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Items: 1 to 20 of 22


Specialized interfaces of Smc5/6 control hinge stability and DNA association.

Alt A, Dang HQ, Wells OS, Polo LM, Smith MA, McGregor GA, Welte T, Lehmann AR, Pearl LH, Murray JM, Oliver AW.

Nat Commun. 2017 Jan 30;8:14011. doi: 10.1038/ncomms14011.


Multi-BRCT scaffolds use distinct strategies to support genome maintenance.

Wan B, Hang LE, Zhao X.

Cell Cycle. 2016 Oct;15(19):2561-2570. Epub 2016 Aug 11.


Functions of Ubiquitin and SUMO in DNA Replication and Replication Stress.

García-Rodríguez N, Wong RP, Ulrich HD.

Front Genet. 2016 May 13;7:87. doi: 10.3389/fgene.2016.00087. eCollection 2016. Review.


Non-Smc element 5 (Nse5) of the Smc5/6 complex interacts with SUMO pathway components.

Bustard DE, Ball LG, Cobb JA.

Biol Open. 2016 Jun 15;5(6):777-85. doi: 10.1242/bio.018440.


Cross-Talk between Carbon Metabolism and the DNA Damage Response in S. cerevisiae.

Simpson-Lavy KJ, Bronstein A, Kupiec M, Johnston M.

Cell Rep. 2015 Sep 22;12(11):1865-75. doi: 10.1016/j.celrep.2015.08.025. Epub 2015 Sep 3.


Protein-Protein Interactions Mediated by Helical Tertiary Structure Motifs.

Watkins AM, Wuo MG, Arora PS.

J Am Chem Soc. 2015 Sep 16;137(36):11622-30. doi: 10.1021/jacs.5b05527. Epub 2015 Sep 4.


ATPase-dependent control of the Mms21 SUMO ligase during DNA repair.

Bermúdez-López M, Pociño-Merino I, Sánchez H, Bueno A, Guasch C, Almedawar S, Bru-Virgili S, Garí E, Wyman C, Reverter D, Colomina N, Torres-Rosell J.

PLoS Biol. 2015 Mar 12;13(3):e1002089. doi: 10.1371/journal.pbio.1002089. eCollection 2015 Mar.


Restriction of replication fork regression activities by a conserved SMC complex.

Xue X, Choi K, Bonner J, Chiba T, Kwon Y, Xu Y, Sanchez H, Wyman C, Niu H, Zhao X, Sung P.

Mol Cell. 2014 Nov 6;56(3):436-45. doi: 10.1016/j.molcel.2014.09.013. Epub 2014 Oct 16.


Hypomorphism in human NSMCE2 linked to primordial dwarfism and insulin resistance.

Payne F, Colnaghi R, Rocha N, Seth A, Harris J, Carpenter G, Bottomley WE, Wheeler E, Wong S, Saudek V, Savage D, O'Rahilly S, Carel JC, Barroso I, O'Driscoll M, Semple R.

J Clin Invest. 2014 Sep;124(9):4028-38. doi: 10.1172/JCI73264. Epub 2014 Aug 8.


Smc5/6-Mms21 prevents and eliminates inappropriate recombination intermediates in meiosis.

Xaver M, Huang L, Chen D, Klein F.

PLoS Genet. 2013;9(12):e1004067. doi: 10.1371/journal.pgen.1004067. Epub 2013 Dec 26.


SUMOylation regulates the SNF1 protein kinase.

Simpson-Lavy KJ, Johnston M.

Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17432-7. doi: 10.1073/pnas.1304839110. Epub 2013 Oct 9.


Distinct SUMO ligases cooperate with Esc2 and Slx5 to suppress duplication-mediated genome rearrangements.

Albuquerque CP, Wang G, Lee NS, Kolodner RD, Putnam CD, Zhou H.

PLoS Genet. 2013;9(8):e1003670. doi: 10.1371/journal.pgen.1003670. Epub 2013 Aug 1. Erratum in: PLoS Genet. 2016 Aug;12(8):e1006302.


AtMMS21, an SMC5/6 complex subunit, is involved in stem cell niche maintenance and DNA damage responses in Arabidopsis roots.

Xu P, Yuan D, Liu M, Li C, Liu Y, Zhang S, Yao N, Yang C.

Plant Physiol. 2013 Apr;161(4):1755-68. doi: 10.1104/pp.112.208942. Epub 2013 Feb 20.


MMS21/HPY2 and SIZ1, two Arabidopsis SUMO E3 ligases, have distinct functions in development.

Ishida T, Yoshimura M, Miura K, Sugimoto K.

PLoS One. 2012;7(10):e46897. doi: 10.1371/journal.pone.0046897. Epub 2012 Oct 8.


Dual roles of the SUMO-interacting motif in the regulation of Srs2 sumoylation.

Kolesar P, Sarangi P, Altmannova V, Zhao X, Krejci L.

Nucleic Acids Res. 2012 Sep;40(16):7831-43. doi: 10.1093/nar/gks484. Epub 2012 Jun 16.


During replication stress, non-SMC element 5 (NSE5) is required for Smc5/6 protein complex functionality at stalled forks.

Bustard DE, Menolfi D, Jeppsson K, Ball LG, Dewey SC, Shirahige K, Sjögren C, Branzei D, Cobb JA.

J Biol Chem. 2012 Mar 30;287(14):11374-83. doi: 10.1074/jbc.M111.336263. Epub 2012 Feb 2.


Nse1-dependent recruitment of Smc5/6 to lesion-containing loci contributes to the repair defects of mutant complexes.

Tapia-Alveal C, O'Connell MJ.

Mol Biol Cell. 2011 Dec;22(23):4669-82. doi: 10.1091/mbc.E11-03-0272. Epub 2011 Oct 5.


SUMOylation regulates telomere length homeostasis by targeting Cdc13.

Hang LE, Liu X, Cheung I, Yang Y, Zhao X.

Nat Struct Mol Biol. 2011 Jul 10;18(8):920-6. doi: 10.1038/nsmb.2100.


Interactions between the Nse3 and Nse4 components of the SMC5-6 complex identify evolutionarily conserved interactions between MAGE and EID Families.

Hudson JJ, Bednarova K, Kozakova L, Liao C, Guerineau M, Colnaghi R, Vidot S, Marek J, Bathula SR, Lehmann AR, Palecek J.

PLoS One. 2011 Feb 25;6(2):e17270. doi: 10.1371/journal.pone.0017270.

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