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Items: 19

1.

PERK Activation Promotes Medulloblastoma Tumorigenesis by Attenuating Premalignant Granule Cell Precursor Apoptosis.

Ho Y, Li X, Jamison S, Harding HP, McKinnon PJ, Ron D, Lin W.

Am J Pathol. 2016 Jul;186(7):1939-51. doi: 10.1016/j.ajpath.2016.03.004. Epub 2016 May 12.

2.

NCOA3 coactivator is a transcriptional target of XBP1 and regulates PERK-eIF2α-ATF4 signalling in breast cancer.

Gupta A, Hossain MM, Miller N, Kerin M, Callagy G, Gupta S.

Oncogene. 2016 Nov 10;35(45):5860-5871. doi: 10.1038/onc.2016.121. Epub 2016 Apr 25.

3.

Type I interferons mediate pancreatic toxicities of PERK inhibition.

Yu Q, Zhao B, Gui J, Katlinski KV, Brice A, Gao Y, Li C, Kushner JA, Koumenis C, Diehl JA, Fuchs SY.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15420-5. doi: 10.1073/pnas.1516362112. Epub 2015 Dec 1.

4.
5.

Cell intrinsic and extrinsic activators of the unfolded protein response in cancer: Mechanisms and targets for therapy.

Tameire F, Verginadis II, Koumenis C.

Semin Cancer Biol. 2015 Aug;33:3-15. doi: 10.1016/j.semcancer.2015.04.002. Epub 2015 Apr 25. Review.

6.

miR-211 suppresses epithelial ovarian cancer proliferation and cell-cycle progression by targeting Cyclin D1 and CDK6.

Xia B, Yang S, Liu T, Lou G.

Mol Cancer. 2015 Mar 11;14:57. doi: 10.1186/s12943-015-0322-4.

7.

The role of endoplasmic reticulum stress in human pathology.

Oakes SA, Papa FR.

Annu Rev Pathol. 2015;10:173-94. doi: 10.1146/annurev-pathol-012513-104649. Epub 2014 Oct 27. Review.

8.

Endoplasmic reticulum stress and cancer.

Yadav RK, Chae SW, Kim HR, Chae HJ.

J Cancer Prev. 2014 Jun;19(2):75-88. doi: 10.15430/JCP.2014.19.2.75. Review.

9.

Perk gene dosage regulates glucose homeostasis by modulating pancreatic β-cell functions.

Wang R, Munoz EE, Zhu S, McGrath BC, Cavener DR.

PLoS One. 2014 Jun 10;9(6):e99684. doi: 10.1371/journal.pone.0099684. eCollection 2014.

10.

Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration.

Bravo R, Parra V, Gatica D, Rodriguez AE, Torrealba N, Paredes F, Wang ZV, Zorzano A, Hill JA, Jaimovich E, Quest AF, Lavandero S.

Int Rev Cell Mol Biol. 2013;301:215-90. doi: 10.1016/B978-0-12-407704-1.00005-1. Review.

11.

ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth.

Hart LS, Cunningham JT, Datta T, Dey S, Tameire F, Lehman SL, Qiu B, Zhang H, Cerniglia G, Bi M, Li Y, Gao Y, Liu H, Li C, Maity A, Thomas-Tikhonenko A, Perl AE, Koong A, Fuchs SY, Diehl JA, Mills IG, Ruggero D, Koumenis C.

J Clin Invest. 2012 Dec;122(12):4621-34. doi: 10.1172/JCI62973. Epub 2012 Nov 12.

12.

miR-211 is a prosurvival microRNA that regulates chop expression in a PERK-dependent manner.

Chitnis NS, Pytel D, Bobrovnikova-Marjon E, Pant D, Zheng H, Maas NL, Frederick B, Kushner JA, Chodosh LA, Koumenis C, Fuchs SY, Diehl JA.

Mol Cell. 2012 Nov 9;48(3):353-64. doi: 10.1016/j.molcel.2012.08.025. Epub 2012 Sep 27.

13.

Endoplasmic reticulum stress, pancreatic β-cell degeneration, and diabetes.

Papa FR.

Cold Spring Harb Perspect Med. 2012 Sep 1;2(9):a007666. doi: 10.1101/cshperspect.a007666. Review.

14.

The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies.

Luo B, Lee AS.

Oncogene. 2013 Feb 14;32(7):805-18. doi: 10.1038/onc.2012.130. Epub 2012 Apr 16. Review.

15.

Hyperthermia induces the ER stress pathway.

Xu X, Gupta S, Hu W, McGrath BC, Cavener DR.

PLoS One. 2011;6(8):e23740. doi: 10.1371/journal.pone.0023740. Epub 2011 Aug 18.

16.

The cell biology of the unfolded protein response.

Diehl JA, Fuchs SY, Koumenis C.

Gastroenterology. 2011 Jul;141(1):38-41, 41.e1-2. doi: 10.1053/j.gastro.2011.05.018. Epub 2011 May 24. Review.

17.

PERK in beta cell biology and insulin biogenesis.

Cavener DR, Gupta S, McGrath BC.

Trends Endocrinol Metab. 2010 Dec;21(12):714-21. doi: 10.1016/j.tem.2010.08.005. Epub 2010 Sep 17. Review.

18.

PERK (EIF2AK3) regulates proinsulin trafficking and quality control in the secretory pathway.

Gupta S, McGrath B, Cavener DR.

Diabetes. 2010 Aug;59(8):1937-47. doi: 10.2337/db09-1064. Epub 2010 Jun 8.

19.

The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation.

Ye J, Kumanova M, Hart LS, Sloane K, Zhang H, De Panis DN, Bobrovnikova-Marjon E, Diehl JA, Ron D, Koumenis C.

EMBO J. 2010 Jun 16;29(12):2082-96. doi: 10.1038/emboj.2010.81. Epub 2010 May 14.

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