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Items: 6


Rational design of sulfonated A3 adenosine receptor-selective nucleosides as pharmacological tools to study chronic neuropathic pain.

Paoletta S, Tosh DK, Finley A, Gizewski ET, Moss SM, Gao ZG, Auchampach JA, Salvemini D, Jacobson KA.

J Med Chem. 2013 Jul 25;56(14):5949-63. doi: 10.1021/jm4007966. Epub 2013 Jul 3.


Truncated Nucleosides as A(3) Adenosine Receptor Ligands: Combined 2-Arylethynyl and Bicyclohexane Substitutions.

Tosh DK, Paoletta S, Phan K, Gao ZG, Jacobson KA.

ACS Med Chem Lett. 2012 Jul 12;3(7):596-601. Epub 2012 Jun 11.


Click modification in the N6 region of A3 adenosine receptor-selective carbocyclic nucleosides for dendrimeric tethering that preserves pharmacophore recognition.

Tosh DK, Phan K, Deflorian F, Wei Q, Yoo LS, Gao ZG, Jacobson KA.

Bioconjug Chem. 2012 Feb 15;23(2):232-47. doi: 10.1021/bc200526c. Epub 2012 Jan 11.


Polyamidoamine (PAMAM) dendrimer conjugate specifically activates the A3 adenosine receptor to improve post-ischemic/reperfusion function in isolated mouse hearts.

Wan TC, Tosh DK, Du L, Gizewski ET, Jacobson KA, Auchampach JA.

BMC Pharmacol. 2011 Oct 31;11:11. doi: 10.1186/1471-2210-11-11.


A role for the low-affinity A2B adenosine receptor in regulating superoxide generation by murine neutrophils.

van der Hoeven D, Wan TC, Gizewski ET, Kreckler LM, Maas JE, Van Orman J, Ravid K, Auchampach JA.

J Pharmacol Exp Ther. 2011 Sep;338(3):1004-12. doi: 10.1124/jpet.111.181792. Epub 2011 Jun 21.


Recent developments in adenosine receptor ligands and their potential as novel drugs.

Müller CE, Jacobson KA.

Biochim Biophys Acta. 2011 May;1808(5):1290-308. doi: 10.1016/j.bbamem.2010.12.017. Epub 2010 Dec 23. Review.

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