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Items: 1 to 20 of 29


Non-degradative Ubiquitination of Protein Kinases.

Ball KA, Johnson JR, Lewinski MK, Guatelli J, Verschueren E, Krogan NJ, Jacobson MP.

PLoS Comput Biol. 2016 Jun 2;12(6):e1004898. doi: 10.1371/journal.pcbi.1004898.


Chemical Protein Ubiquitylation with Preservation of the Native Cysteine Residues.

Yang K, Li G, Gong P, Gui W, Yuan L, Zhuang Z.

Chembiochem. 2016 Jun 2;17(11):995-8. doi: 10.1002/cbic.201600042.


Chemical Synthesis of Phosphorylated Histone H2A at Tyr57 Reveals Insight into the Inhibition Mode of the SAGA Deubiquitinating Module.

Jbara M, Maity SK, Morgan M, Wolberger C, Brik A.

Angew Chem Int Ed Engl. 2016 Apr 11;55(16):4972-6. doi: 10.1002/anie.201600638.


Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation.

Zhou L, Holt MT, Ohashi N, Zhao A, Müller MM, Wang B, Muir TW.

Nat Commun. 2016 Feb 2;7:10589. doi: 10.1038/ncomms10589.


Identification of a functional hotspot on ubiquitin required for stimulation of methyltransferase activity on chromatin.

Holt MT, David Y, Pollock S, Tang Z, Jeon J, Kim J, Roeder RG, Muir TW.

Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10365-70. doi: 10.1073/pnas.1504483112.


Dot1 histone methyltransferases share a distributive mechanism but have highly diverged catalytic properties.

Stulemeijer IJ, De Vos D, van Harten K, Joshi OK, Blomberg O, van Welsem T, Terweij M, Vlaming H, de Graaf EL, Altelaar AF, Bakker BM, van Leeuwen F.

Sci Rep. 2015 May 12;5:9824. doi: 10.1038/srep09824.


Chemical tagging and customizing of cellular chromatin states using ultrafast trans-splicing inteins.

David Y, Vila-Perelló M, Verma S, Muir TW.

Nat Chem. 2015 May;7(5):394-402. doi: 10.1038/nchem.2224.


Chemical and biological tools for the preparation of modified histone proteins.

Howard CJ, Yu RR, Gardner ML, Shimko JC, Ottesen JJ.

Top Curr Chem. 2015;363:193-226. doi: 10.1007/128_2015_629.


Application of the protein semisynthesis strategy to the generation of modified chromatin.

Holt M, Muir T.

Annu Rev Biochem. 2015;84:265-90. doi: 10.1146/annurev-biochem-060614-034429. Review.


Structure-guided DOT1L probe optimization by label-free ligand displacement.

Yi JS, Federation AJ, Qi J, Dhe-Paganon S, Hadler M, Xu X, St Pierre R, Varca AC, Wu L, Marineau JJ, Smith WB, Souza A, Chory EJ, Armstrong SA, Bradner JE.

ACS Chem Biol. 2015 Mar 20;10(3):667-74. doi: 10.1021/cb500796d.


Histones: at the crossroads of peptide and protein chemistry.

Müller MM, Muir TW.

Chem Rev. 2015 Mar 25;115(6):2296-349. doi: 10.1021/cr5003529. Review. No abstract available.


Synthesis of non-linear protein dimers through a genetically encoded Thiol-ene reaction.

Torres-Kolbus J, Chou C, Liu J, Deiters A.

PLoS One. 2014 Sep 2;9(9):e105467. doi: 10.1371/journal.pone.0105467.


Accelerated chromatin biochemistry using DNA-barcoded nucleosome libraries.

Nguyen UT, Bittova L, Müller MM, Fierz B, David Y, Houck-Loomis B, Feng V, Dann GP, Muir TW.

Nat Methods. 2014 Aug;11(8):834-40. doi: 10.1038/nmeth.3022.


The challenge of producing ubiquitinated proteins for structural studies.

Faggiano S, Pastore A.

Cells. 2014 Jun 12;3(2):639-56. doi: 10.3390/cells3020639.


Modifying the vicinity of the isopeptide bond to reveal differential behavior of ubiquitin chains with interacting proteins: organic chemistry applied to synthetic proteins.

Haj-Yahya N, Haj-Yahya M, Castañeda CA, Spasser L, Hemantha HP, Jbara M, Penner M, Ciechanover A, Fushman D, Brik A.

Angew Chem Int Ed Engl. 2013 Oct 11;52(42):11149-53. doi: 10.1002/anie.201306118.


Targeted drug discovery for pediatric leukemia.

Napper AD, Watson VG.

Front Oncol. 2013 Jul 8;3:170. doi: 10.3389/fonc.2013.00170.


The n-SET domain of Set1 regulates H2B ubiquitylation-dependent H3K4 methylation.

Kim J, Kim JA, McGinty RK, Nguyen UT, Muir TW, Allis CD, Roeder RG.

Mol Cell. 2013 Mar 28;49(6):1121-33. doi: 10.1016/j.molcel.2013.01.034.


Stability of nucleosomes containing homogenously ubiquitylated H2A and H2B prepared using semisynthesis.

Fierz B, Kilic S, Hieb AR, Luger K, Muir TW.

J Am Chem Soc. 2012 Dec 5;134(48):19548-51. doi: 10.1021/ja308908p.


Histone monoubiquitylation position determines specificity and direction of enzymatic cross-talk with histone methyltransferases Dot1L and PRC2.

Whitcomb SJ, Fierz B, McGinty RK, Holt M, Ito T, Muir TW, Allis CD.

J Biol Chem. 2012 Jul 6;287(28):23718-25. doi: 10.1074/jbc.M112.361824.


Chromatin as an expansive canvas for chemical biology.

Fierz B, Muir TW.

Nat Chem Biol. 2012 Apr 17;8(5):417-27. doi: 10.1038/nchembio.938. Review.

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