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Items: 14


Hepatic cytochromes P450: structural degrons and barcodes, posttranslational modifications and cellular adapters in the ERAD-endgame.

Kim SM, Wang Y, Nabavi N, Liu Y, Correia MA.

Drug Metab Rev. 2016 Aug;48(3):405-33. doi: 10.1080/03602532.2016.1195403. Epub 2016 Jun 20.


Endoplasmic Reticulum-associated Degradation of Pca1p, a Polytopic Protein, via Interaction with the Proteasome at the Membrane.

Smith N, Adle DJ, Zhao M, Qin X, Kim H, Lee J.

J Biol Chem. 2016 Jul 15;291(29):15082-92. doi: 10.1074/jbc.M116.726265. Epub 2016 May 12.


Unsaturated Fatty Acids Stimulate Tumor Growth through Stabilization of β-Catenin.

Kim H, Rodriguez-Navas C, Kollipara RK, Kapur P, Pedrosa I, Brugarolas J, Kittler R, Ye J.

Cell Rep. 2015 Oct 20;13(3):496-503. doi: 10.1016/j.celrep.2015.09.010. Epub 2015 Oct 8.


Scap is required for sterol synthesis and crypt growth in intestinal mucosa.

McFarlane MR, Cantoria MJ, Linden AG, January BA, Liang G, Engelking LJ.

J Lipid Res. 2015 Aug;56(8):1560-71. doi: 10.1194/jlr.M059709. Epub 2015 Apr 20.


Cytokine profiling in patients with VCP-associated disease.

Dec E, Rana P, Katheria V, Dec R, Khare M, Nalbandian A, Leu SY, Radom-Aizik S, Llewellyn K, BenMohamed L, Zaldivar F, Kimonis V.

Clin Transl Sci. 2014 Feb;7(1):29-32. doi: 10.1111/cts.12117. Epub 2013 Oct 3.


Point mutation in luminal loop 7 of Scap protein blocks interaction with loop 1 and abolishes movement to Golgi.

Zhang Y, Motamed M, Seemann J, Brown MS, Goldstein JL.

J Biol Chem. 2013 May 17;288(20):14059-67. doi: 10.1074/jbc.M113.469528. Epub 2013 Apr 5.


Regulation of cholesterol and fatty acid synthesis.

Ye J, DeBose-Boyd RA.

Cold Spring Harb Perspect Biol. 2011 Jul 1;3(7). pii: a004754. doi: 10.1101/cshperspect.a004754. Review.


Enzymatic blockade of the ubiquitin-proteasome pathway.

Ernst R, Claessen JH, Mueller B, Sanyal S, Spooner E, van der Veen AG, Kirak O, Schlieker CD, Weihofen WA, Ploegh HL.

PLoS Biol. 2011 Mar;8(3):e1000605. doi: 10.1371/journal.pbio.1000605. Epub 2011 Mar 29.


Identification of luminal Loop 1 of Scap protein as the sterol sensor that maintains cholesterol homeostasis.

Motamed M, Zhang Y, Wang ML, Seemann J, Kwon HJ, Goldstein JL, Brown MS.

J Biol Chem. 2011 May 20;286(20):18002-12. doi: 10.1074/jbc.M111.238311. Epub 2011 Mar 24.


Identification of Ubxd8 protein as a sensor for unsaturated fatty acids and regulator of triglyceride synthesis.

Lee JN, Kim H, Yao H, Chen Y, Weng K, Ye J.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21424-9. doi: 10.1073/pnas.1011859107. Epub 2010 Nov 29.


Liver cytochrome P450 3A endoplasmic reticulum-associated degradation: a major role for the p97 AAA ATPase in cytochrome P450 3A extraction into the cytosol.

Acharya P, Liao M, Engel JC, Correia MA.

J Biol Chem. 2011 Feb 4;286(5):3815-28. doi: 10.1074/jbc.M110.186981. Epub 2010 Nov 24.


Cholesterol, the central lipid of mammalian cells.

Maxfield FR, van Meer G.

Curr Opin Cell Biol. 2010 Aug;22(4):422-9. doi: 10.1016/ Epub 2010 Jun 2. Review.


Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase.

Jo Y, Debose-Boyd RA.

Crit Rev Biochem Mol Biol. 2010 Jun;45(3):185-98. doi: 10.3109/10409238.2010.485605. Review.

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