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Items: 1 to 20 of 28


CUL4A overexpression as an independent adverse prognosticator in intrahepatic cholangiocarcinoma.

Huang G-, Liu TT, Weng SW, You HL, Wei YC, Chen CH, Eng HL, Huang WT.

BMC Cancer. 2017 Jun 2;17(1):395. doi: 10.1186/s12885-017-3389-z.


Cullin 4A is associated with epithelial to mesenchymal transition and poor prognosis in perihilar cholangiocarcinoma.

Zhang TJ, Xue D, Zhang CD, Zhang ZD, Liu QR, Wang JQ.

World J Gastroenterol. 2017 Apr 7;23(13):2318-2329. doi: 10.3748/wjg.v23.i13.2318.


Integrative analysis of multi-omics data reveals distinct impacts of DDB1-CUL4 associated factors in human lung adenocarcinomas.

Yan H, Bi L, Wang Y, Zhang X, Hou Z, Wang Q, Snijders AM, Mao JH.

Sci Rep. 2017 Mar 23;7(1):333. doi: 10.1038/s41598-017-00512-1.


CUL4A promotes proliferation and metastasis of colorectal cancer cells by regulating H3K4 trimethylation in epithelial-mesenchymal transition.

Sui X, Zhou H, Zhu L, Wang D, Fan S, Zhao W.

Onco Targets Ther. 2017 Feb 9;10:735-743. doi: 10.2147/OTT.S118897. eCollection 2017.


Dysregulation of CUL4A and CUL4B Ubiquitin Ligases in Lung Cancer.

Jia L, Yan F, Cao W, Chen Z, Zheng H, Li H, Pan Y, Narula N, Ren X, Li H, Zhou P.

J Biol Chem. 2017 Feb 17;292(7):2966-2978. doi: 10.1074/jbc.M116.765230. Epub 2016 Dec 14.


A new layer of degradation mechanism for PR-Set7/Set8 during cell cycle.

Zheng N, Dai X, Wang Z, Wei W.

Cell Cycle. 2016 Nov 16;15(22):3042-3047. Epub 2016 Sep 20.


Knockdown of cullin 4A inhibits growth and increases chemosensitivity in lung cancer cells.

Hung MS, Chen IC, You L, Jablons DM, Li YC, Mao JH, Xu Z, Lung JH, Yang CT, Liu ST.

J Cell Mol Med. 2016 Jul;20(7):1295-306. doi: 10.1111/jcmm.12811. Epub 2016 Mar 10.


Type 1 diabetes cadaveric human pancreata exhibit a unique exocrine tissue proteomic profile.

Liu CW, Atkinson MA, Zhang Q.

Proteomics. 2016 May;16(9):1432-46. doi: 10.1002/pmic.201500333. Epub 2016 Apr 13.


Dysregulation of ubiquitin ligases in cancer.

Qi J, Ronai ZA.

Drug Resist Updat. 2015 Nov;23:1-11. doi: 10.1016/j.drup.2015.09.001. Epub 2015 Sep 28. Review.


CUL4A facilitates hepatocarcinogenesis by promoting cell cycle progression and epithelial-mesenchymal transition.

Pan Y, Wang B, Yang X, Bai F, Xu Q, Li X, Gao L, Ma C, Liang X.

Sci Rep. 2015 Nov 23;5:17006. doi: 10.1038/srep17006.


The role and mechanism of CRL4 E3 ubiquitin ligase in cancer and its potential therapy implications.

Sang Y, Yan F, Ren X.

Oncotarget. 2015 Dec 15;6(40):42590-602. doi: 10.18632/oncotarget.6052. Review.


Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B.

Hannah J, Zhou P.

Gene. 2015 Nov 15;573(1):33-45. doi: 10.1016/j.gene.2015.08.064. Epub 2015 Sep 3. Review.


Analysis of lung tumor initiation and progression in transgenic mice for Cre-inducible overexpression of Cul4A gene.

Wang Y, Xu Z, Mao JH, Hung MS, Hsieh D, Au A, Jablons DM, You L.

Thorac Cancer. 2015 Jul;6(4):480-7. doi: 10.1111/1759-7714.12257. Epub 2015 Jun 8.


Cul4A overexpression associated with Gli1 expression in malignant pleural mesothelioma.

Yang YL, Ni J, Hsu PC, Mao JH, Hsieh D, Xu A, Chan G, Au A, Xu Z, Jablons DM, You L.

J Cell Mol Med. 2015 Oct;19(10):2385-96. doi: 10.1111/jcmm.12620. Epub 2015 Jul 27.


CUL4A overexpression enhances lung tumor growth and sensitizes lung cancer cells to erlotinib via transcriptional regulation of EGFR.

Wang Y, Zhang P, Liu Z, Wang Q, Wen M, Wang Y, Yuan H, Mao JH, Wei G.

Mol Cancer. 2014 Nov 21;13:252. doi: 10.1186/1476-4598-13-252.


CUL4A contributes to the biology of basal-like breast tumors through modulation of cell growth and antitumor immune response.

Saucedo-Cuevas LP, Ruppen I, Ximénez-Embún P, Domingo S, Gayarre J, Muñoz J, Silva JM, García MJ, Benítez J.

Oncotarget. 2014 Apr 30;5(8):2330-43.


Cullin4A and cullin4B are interchangeable for HIV Vpr and Vpx action through the CRL4 ubiquitin ligase complex.

Sharifi HJ, Furuya AK, Jellinger RM, Nekorchuk MD, de Noronha CM.

J Virol. 2014 Jun;88(12):6944-58. doi: 10.1128/JVI.00241-14. Epub 2014 Apr 9.


Lung tumourigenesis in a conditional Cul4A transgenic mouse model.

Yang YL, Hung MS, Wang Y, Ni J, Mao JH, Hsieh D, Au A, Kumar A, Quigley D, Fang LT, Yeh CC, Xu Z, Jablons DM, You L.

J Pathol. 2014 Jun;233(2):113-23. doi: 10.1002/path.4352.


CUL4A ubiquitin ligase: a promising drug target for cancer and other human diseases.

Sharma P, Nag A.

Open Biol. 2014 Feb 12;4:130217. doi: 10.1098/rsob.130217. Review.


CUL4A induces epithelial-mesenchymal transition and promotes cancer metastasis by regulating ZEB1 expression.

Wang Y, Wen M, Kwon Y, Xu Y, Liu Y, Zhang P, He X, Wang Q, Huang Y, Jen KY, LaBarge MA, You L, Kogan SC, Gray JW, Mao JH, Wei G.

Cancer Res. 2014 Jan 15;74(2):520-31. doi: 10.1158/0008-5472.CAN-13-2182. Epub 2013 Dec 4.

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