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Items: 1 to 20 of 26


Destabilizing the autoinhibitory conformation of Zap70 induces up-regulation of inhibitory receptors and T cell unresponsiveness.

Hsu LY, Cheng DA, Chen Y, Liang HE, Weiss A.

J Exp Med. 2017 Mar 6;214(3):833-849. doi: 10.1084/jem.20161575. Epub 2017 Feb 3.


Phosphorylation of a Tyrosine Residue on Zap70 by Lck and Its Subsequent Binding via an SH2 Domain May Be a Key Gatekeeper of T Cell Receptor Signaling In Vivo.

Thill PA, Weiss A, Chakraborty AK.

Mol Cell Biol. 2016 Aug 26;36(18):2396-402. doi: 10.1128/MCB.00165-16. Print 2016 Sep 15.


Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice.

Sood S, Brownlie RJ, Garcia C, Cowan G, Salmond RJ, Sakaguchi S, Zamoyska R.

J Immunol. 2016 Jul 15;197(2):429-40. doi: 10.4049/jimmunol.1502656. Epub 2016 Jun 10.


T cell receptor signalling in the control of regulatory T cell differentiation and function.

Li MO, Rudensky AY.

Nat Rev Immunol. 2016 Apr;16(4):220-33. doi: 10.1038/nri.2016.26. Review.


Disrupted regulatory T cell homeostasis in inflammatory bowel diseases.

Pedros C, Duguet F, Saoudi A, Chabod M.

World J Gastroenterol. 2016 Jan 21;22(3):974-95. doi: 10.3748/wjg.v22.i3.974. Review.


Mechanisms of Microbe-Host Interaction in Crohn's Disease: Dysbiosis vs. Pathobiont Selection.

Buttó LF, Schaubeck M, Haller D.

Front Immunol. 2015 Nov 19;6:555. doi: 10.3389/fimmu.2015.00555. eCollection 2015. Review.


Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance.

O'Hagan KL, Choi J, Pryshchep O, Chernoff J, Phee H.

J Immunol. 2015 Aug 15;195(4):1564-77. doi: 10.4049/jimmunol.1500843. Epub 2015 Jul 8.


The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.

Goodfellow HS, Frushicheva MP, Ji Q, Cheng DA, Kadlecek TA, Cantor AJ, Kuriyan J, Chakraborty AK, Salomon A, Weiss A.

Sci Signal. 2015 May 19;8(377):ra49. doi: 10.1126/scisignal.2005596.


Regulatory T cells require TCR signaling for their suppressive function.

Schmidt AM, Lu W, Sindhava VJ, Huang Y, Burkhardt JK, Yang E, Riese MJ, Maltzman JS, Jordan MS, Kambayashi T.

J Immunol. 2015 May 1;194(9):4362-70. doi: 10.4049/jimmunol.1402384. Epub 2015 Mar 27.


Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease.

Ito Y, Hashimoto M, Hirota K, Ohkura N, Morikawa H, Nishikawa H, Tanaka A, Furu M, Ito H, Fujii T, Nomura T, Yamazaki S, Morita A, Vignali DA, Kappler JW, Matsuda S, Mimori T, Sakaguchi N, Sakaguchi S.

Science. 2014 Oct 17;346(6207):363-8. doi: 10.1126/science.1259077.


Insights into the initiation of TCR signaling.

Chakraborty AK, Weiss A.

Nat Immunol. 2014 Sep;15(9):798-807. doi: 10.1038/ni.2940. Review.


Zap70 is essential for long-term survival of naive CD8 T cells.

Schim van der Loeff I, Hsu LY, Saini M, Weiss A, Seddon B.

J Immunol. 2014 Sep 15;193(6):2873-80. doi: 10.4049/jimmunol.1400858. Epub 2014 Aug 4.


Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development.

Au-Yeung BB, Melichar HJ, Ross JO, Cheng DA, Zikherman J, Shokat KM, Robey EA, Weiss A.

Nat Immunol. 2014 Jul;15(7):687-94. doi: 10.1038/ni.2918. Epub 2014 Jun 8. Erratum in: Nat Immunol. 2015 Feb;16(2):214.


A ZAP-70 kinase domain variant prevents thymocyte-positive selection despite signalling CD69 induction.

Siggs OM, Yates AL, Schlenner S, Liston A, Lesage S, Goodnow CC.

Immunology. 2014 Apr;141(4):587-95. doi: 10.1111/imm.12220.


A novel Zap70 mutation with reduced protein stability demonstrates the rate-limiting threshold for Zap70 in T-cell receptor signalling.

Cauwe B, Tian L, Franckaert D, Pierson W, Staats KA, Schlenner SM, Liston A.

Immunology. 2014 Mar;141(3):377-87. doi: 10.1111/imm.12199.


The janus head of T cell aging - autoimmunity and immunodeficiency.

Goronzy JJ, Li G, Yang Z, Weyand CM.

Front Immunol. 2013 Jun 4;4:131. doi: 10.3389/fimmu.2013.00131. eCollection 2013.


Structural basis for activation of ZAP-70 by phosphorylation of the SH2-kinase linker.

Yan Q, Barros T, Visperas PR, Deindl S, Kadlecek TA, Weiss A, Kuriyan J.

Mol Cell Biol. 2013 Jun;33(11):2188-201. doi: 10.1128/MCB.01637-12. Epub 2013 Mar 25.


Reduced TCR signaling potential impairs negative selection but does not result in autoimmune disease.

Hwang S, Song KD, Lesourne R, Lee J, Pinkhasov J, Li L, El-Khoury D, Love PE.

J Exp Med. 2012 Sep 24;209(10):1781-95. Epub 2012 Sep 3.


Altered BCR signalling quality predisposes to autoimmune disease and a pre-diabetic state.

Königsberger S, Prodöhl J, Stegner D, Weis V, Andreas M, Stehling M, Schumacher T, Böhmer R, Thielmann I, van Eeuwijk JM, Nieswandt B, Kiefer F.

EMBO J. 2012 Aug 1;31(15):3363-74. doi: 10.1038/emboj.2012.169. Epub 2012 Jun 22.


T cell receptor signaling that regulates the development of intrathymic natural regulatory T cells.

Song KD, Hwang S, Yun CH.

Immune Netw. 2011 Dec;11(6):336-41. doi: 10.4110/in.2011.11.6.336. Epub 2011 Dec 31.

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