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Items: 18


Compounds identified by virtual docking to a tetrameric EGFR extracellular domain can modulate Grb2 internalization.

Ramirez UD, Nikonova AS, Liu H, Pecherskaya A, Lawrence SH, Serebriiskii IG, Zhou Y, Robinson MK, Einarson MB, Golemis EA, Jaffe EK.

BMC Cancer. 2015 May 28;15:436. doi: 10.1186/s12885-015-1415-6.


A framework for application of metabolic modeling in yeast to predict the effects of nsSNV in human orthologs.

Dingerdissen H, Weaver DS, Karp PD, Pan Y, Simonyan V, Mazumder R.

Biol Direct. 2014 Jun 3;9:9. doi: 10.1186/1745-6150-9-9.


wALADin benzimidazoles differentially modulate the function of porphobilinogen synthase orthologs.

Lentz CS, Halls VS, Hannam JS, Strassel S, Lawrence SH, Jaffe EK, Famulok M, Hoerauf A, Pfarr KM.

J Med Chem. 2014 Mar 27;57(6):2498-510. doi: 10.1021/jm401785n. Epub 2014 Feb 25.


Development of a fluorescent monoclonal antibody-based assay to measure the allosteric effects of synthetic peptides on self-oligomerization of AGR2 protein.

Gray TA, Murray E, Nowicki MW, Remnant L, Scherl A, Muller P, Vojtesek B, Hupp TR.

Protein Sci. 2013 Sep;22(9):1266-78. doi: 10.1002/pro.2299. Epub 2013 Jul 25.


A new model for allosteric regulation of phenylalanine hydroxylase: implications for disease and therapeutics.

Jaffe EK, Stith L, Lawrence SH, Andrake M, Dunbrack RL Jr.

Arch Biochem Biophys. 2013 Feb 15;530(2):73-82. doi: 10.1016/ Epub 2013 Jan 11.


Fine-tuning multiprotein complexes using small molecules.

Thompson AD, Dugan A, Gestwicki JE, Mapp AK.

ACS Chem Biol. 2012 Aug 17;7(8):1311-20. doi: 10.1021/cb300255p. Epub 2012 Jul 23. Review.


Dynamic dissociating homo-oligomers and the control of protein function.

Selwood T, Jaffe EK.

Arch Biochem Biophys. 2012 Mar 15;519(2):131-43. doi: 10.1016/ Epub 2011 Dec 13. Review.


The morpheein model of allostery: evaluating proteins as potential morpheeins.

Jaffe EK, Lawrence SH.

Methods Mol Biol. 2012;796:217-31. doi: 10.1007/978-1-61779-334-9_12.


Allostery and the dynamic oligomerization of porphobilinogen synthase.

Jaffe EK, Lawrence SH.

Arch Biochem Biophys. 2012 Mar 15;519(2):144-53. doi: 10.1016/ Epub 2011 Oct 19. Review.


Pseudomonas aeruginosa porphobilinogen synthase assembly state regulators: hit discovery and initial SAR studies.

Reitz AB, Ramirez UD, Stith L, Du Y, Smith GR, Jaffe EK.

ARKIVOC. 2010 Jun;2010:175-188.


Diverse clinical compounds alter the quaternary structure and inhibit the activity of an essential enzyme.

Lawrence SH, Selwood T, Jaffe EK.

ChemMedChem. 2011 Jun 6;6(6):1067-73. doi: 10.1002/cmdc.201100009. Epub 2011 Apr 19.


Crystal structure of Toxoplasma gondii porphobilinogen synthase: insights on octameric structure and porphobilinogen formation.

Jaffe EK, Shanmugam D, Gardberg A, Dieterich S, Sankaran B, Stewart LJ, Myler PJ, Roos DS.

J Biol Chem. 2011 Apr 29;286(17):15298-307. doi: 10.1074/jbc.M111.226225. Epub 2011 Mar 7.


Docking to large allosteric binding sites on protein surfaces.

Ramirez UD, Myachina F, Stith L, Jaffe EK.

Adv Exp Med Biol. 2010;680:481-8. doi: 10.1007/978-1-4419-5913-3_54.


Cloning, expression, purification, crystallization and preliminary crystallographic analysis of 5-aminolaevulinic acid dehydratase from Bacillus subtilis.

Lu Q, Ma J, Rong H, Fan J, Yuan Y, Li K, Gao Y, Zhang X, Teng M, Niu L.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Sep 1;66(Pt 9):1053-5. doi: 10.1107/S1744309110027582. Epub 2010 Aug 26.


Plastid-associated porphobilinogen synthase from Toxoplasma gondii: kinetic and structural properties validate therapeutic potential.

Shanmugam D, Wu B, Ramirez U, Jaffe EK, Roos DS.

J Biol Chem. 2010 Jul 16;285(29):22122-31. doi: 10.1074/jbc.M110.107243. Epub 2010 May 4.

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