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Items: 1 to 20 of 132

1.

Serum-free Erythroid Differentiation for Efficient Genetic Modification and High-Level Adult Hemoglobin Production.

Uchida N, Demirci S, Haro-Mora JJ, Fujita A, Raines LN, Hsieh MM, Tisdale JF.

Mol Ther Methods Clin Dev. 2018 Mar 22;9:247-256. doi: 10.1016/j.omtm.2018.03.007. eCollection 2018 Jun 15.

2.

Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch.

Liu N, Hargreaves VV, Zhu Q, Kurland JV, Hong J, Kim W, Sher F, Macias-Trevino C, Rogers JM, Kurita R, Nakamura Y, Yuan GC, Bauer DE, Xu J, Bulyk ML, Orkin SH.

Cell. 2018 Apr 5;173(2):430-442.e17. doi: 10.1016/j.cell.2018.03.016. Epub 2018 Mar 29.

PMID:
29606353
3.

SOX6 Downregulation Induces γ-Globin in Human β-Thalassemia Major Erythroid Cells.

Li J, Lai Y, Luo J, Luo L, Liu R, Liu Z, Zhao W.

Biomed Res Int. 2017;2017:9496058. doi: 10.1155/2017/9496058. Epub 2017 Nov 28.

4.

Corrected and Republished from: BCL11A Is a Critical Component of a Transcriptional Network That Activates RAG Expression and V(D)J Recombination.

Lee BS, Lee BK, Iyer VR, Sleckman BP, Shaffer AL 3rd, Ippolito GC, Tucker HO, Dekker JD.

Mol Cell Biol. 2017 Dec 13;38(1). pii: e00362-17. doi: 10.1128/MCB.00362-17. Print 2018 Jan 1.

5.

SINCERITIES: Inferring gene regulatory networks from time-stamped single cell transcriptional expression profiles.

Papili Gao N, Ud-Dean SMM, Gandrillon O, Gunawan R.

Bioinformatics. 2017 Sep 14. doi: 10.1093/bioinformatics/btx575. [Epub ahead of print]

6.

Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes.

Kojo S, Tanaka H, Endo TA, Muroi S, Liu Y, Seo W, Tenno M, Kakugawa K, Naoe Y, Nair K, Moro K, Katsuragi Y, Kanai A, Inaba T, Egawa T, Venkatesh B, Minoda A, Kominami R, Taniuchi I.

Nat Commun. 2017 Sep 26;8(1):702. doi: 10.1038/s41467-017-00768-1.

7.

In Vitro Hb Production in B-thalassemia Patients Is Not a Predictor of Clinical Responsiveness to Hydroxyurea.

Mahdavi MR, Pourfarzad F, Kosaryan M, Akbari MT.

Iran J Public Health. 2017 Jul;46(7):948-956.

8.

Haematopoietic stem and progenitor cells from human pluripotent stem cells.

Sugimura R, Jha DK, Han A, Soria-Valles C, da Rocha EL, Lu YF, Goettel JA, Serrao E, Rowe RG, Malleshaiah M, Wong I, Sousa P, Zhu TN, Ditadi A, Keller G, Engelman AN, Snapper SB, Doulatov S, Daley GQ.

Nature. 2017 May 25;545(7655):432-438. doi: 10.1038/nature22370. Epub 2017 May 17.

9.

Epo reprograms the epigenome of erythroid cells.

Perreault AA, Benton ML, Koury MJ, Brandt SJ, Venters BJ.

Exp Hematol. 2017 Jul;51:47-62. doi: 10.1016/j.exphem.2017.03.004. Epub 2017 Apr 12.

PMID:
28410882
10.

Long-Term Engraftment and Fetal Globin Induction upon BCL11A Gene Editing in Bone-Marrow-Derived CD34+ Hematopoietic Stem and Progenitor Cells.

Chang KH, Smith SE, Sullivan T, Chen K, Zhou Q, West JA, Liu M, Liu Y, Vieira BF, Sun C, Hong VP, Zhang M, Yang X, Reik A, Urnov FD, Rebar EJ, Holmes MC, Danos O, Jiang H, Tan S.

