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Items: 12


A Simple Combinatorial Codon Mutagenesis Method for Targeted Protein Engineering.

Belsare KD, Andorfer MC, Cardenas FS, Chael JR, Park HJ, Lewis JC.

ACS Synth Biol. 2017 Mar 17;6(3):416-420. doi: 10.1021/acssynbio.6b00297. Epub 2017 Jan 4.


Directed Evolution of RebH for Catalyst-Controlled Halogenation of Indole C-H Bonds.

Andorfer MC, Park HJ, Vergara-Coll J, Lewis JC.

Chem Sci. 2016 Jun 1;7(6):3720-3729. Epub 2016 Feb 19.


Late-Stage Diversification of Biologically Active Molecules via Chemoenzymatic C-H Functionalization.

Durak LJ, Payne JT, Lewis JC.

ACS Catal. 2016 Mar 4;6(3):1451-1454. Epub 2016 Jan 25.


Use of chemical auxiliaries to control p450 enzymes for predictable oxidations at unactivated C-h bonds of substrates.

Auclair K, Polic V.

Adv Exp Med Biol. 2015;851:209-28. doi: 10.1007/978-3-319-16009-2_8. Review.


Controlling substrate specificity and product regio- and stereo-selectivities of P450 enzymes without mutagenesis.

Polic V, Auclair K.

Bioorg Med Chem. 2014 Oct 15;22(20):5547-54. doi: 10.1016/j.bmc.2014.06.034. Epub 2014 Jun 25. Review.


Metalloenzyme design and engineering through strategic modifications of native protein scaffolds.

Petrik ID, Liu J, Lu Y.

Curr Opin Chem Biol. 2014 Apr;19:67-75. doi: 10.1016/j.cbpa.2014.01.006. Epub 2014 Feb 8. Review.


Constructing de novo biosynthetic pathways for chemical synthesis inside living cells.

Weeks AM, Chang MC.

Biochemistry. 2011 Jun 21;50(24):5404-18. doi: 10.1021/bi200416g. Epub 2011 May 26. Review.


Cytochrome P450: taming a wild type enzyme.

Jung ST, Lauchli R, Arnold FH.

Curr Opin Biotechnol. 2011 Dec;22(6):809-17. doi: 10.1016/j.copbio.2011.02.008. Epub 2011 Mar 14. Review.


Combinatorial alanine substitution enables rapid optimization of cytochrome P450BM3 for selective hydroxylation of large substrates.

Lewis JC, Mantovani SM, Fu Y, Snow CD, Komor RS, Wong CH, Arnold FH.

Chembiochem. 2010 Dec 10;11(18):2502-5. doi: 10.1002/cbic.201000565. No abstract available.


Enzymatic functionalization of carbon-hydrogen bonds.

Lewis JC, Coelho PS, Arnold FH.

Chem Soc Rev. 2011 Apr;40(4):2003-21. doi: 10.1039/c0cs00067a. Epub 2010 Nov 15. Review.


Biology by design: from top to bottom and back.

Fritz BR, Timmerman LE, Daringer NM, Leonard JN, Jewett MC.

J Biomed Biotechnol. 2010;2010:232016. doi: 10.1155/2010/232016. Epub 2010 Nov 2. Review.


Structural evidence for enhancement of sequential vitamin D3 hydroxylation activities by directed evolution of cytochrome P450 vitamin D3 hydroxylase.

Yasutake Y, Fujii Y, Nishioka T, Cheon WK, Arisawa A, Tamura T.

J Biol Chem. 2010 Oct 8;285(41):31193-201. doi: 10.1074/jbc.M110.147009. Epub 2010 Jul 27.

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