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Implication of combined PD-L1/PD-1 blockade with cytokine-induced killer cells as a synergistic immunotherapy for gastrointestinal cancer.

Dai C, Lin F, Geng R, Ge X, Tang W, Chang J, Wu Z, Liu X, Lin Y, Zhang Z, Li J.

Oncotarget. 2016 Mar 1;7(9):10332-44. doi: 10.18632/oncotarget.7243.


PD-L1 Expression on Retrovirus-Infected Cells Mediates Immune Escape from CD8+ T Cell Killing.

Akhmetzyanova I, Drabczyk M, Neff CP, Gibbert K, Dietze KK, Werner T, Liu J, Chen L, Lang KS, Palmer BE, Dittmer U, Zelinskyy G.

PLoS Pathog. 2015 Oct 20;11(10):e1005224. doi: 10.1371/journal.ppat.1005224. eCollection 2015 Oct. Erratum in: PLoS Pathog. 2015 Dec;11(12):e1005364.


Mechanisms of PD-L1/PD-1-mediated CD8 T-cell dysfunction in the context of aging-related immune defects in the Eµ-TCL1 CLL mouse model.

McClanahan F, Riches JC, Miller S, Day WP, Kotsiou E, Neuberg D, Croce CM, Capasso M, Gribben JG.

Blood. 2015 Jul 9;126(2):212-21. doi: 10.1182/blood-2015-02-626754. Epub 2015 May 15.


From humble beginnings to success in the clinic: Chimeric antigen receptor-modified T-cells and implications for immunotherapy.

Firor AE, Jares A, Ma Y.

Exp Biol Med (Maywood). 2015 Aug;240(8):1087-98. doi: 10.1177/1535370215584936. Epub 2015 May 7. Review.


Upregulation of Programmed Death-1 and Its Ligand in Cardiac Injury Models: Interaction with GADD153.

Baban B, Liu JY, Qin X, Weintraub NL, Mozaffari MS.

PLoS One. 2015 Apr 22;10(4):e0124059. doi: 10.1371/journal.pone.0124059. eCollection 2015.


Enhanced CD8 T cell responses through GITR-mediated costimulation resolve chronic viral infection.

Pascutti MF, Geerman S, Slot E, van Gisbergen KP, Boon L, Arens R, van Lier RA, Wolkers MC, Nolte MA.

PLoS Pathog. 2015 Mar 4;11(3):e1004675. doi: 10.1371/journal.ppat.1004675. eCollection 2015 Mar.


Type 1 interferon-induced IL-7 maintains CD8+ T-cell responses and homeostasis by suppressing PD-1 expression in viral hepatitis.

Hou L, Jie Z, Liang Y, Desai M, Soong L, Sun J.

Cell Mol Immunol. 2015 Mar;12(2):213-21. doi: 10.1038/cmi.2014.49. Epub 2014 Jul 14.


Cannabinoid receptor 2-63 QQ variant is associated with persistently normal aminotransferase serum levels in chronic hepatitis C.

Coppola N, Zampino R, Sagnelli C, Bellini G, Marrone A, Stanzione M, Capoluongo N, Boemio A, Minichini C, Adinolfi LE, Maione S, Del Giudice EM, Sagnelli E, Rossi F.

PLoS One. 2014 Jun 18;9(6):e99450. doi: 10.1371/journal.pone.0099450. eCollection 2014.


Epigenetic manipulation restores functions of defective CD8⁺ T cells from chronic viral infection.

Zhang F, Zhou X, DiSpirito JR, Wang C, Wang Y, Shen H.

Mol Ther. 2014 Sep;22(9):1698-706. doi: 10.1038/mt.2014.91. Epub 2014 May 27.


HTLV-1 specific CD8+ T cell function augmented by blockade of 2B4/CD48 interaction in HTLV-1 infection.

Ezinne CC, Yoshimitsu M, White Y, Arima N.

PLoS One. 2014 Feb 5;9(2):e87631. doi: 10.1371/journal.pone.0087631. eCollection 2014.


Reactivation of human polyomaviruses in immunocompromised states.

Wiedinger K, Bitsaktsis C, Chang S.

J Neurovirol. 2014 Feb;20(1):1-8. doi: 10.1007/s13365-014-0234-x. Epub 2014 Jan 31.


Direct effects of hepatitis C virus on the lymphoid cells.

Kondo Y, Shimosegawa T.

World J Gastroenterol. 2013 Nov 28;19(44):7889-95. doi: 10.3748/wjg.v19.i44.7889. Review.


CD8+ memory T cells appear exhausted within hours of acute virus infection.

Hosking MP, Flynn CT, Botten J, Whitton JL.

J Immunol. 2013 Oct 15;191(8):4211-22. doi: 10.4049/jimmunol.1300920. Epub 2013 Sep 11.


Mucosal immunology of HIV infection.

Xu H, Wang X, Veazey RS.

Immunol Rev. 2013 Jul;254(1):10-33. doi: 10.1111/imr.12072. Review.


Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors.

Duraiswamy J, Kaluza KM, Freeman GJ, Coukos G.

Cancer Res. 2013 Jun 15;73(12):3591-603. doi: 10.1158/0008-5472.CAN-12-4100. Epub 2013 Apr 30.


Strength of PD-1 signaling differentially affects T-cell effector functions.

Wei F, Zhong S, Ma Z, Kong H, Medvec A, Ahmed R, Freeman GJ, Krogsgaard M, Riley JL.

Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2480-9. doi: 10.1073/pnas.1305394110. Epub 2013 Apr 22.


Apoptosis - an Ubiquitous T cell Immunomodulator.

Murali AK, Mehrotra S.

J Clin Cell Immunol. 2011 Dec 10;S3:2.


Programmed death 1 protects from fatal circulatory failure during systemic virus infection of mice.

Frebel H, Nindl V, Schuepbach RA, Braunschweiler T, Richter K, Vogel J, Wagner CA, Loffing-Cueni D, Kurrer M, Ludewig B, Oxenius A.

J Exp Med. 2012 Dec 17;209(13):2485-99. doi: 10.1084/jem.20121015. Epub 2012 Dec 10.


Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection.

Paley MA, Kroy DC, Odorizzi PM, Johnnidis JB, Dolfi DV, Barnett BE, Bikoff EK, Robertson EJ, Lauer GM, Reiner SL, Wherry EJ.

Science. 2012 Nov 30;338(6111):1220-5. doi: 10.1126/science.1229620.


Seoul virus-infected rat lung endothelial cells and alveolar macrophages differ in their ability to support virus replication and induce regulatory T cell phenotypes.

Li W, Klein SL.

J Virol. 2012 Nov;86(21):11845-55. doi: 10.1128/JVI.01233-12. Epub 2012 Aug 22. Erratum in: J Virol. 2013 Jan;87(1):706.

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