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Brd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesis.

Lee JE, Park YK, Park S, Jang Y, Waring N, Dey A, Ozato K, Lai B, Peng W, Ge K.

Nat Commun. 2017 Dec 20;8(1):2217. doi: 10.1038/s41467-017-02403-5.


Targeting bromodomain and extraterminal proteins in breast cancer.

Sahni JM, Keri RA.

Pharmacol Res. 2018 Mar;129:156-176. doi: 10.1016/j.phrs.2017.11.015. Epub 2017 Nov 16. Review.


Combination of EZH2 inhibitor and BET inhibitor for treatment of diffuse intrinsic pontine glioma.

Zhang Y, Dong W, Zhu J, Wang L, Wu X, Shan H.

Cell Biosci. 2017 Oct 30;7:56. doi: 10.1186/s13578-017-0184-0. eCollection 2017.


Epigenetic Alterations in Human Papillomavirus-Associated Cancers.

Soto D, Song C, McLaughlin-Drubin ME.

Viruses. 2017 Sep 1;9(9). pii: E248. doi: 10.3390/v9090248. Review.


BRD4 inhibitors block telomere elongation.

Wang S, Pike AM, Lee SS, Strong MA, Connelly CJ, Greider CW.

Nucleic Acids Res. 2017 Aug 21;45(14):8403-8410. doi: 10.1093/nar/gkx561.


An iridium(iii)-based irreversible protein-protein interaction inhibitor of BRD4 as a potent anticancer agent.

Zhong HJ, Lu L, Leung KH, Wong CCL, Peng C, Yan SC, Ma DL, Cai Z, David Wang HM, Leung CH.

Chem Sci. 2015 Oct 1;6(10):5400-5408. doi: 10.1039/c5sc02321a. Epub 2015 Jul 30.


BRD3 and BRD4 BET Bromodomain Proteins Differentially Regulate Skeletal Myogenesis.

Roberts TC, Etxaniz U, Dall'Agnese A, Wu SY, Chiang CM, Brennan PE, Wood MJA, Puri PL.

Sci Rep. 2017 Jul 21;7(1):6153. doi: 10.1038/s41598-017-06483-7.


Ubenimex enhances Brd4 inhibition by suppressing HEXIM1 autophagic degradation and suppressing the Akt pathway in glioma cells.

Han L, Zhao Q, Liang X, Wang X, Zhang Z, Ma Z, Zhao M, Wang A, Liu S.

Oncotarget. 2017 Jul 11;8(28):45643-45655. doi: 10.18632/oncotarget.17314.


Combined AURKA and H3K9 Methyltransferase Targeting Inhibits Cell Growth By Inducing Mitotic Catastrophe.

Mathison A, Salmonson A, Missfeldt M, Bintz J, Williams M, Kossak S, Nair A, de Assuncao TM, Christensen T, Buttar N, Iovanna J, Huebert R, Lomberk G.

Mol Cancer Res. 2017 Aug;15(8):984-997. doi: 10.1158/1541-7786.MCR-17-0063. Epub 2017 Apr 25.


BET proteins are a key component of immunoglobulin gene expression.

Shim JM, Lee JS, Russell KE, Wiegman CH, Barnes PJ, Fear D, Adcock IM, Durham AL.

Epigenomics. 2017 Apr;9(4):393-406. doi: 10.2217/epi-2016-0147. Epub 2017 Mar 21.


Inhibitors of BRD4 Protein from a Marine-Derived Fungus Alternaria sp. NH-F6.

Ding H, Zhang D, Zhou B, Ma Z.

Mar Drugs. 2017 Mar 16;15(3). pii: E76. doi: 10.3390/md15030076.


Epigenetic characteristics of the mitotic chromosome in 1D and 3D.

Oomen ME, Dekker J.

Crit Rev Biochem Mol Biol. 2017 Apr;52(2):185-204. doi: 10.1080/10409238.2017.1287160. Epub 2017 Feb 15. Review.


Cdc15 Phosphorylates the C-terminal Domain of RNA Polymerase II for Transcription during Mitosis.

Singh AK, Rastogi S, Shukla H, Asalam M, Rath SK, Akhtar MS.

J Biol Chem. 2017 Mar 31;292(13):5507-5518. doi: 10.1074/jbc.M116.761056. Epub 2017 Feb 15.


Drug Discovery Targeting Bromodomain-Containing Protein 4.

Liu Z, Wang P, Chen H, Wold EA, Tian B, Brasier AR, Zhou J.

J Med Chem. 2017 Jun 8;60(11):4533-4558. doi: 10.1021/acs.jmedchem.6b01761. Epub 2017 Mar 2. Review.


The bromodomain inhibitor JQ1 triggers growth arrest and apoptosis in testicular germ cell tumours in vitro and in vivo.

Jostes S, Nettersheim D, Fellermeyer M, Schneider S, Hafezi F, Honecker F, Schumacher V, Geyer M, Kristiansen G, Schorle H.

J Cell Mol Med. 2017 Jul;21(7):1300-1314. doi: 10.1111/jcmm.13059. Epub 2016 Dec 27.


A role for mitotic bookmarking of SOX2 in pluripotency and differentiation.

Deluz C, Friman ET, Strebinger D, Benke A, Raccaud M, Callegari A, Leleu M, Manley S, Suter DM.

Genes Dev. 2016 Nov 15;30(22):2538-2550. Epub 2016 Dec 5.


Chromatin proteins and RNA are associated with DNA during all phases of mitosis.

L Black K, Petruk S, Fenstermaker TK, Hodgson JW, Caplan JL, Brock HW, Mazo A.

Cell Discov. 2016 Oct 25;2:16038. eCollection 2016.


Erythropoiesis provides a BRD's eye view of BET protein function.

Stonestrom AJ, Hsu SC, Werner MT, Blobel GA.

Drug Discov Today Technol. 2016 Mar;19:23-28. doi: 10.1016/j.ddtec.2016.05.004. Epub 2016 Jul 20. Review.

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