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Microglia amplify inflammatory activation of astrocytes in manganese neurotoxicity.

Kirkley KS, Popichak KA, Afzali MF, Legare ME, Tjalkens RB.

J Neuroinflammation. 2017 May 5;14(1):99. doi: 10.1186/s12974-017-0871-0.


Deficiency in the manganese efflux transporter SLC30A10 induces severe hypothyroidism in mice.

Hutchens S, Liu C, Jursa T, Shawlot W, Chaffee BK, Yin W, Gore AC, Aschner M, Smith DR, Mukhopadhyay S.

J Biol Chem. 2017 Jun 9;292(23):9760-9773. doi: 10.1074/jbc.M117.783605. Epub 2017 May 1.


Endogenous Two-Photon Excited Fluorescence Imaging Characterizes Neuron and Astrocyte Metabolic Responses to Manganese Toxicity.

Stuntz E, Gong Y, Sood D, Liaudanskaya V, Pouli D, Quinn KP, Alonzo C, Liu Z, Kaplan DL, Georgakoudi I.

Sci Rep. 2017 Apr 21;7(1):1041. doi: 10.1038/s41598-017-01015-9.


Redox dynamics of manganese as a mitochondrial life-death switch.

Smith MR, Fernandes J, Go YM, Jones DP.

Biochem Biophys Res Commun. 2017 Jan 15;482(3):388-398. doi: 10.1016/j.bbrc.2016.10.126. Epub 2017 Feb 3. Review.


Protection against Shiga Toxins.

Kavaliauskiene S, Dyve Lingelem AB, Skotland T, Sandvig K.

Toxins (Basel). 2017 Feb 3;9(2). pii: E44. doi: 10.3390/toxins9020044. Review.


Grey matter abnormalities in methcathinone abusers with a Parkinsonian syndrome.

Juurmaa J, Menke RA, Vila P, Müürsepp A, Tomberg T, Ilves P, Nigul M, Johansen-Berg H, Donaghy M, Stagg CJ, Stepens A, Taba P.

Brain Behav. 2016 Aug 18;6(11):e00539. eCollection 2016 Nov.


"Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies".

Peres TV, Schettinger MR, Chen P, Carvalho F, Avila DS, Bowman AB, Aschner M.

BMC Pharmacol Toxicol. 2016 Nov 4;17(1):57. Review.


Disease-Toxicant Interactions in Parkinson's Disease Neuropathology.

Kwakye GF, McMinimy RA, Aschner M.

Neurochem Res. 2017 Jun;42(6):1772-1786. doi: 10.1007/s11064-016-2052-4. Epub 2016 Sep 9.


Structural Elements in the Transmembrane and Cytoplasmic Domains of the Metal Transporter SLC30A10 Are Required for Its Manganese Efflux Activity.

Zogzas CE, Aschner M, Mukhopadhyay S.

J Biol Chem. 2016 Jul 29;291(31):15940-57. doi: 10.1074/jbc.M116.726935. Epub 2016 Jun 15.


Direct Comparison of Manganese Detoxification/Efflux Proteins and Molecular Characterization of ZnT10 Protein as a Manganese Transporter.

Nishito Y, Tsuji N, Fujishiro H, Takeda TA, Yamazaki T, Teranishi F, Okazaki F, Matsunaga A, Tuschl K, Rao R, Kono S, Miyajima H, Narita H, Himeno S, Kambe T.

J Biol Chem. 2016 Jul 8;291(28):14773-87. doi: 10.1074/jbc.M116.728014. Epub 2016 May 10.


p73 gene in dopaminergic neurons is highly susceptible to manganese neurotoxicity.

Kim DS, Jin H, Anantharam V, Gordon R, Kanthasamy A, Kanthasamy AG.

Neurotoxicology. 2017 Mar;59:231-239. doi: 10.1016/j.neuro.2016.04.012. Epub 2016 Apr 20.


Transcriptional Regulation of Human Transforming Growth Factor-α in Astrocytes.

Karki P, Johnson J Jr, Son DS, Aschner M, Lee E.

Mol Neurobiol. 2017 Mar;54(2):964-976. doi: 10.1007/s12035-016-9705-9. Epub 2016 Jan 21.


Changes in Brain Metallome/Metabolome Pattern due to a Single i.v. Injection of Manganese in Rats.

Neth K, Lucio M, Walker A, Zorn J, Schmitt-Kopplin P, Michalke B.

PLoS One. 2015 Sep 18;10(9):e0138270. doi: 10.1371/journal.pone.0138270. eCollection 2015.


Urgent need to reevaluate the latest World Health Organization guidelines for toxic inorganic substances in drinking water.

Frisbie SH, Mitchell EJ, Sarkar B.

Environ Health. 2015 Aug 13;14:63. doi: 10.1186/s12940-015-0050-7. Review.


Manganese-Induced Parkinsonism and Parkinson's Disease: Shared and Distinguishable Features.

Kwakye GF, Paoliello MM, Mukhopadhyay S, Bowman AB, Aschner M.

Int J Environ Res Public Health. 2015 Jul 6;12(7):7519-40. doi: 10.3390/ijerph120707519. Review.


Loss of pdr-1/parkin influences Mn homeostasis through altered ferroportin expression in C. elegans.

Chakraborty S, Chen P, Bornhorst J, Schwerdtle T, Schumacher F, Kleuser B, Bowman AB, Aschner M.

Metallomics. 2015 May;7(5):847-56. doi: 10.1039/c5mt00052a. Epub 2015 Mar 13.


Microfluidic platform integrated with worm-counting setup for assessing manganese toxicity.

Zhang B, Li Y, He Q, Qin J, Yu Y, Li X, Zhang L, Yao M, Liu J, Chen Z.

Biomicrofluidics. 2014 Sep 24;8(5):054110. doi: 10.1063/1.4896663. eCollection 2014 Sep.


Age- and manganese-dependent modulation of dopaminergic phenotypes in a C. elegans DJ-1 genetic model of Parkinson's disease.

Chen P, DeWitt MR, Bornhorst J, Soares FA, Mukhopadhyay S, Bowman AB, Aschner M.

Metallomics. 2015 Feb;7(2):289-98. doi: 10.1039/c4mt00292j.


α-Synuclein protects against manganese neurotoxic insult during the early stages of exposure in a dopaminergic cell model of Parkinson's disease.

Harischandra DS, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG.

Toxicol Sci. 2015 Feb;143(2):454-68. doi: 10.1093/toxsci/kfu247. Epub 2014 Nov 21.


SLC30A10 is a cell surface-localized manganese efflux transporter, and parkinsonism-causing mutations block its intracellular trafficking and efflux activity.

Leyva-Illades D, Chen P, Zogzas CE, Hutchens S, Mercado JM, Swaim CD, Morrisett RA, Bowman AB, Aschner M, Mukhopadhyay S.

J Neurosci. 2014 Oct 15;34(42):14079-95. doi: 10.1523/JNEUROSCI.2329-14.2014.

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