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Items: 15


Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction.

Vincendeau M, Hadian K, Messias AC, Brenke JK, Halander J, Griesbach R, Greczmiel U, Bertossi A, Stehle R, Nagel D, Demski K, Velvarska H, Niessing D, Geerlof A, Sattler M, Krappmann D.

Sci Rep. 2016 Jan 7;6:18934. doi: 10.1038/srep18934.


Inherited and acquired immunodeficiencies underlying tuberculosis in childhood.

Boisson-Dupuis S, Bustamante J, El-Baghdadi J, Camcioglu Y, Parvaneh N, El Azbaoui S, Agader A, Hassani A, El Hafidi N, Mrani NA, Jouhadi Z, Ailal F, Najib J, Reisli I, Zamani A, Yosunkaya S, Gulle-Girit S, Yildiran A, Cipe FE, Torun SH, Metin A, Atikan BY, Hatipoglu N, Aydogmus C, Kilic SS, Dogu F, Karaca N, Aksu G, Kutukculer N, Keser-Emiroglu M, Somer A, Tanir G, Aytekin C, Adimi P, Mahdaviani SA, Mamishi S, Bousfiha A, Sanal O, Mansouri D, Casanova JL, Abel L.

Immunol Rev. 2015 Mar;264(1):103-20. doi: 10.1111/imr.12272. Review.


Mendelian susceptibility to mycobacterial disease: genetic, immunological, and clinical features of inborn errors of IFN-γ immunity.

Bustamante J, Boisson-Dupuis S, Abel L, Casanova JL.

Semin Immunol. 2014 Dec;26(6):454-70. doi: 10.1016/j.smim.2014.09.008. Review.


The IκB kinase complex in NF-κB regulation and beyond.

Hinz M, Scheidereit C.

EMBO Rep. 2014 Jan;15(1):46-61. doi: 10.1002/embr.201337983. Review.


Mutation of nonessential cysteines shows that the NF-κB essential modulator forms a constitutive noncovalent dimer that binds IκB kinase-β with high affinity.

Cote SM, Gilmore TD, Shaffer R, Weber U, Bollam R, Golden MS, Glover K, Herscovitch M, Ennis T, Allen KN, Whitty A.

Biochemistry. 2013 Dec 23;52(51):9141-54. doi: 10.1021/bi401368r.


Two-sided ubiquitin binding of NF-κB essential modulator (NEMO) zinc finger unveiled by a mutation associated with anhidrotic ectodermal dysplasia with immunodeficiency syndrome.

Ngadjeua F, Chiaravalli J, Traincard F, Raynal B, Fontan E, Agou F.

J Biol Chem. 2013 Nov 22;288(47):33722-37. doi: 10.1074/jbc.M113.483305.


Design, construction, and characterization of a second-generation DARP in library with reduced hydrophobicity.

Seeger MA, Zbinden R, Flütsch A, Gutte PG, Engeler S, Roschitzki-Voser H, Grütter MG.

Protein Sci. 2013 Sep;22(9):1239-57. doi: 10.1002/pro.2312.


The α-helical regions of KERP1 are important in Entamoeba histolytica adherence to human cells.

Perdomo D, Baron B, Rojo-Domínguez A, Raynal B, England P, Guillén N.

Sci Rep. 2013;3:1171. doi: 10.1038/srep01171.


Structural insights for engineering binding proteins based on non-antibody scaffolds.

Gilbreth RN, Koide S.

Curr Opin Struct Biol. 2012 Aug;22(4):413-20. doi: 10.1016/ Review.


Antibody fragments as tools in crystallography.

Griffin L, Lawson A.

Clin Exp Immunol. 2011 Sep;165(3):285-91. doi: 10.1111/j.1365-2249.2011.04427.x. Review.


New mechanism of X-linked anhidrotic ectodermal dysplasia with immunodeficiency: impairment of ubiquitin binding despite normal folding of NEMO protein.

Hubeau M, Ngadjeua F, Puel A, Israel L, Feinberg J, Chrabieh M, Belani K, Bodemer C, Fabre I, Plebani A, Boisson-Dupuis S, Picard C, Fischer A, Israel A, Abel L, Veron M, Casanova JL, Agou F, Bustamante J.

Blood. 2011 Jul 28;118(4):926-35. doi: 10.1182/blood-2010-10-315234.


NF-κB essential modulator (NEMO) interaction with linear and lys-63 ubiquitin chains contributes to NF-κB activation.

Hadian K, Griesbach RA, Dornauer S, Wanger TM, Nagel D, Metlitzky M, Beisker W, Schmidt-Supprian M, Krappmann D.

J Biol Chem. 2011 Jul 22;286(29):26107-17. doi: 10.1074/jbc.M111.233163.


Kaposi's sarcoma-associated herpesvirus vFLIP and human T cell lymphotropic virus type 1 Tax oncogenic proteins activate IkappaB kinase subunit gamma by different mechanisms independent of the physiological cytokine-induced pathways.

Shimizu A, Baratchian M, Takeuchi Y, Escors D, Macdonald D, Barrett T, Bagneris C, Collins M, Noursadeghi M.

J Virol. 2011 Jul;85(14):7444-8. doi: 10.1128/JVI.02337-10.


Nuclear initiated NF-κB signaling: NEMO and ATM take center stage.

Miyamoto S.

Cell Res. 2011 Jan;21(1):116-30. doi: 10.1038/cr.2010.179. Review.


NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain.

Laplantine E, Fontan E, Chiaravalli J, Lopez T, Lakisic G, Véron M, Agou F, Israël A.

EMBO J. 2009 Oct 7;28(19):2885-95. doi: 10.1038/emboj.2009.241.

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