-Hydroxycholesterol Crosstalk Regulates Lipid Droplet Homeostasis in Macrophages.

Tuong ZK, Lau P, Du X, Condon ND, Goode JM, Oh TG, Yeo JC, Muscat GE, Stow JL.

PLoS One. 2016 Jan 26;11(1):e0147179. doi: 10.1371/journal.pone.0147179. eCollection 2016.


Synthetic RORγt Agonists Enhance Protective Immunity.

Chang MR, Dharmarajan V, Doebelin C, Garcia-Ordonez RD, Novick SJ, Kuruvilla DS, Kamenecka TM, Griffin PR.

ACS Chem Biol. 2016 Apr 15;11(4):1012-8. doi: 10.1021/acschembio.5b00899. Epub 2016 Jan 25.


Therapeutic Effect of a Synthetic RORα/γ Agonist in an Animal Model of Autism.

Wang Y, Billon C, Walker JK, Burris TP.

ACS Chem Neurosci. 2016 Feb 17;7(2):143-8. doi: 10.1021/acschemneuro.5b00159. Epub 2015 Dec 3.


Segregation of Clock and Non-Clock Regulatory Functions of REV-ERB.

Butler AA, Burris TP.

Cell Metab. 2015 Aug 4;22(2):197-8. doi: 10.1016/j.cmet.2015.07.014.


Discovery of Biaryl Amides as Potent, Orally Bioavailable, and CNS Penetrant RORγt Inhibitors.

Wang Y, Cai W, Cheng Y, Yang T, Liu Q, Zhang G, Meng Q, Han F, Huang Y, Zhou L, Xiang Z, Zhao YG, Xu Y, Cheng Z, Lu S, Wu Q, Xiang JN, Elliott JD, Leung S, Ren F, Lin X.

ACS Med Chem Lett. 2015 May 26;6(7):787-92. doi: 10.1021/acsmedchemlett.5b00122. eCollection 2015 Jul 9.


Less is More: Membrane Protein Digestion Beyond Urea-Trypsin Solution for Next-level Proteomics.

Zhang X.

Mol Cell Proteomics. 2015 Sep;14(9):2441-53. doi: 10.1074/mcp.R114.042572. Epub 2015 Jun 16. Review.


Identification of natural RORγ ligands that regulate the development of lymphoid cells.

Santori FR, Huang P, van de Pavert SA, Douglass EF Jr, Leaver DJ, Haubrich BA, Keber R, Lorbek G, Konijn T, Rosales BN, Rozman D, Horvat S, Rahier A, Mebius RE, Rastinejad F, Nes WD, Littman DR.

Cell Metab. 2015 Feb 3;21(2):286-97. doi: 10.1016/j.cmet.2015.01.004.


Transcription factor networks directing the development, function, and evolution of innate lymphoid effectors.

Kang J, Malhotra N.

Annu Rev Immunol. 2015;33:505-38. doi: 10.1146/annurev-immunol-032414-112025. Epub 2015 Jan 30. Review.


Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation.

Soroosh P, Wu J, Xue X, Song J, Sutton SW, Sablad M, Yu J, Nelen MI, Liu X, Castro G, Luna R, Crawford S, Banie H, Dandridge RA, Deng X, Bittner A, Kuei C, Tootoonchi M, Rozenkrants N, Herman K, Gao J, Yang XV, Sachen K, Ngo K, Fung-Leung WP, Nguyen S, de Leon-Tabaldo A, Blevitt J, Zhang Y, Cummings MD, Rao T, Mani NS, Liu C, McKinnon M, Milla ME, Fourie AM, Sun S.

Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12163-8. doi: 10.1073/pnas.1322807111. Epub 2014 Aug 4.


Oxysterols and their cellular effectors.

Olkkonen VM, Béaslas O, Nissilä E.

Biomolecules. 2012 Feb 15;2(1):76-103. doi: 10.3390/biom2010076.


Identification of New Nonsteroidal RORα Ligands; Related Structure-Activity Relationships and Docking Studies.

Dubernet M, Duguet N, Colliandre L, Berini C, Helleboid S, Bourotte M, Daillet M, Maingot L, Daix S, Delhomel JF, Morin-Allory L, Routier S, Walczak R.

ACS Med Chem Lett. 2013 Apr 10;4(6):504-8. doi: 10.1021/ml300471d. eCollection 2013 Jun 13.


RORα and ROR γ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy- and 20,23-dihydroxyvitamin D.

Slominski AT, Kim TK, Takeda Y, Janjetovic Z, Brozyna AA, Skobowiat C, Wang J, Postlethwaite A, Li W, Tuckey RC, Jetten AM.

FASEB J. 2014 Jul;28(7):2775-89. doi: 10.1096/fj.13-242040. Epub 2014 Mar 25.


REV-ERB and ROR nuclear receptors as drug targets.

Kojetin DJ, Burris TP.

Nat Rev Drug Discov. 2014 Mar;13(3):197-216. doi: 10.1038/nrd4100. Review.

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