Mol Ther Methods Clin Dev. 2017 Jan 11;4:137-148. doi: 10.1016/j.omtm.2016.12.009. eCollection 2017 Mar 17.

11.

Reciprocal regulation of γ-globin expression by exo-miRNAs: Relevance to γ-globin silencing in β-thalassemia major.

Sun KT, Huang YN, Palanisamy K, Chang SS, Wang IK, Wu KH, Chen P, Peng CT, Li CY.

Sci Rep. 2017 Mar 16;7(1):202. doi: 10.1038/s41598-017-00150-7.

12.

Reactivating Fetal Hemoglobin Expression in Human Adult Erythroblasts Through BCL11A Knockdown Using Targeted Endonucleases.

Bjurström CF, Mojadidi M, Phillips J, Kuo C, Lai S, Lill GR, Cooper A, Kaufman M, Urbinati F, Wang X, Hollis RP, Kohn DB.

Mol Ther Nucleic Acids. 2016;5:e351. doi: 10.1038/mtna.2016.52.

13.

Animal models of β-hemoglobinopathies: utility and limitations.

McColl B, Vadolas J.

J Blood Med. 2016 Nov 4;7:263-274. eCollection 2016. Review.

14.

Emerging cellular and gene therapies for congenital anemias.

Ludwig LS, Khajuria RK, Sankaran VG.

Am J Med Genet C Semin Med Genet. 2016 Dec;172(4):332-348. doi: 10.1002/ajmg.c.31529. Epub 2016 Oct 28. Review.

15.

Distinct gene expression program dynamics during erythropoiesis from human induced pluripotent stem cells compared with adult and cord blood progenitors.

Merryweather-Clarke AT, Tipping AJ, Lamikanra AA, Fa R, Abu-Jamous B, Tsang HP, Carpenter L, Robson KJ, Nandi AK, Roberts DJ.

BMC Genomics. 2016 Oct 21;17(1):817.

16.

Strict in vivo specificity of the Bcl11a erythroid enhancer.

Smith EC, Luc S, Croney DM, Woodworth MB, Greig LC, Fujiwara Y, Nguyen M, Sher F, Macklis JD, Bauer DE, Orkin SH.

Blood. 2016 Nov 10;128(19):2338-2342. doi: 10.1182/blood-2016-08-736249. Epub 2016 Oct 5.

17.

Bcl11a Deficiency Leads to Hematopoietic Stem Cell Defects with an Aging-like Phenotype.

Luc S, Huang J, McEldoon JL, Somuncular E, Li D, Rhodes C, Mamoor S, Hou S, Xu J, Orkin SH.

Cell Rep. 2016 Sep 20;16(12):3181-3194. doi: 10.1016/j.celrep.2016.08.064.

18.

Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype.

Brendel C, Guda S, Renella R, Bauer DE, Canver MC, Kim YJ, Heeney MM, Klatt D, Fogel J, Milsom MD, Orkin SH, Gregory RI, Williams DA.

J Clin Invest. 2016 Oct 3;126(10):3868-3878. doi: 10.1172/JCI87885. Epub 2016 Sep 6.

19.

Featured Article: Modulation of fetal hemoglobin in hereditary persistence of fetal hemoglobin deletion type-2, compared to Sicilian δβ-thalassemia, by BCL11A and SOX6-targeting microRNAs.

Fornari TA, Lanaro C, Albuquerque DM, Ferreira R, Costa FF.

Exp Biol Med (Maywood). 2017 Feb;242(3):267-274. doi: 10.1177/1535370216668052. Epub 2016 Oct 4.

20.

Normal hematologic parameters and fetal hemoglobin silencing with heterozygous IKZF1 mutations.

Abdulhay N, Fiorini C, Kumánovics A, Sun AA, Hansen-Rejali J, Voelkerding KV, Rosenzweig SD, Hill HR, Sankaran VG.

Blood. 2016 Oct 20;128(16):2100-2103. doi: 10.1182/blood-2016-08-731943. Epub 2016 Aug 31. No abstract available.

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