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JNK activation is essential for activation of MEK/ERK signaling in IL-1β-induced COX-2 expression in synovial fibroblasts.

Kitanaka T, Nakano R, Kitanaka N, Kimura T, Okabayashi K, Narita T, Sugiya H.

Sci Rep. 2017 Jan 5;7:39914. doi: 10.1038/srep39914.


MicroRNA-Mediated Down-Regulation of Apoptosis Signal-Regulating Kinase 1 (ASK1) Attenuates the Apoptosis of Human Mesenchymal Stem Cells (MSCs) Transplanted into Infarcted Heart.

Lee CY, Shin S, Lee J, Seo HH, Lim KH, Kim H, Choi JW, Kim SW, Lee S, Lim S, Hwang KC.

Int J Mol Sci. 2016 Oct 20;17(10). pii: E1752.


C-Jun N-terminal kinase signalling pathway in response to cisplatin.

Yan D, An G, Kuo MT.

J Cell Mol Med. 2016 Nov;20(11):2013-2019. doi: 10.1111/jcmm.12908. Review.


Efficacy of focal adhesion kinase inhibition in non-small cell lung cancer with oncogenically activated MAPK pathways.

Zhang H, Shao H, Golubovskaya VM, Chen H, Cance W, Adjei AA, Dy GK.

Br J Cancer. 2016 Jul 12;115(2):203-11. doi: 10.1038/bjc.2016.190.


In vitro and in vivo neuroprotective effects of cJun N-terminal kinase inhibitors on retinal ganglion cells.

Kim BJ, Silverman SM, Liu Y, Wordinger RJ, Pang IH, Clark AF.

Mol Neurodegener. 2016 Apr 21;11:30. doi: 10.1186/s13024-016-0093-4.


The novel JNK inhibitor AS602801 inhibits cancer stem cells in vitro and in vivo.

Okada M, Kuramoto K, Takeda H, Watarai H, Sakaki H, Seino S, Seino M, Suzuki S, Kitanaka C.

Oncotarget. 2016 May 10;7(19):27021-32. doi: 10.18632/oncotarget.8395.


The p21-activated kinase, PAK2, is important in the activation of numerous pancreatic acinar cell signaling cascades and in the onset of early pancreatitis events.

Nuche-Berenguer B, Ramos-Álvarez I, Jensen RT.

Biochim Biophys Acta. 2016 Jun;1862(6):1122-36. doi: 10.1016/j.bbadis.2016.02.008.


Autotetraploid cell line induced by SP600125 from crucian carp and its developmental potentiality.

Zhou Y, Wang M, Jiang M, Peng L, Wan C, Liu J, Liu W, Zhao R, Zhao X, Hu W, Liu S, Xiao Y.

Sci Rep. 2016 Feb 22;6:21814. doi: 10.1038/srep21814.


c-Jun N-terminal Kinase (JNK) Signaling as a Therapeutic Target for Alzheimer's Disease.

Yarza R, Vela S, Solas M, Ramirez MJ.

Front Pharmacol. 2016 Jan 12;6:321. doi: 10.3389/fphar.2015.00321. Review.


Islet Brain 1 Protects Insulin Producing Cells against Lipotoxicity.

Brajkovic S, Ferdaoussi M, Pawlowski V, Ezanno H, Plaisance V, Zmuda E, Hai T, Annicotte JS, Waeber G, Abderrahmani A.

J Diabetes Res. 2016;2016:9158562. doi: 10.1155/2016/9158562.


Mitogen-activated protein kinase signaling pathway and invasion and metastasis of gastric cancer.

Yang M, Huang CZ.

World J Gastroenterol. 2015 Nov 7;21(41):11673-9. doi: 10.3748/wjg.v21.i41.11673. Review.


Diphlorethohydroxycarmalol Suppresses Ultraviolet B-Induced Matrix Metalloproteinases via Inhibition of JNK and ERK Signaling in Human Keratinocytes.

Piao MJ, Susara Ruwan Kumara MH, Kim KC, Kang KA, Kang HK, Lee NH, Hyun JW.

Biomol Ther (Seoul). 2015 Nov;23(6):557-63. doi: 10.4062/biomolther.2015.054.


Drosophila Eye Model to Study Neuroprotective Role of CREB Binding Protein (CBP) in Alzheimer's Disease.

Cutler T, Sarkar A, Moran M, Steffensmeier A, Puli OR, Mancini G, Tare M, Gogia N, Singh A.

PLoS One. 2015 Sep 14;10(9):e0137691. doi: 10.1371/journal.pone.0137691.


Neutralization of osteopontin attenuates neutrophil migration in sepsis-induced acute lung injury.

Hirano Y, Aziz M, Yang WL, Wang Z, Zhou M, Ochani M, Khader A, Wang P.

Crit Care. 2015 Feb 26;19:53. doi: 10.1186/s13054-015-0782-3.


Anti-Inflammatory Effects and Joint Protection in Collagen-Induced Arthritis after Treatment with IQ-1S, a Selective c-Jun N-Terminal Kinase Inhibitor.

Schepetkin IA, Kirpotina LN, Hammaker D, Kochetkova I, Khlebnikov AI, Lyakhov SA, Firestein GS, Quinn MT.

J Pharmacol Exp Ther. 2015 Jun;353(3):505-16. doi: 10.1124/jpet.114.220251.


XG-102 administered to healthy male volunteers as a single intravenous infusion: a randomized, double-blind, placebo-controlled, dose-escalating study.

Deloche C, Lopez-Lazaro L, Mouz S, Perino J, Abadie C, Combette JM.

Pharmacol Res Perspect. 2014 Feb;2(1):e00020. doi: 10.1002/prp2.20.


Design and synthesis of highly potent and isoform selective JNK3 inhibitors: SAR studies on aminopyrazole derivatives.

Zheng K, Iqbal S, Hernandez P, Park H, LoGrasso PV, Feng Y.

J Med Chem. 2014 Dec 11;57(23):10013-30. doi: 10.1021/jm501256y.


Calcium/Ask1/MKK7/JNK2/c-Src signalling cascade mediates disruption of intestinal epithelial tight junctions by dextran sulfate sodium.

Samak G, Chaudhry KK, Gangwar R, Narayanan D, Jaggar JH, Rao R.

Biochem J. 2015 Feb 1;465(3):503-15. doi: 10.1042/BJ20140450.


Intercellular cooperation and competition in brain cancers: lessons from Drosophila and human studies.

Waghmare I, Roebke A, Minata M, Kango-Singh M, Nakano I.

Stem Cells Transl Med. 2014 Nov;3(11):1262-8. doi: 10.5966/sctm.2014-0086. Review.

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