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Synergistic interactions with PI3K inhibition that induce apoptosis.

Zwang Y, Jonas O, Chen C, Rinne ML, Doench JG, Piccioni F, Tan L, Huang HT, Wang J, Ham YJ, O'Connell J, Bhola P, Doshi M, Whitman M, Cima M, Letai A, Root DE, Langer RS, Gray N, Hahn WC.

Elife. 2017 May 31;6. pii: e24523. doi: 10.7554/eLife.24523.


B1, a novel HDAC inhibitor, induces apoptosis through the regulation of STAT3 and NF-κB.

Cheng MH, Wong YH, Chang CM, Yang CC, Chen SH, Yuan CL, Kuo HM, Yang CY, Chiu HF.

Int J Mol Med. 2017 May;39(5):1137-1148. doi: 10.3892/ijmm.2017.2946. Epub 2017 Apr 7.


Rational Redesign of a Functional Protein Kinase-Substrate Interaction.

Chen C, Nimlamool W, Miller CJ, Lou HJ, Turk BE.

ACS Chem Biol. 2017 May 19;12(5):1194-1198. doi: 10.1021/acschembio.7b00089. Epub 2017 Mar 29.


Biochemical and biophysical investigations of the interaction between human glucokinase and pro-apoptotic BAD.

Rexford A, Zorio DA, Miller BG.

PLoS One. 2017 Feb 9;12(2):e0171587. doi: 10.1371/journal.pone.0171587. eCollection 2017.


HK2 Recruitment to Phospho-BAD Prevents Its Degradation, Promoting Warburg Glycolysis by Theileria-Transformed Leukocytes.

Haidar M, Lombès A, Bouillaud F, Kennedy EJ, Langsley G.

ACS Infect Dis. 2017 Mar 10;3(3):216-224. doi: 10.1021/acsinfecdis.6b00180. Epub 2017 Jan 24.


Upregulation of Akt/NF-κB-regulated inflammation and Akt/Bad-related apoptosis signaling pathway involved in hepatic carcinoma process: suppression by carnosic acid nanoparticle.

Tang B, Tang F, Wang Z, Qi G, Liang X, Li B, Yuan S, Liu J, Yu S, He S.

Int J Nanomedicine. 2016 Nov 30;11:6401-6420. eCollection 2016.


SMAD4 loss enables EGF, TGFβ1 and S100A8/A9 induced activation of critical pathways to invasion in human pancreatic adenocarcinoma cells.

Moz S, Basso D, Bozzato D, Galozzi P, Navaglia F, Negm OH, Arrigoni G, Zambon CF, Padoan A, Tighe P, Todd I, Franchin C, Pedrazzoli S, Punzi L, Plebani M.

Oncotarget. 2016 Oct 25;7(43):69927-69944. doi: 10.18632/oncotarget.12068.


Specific inhibition of p110α subunit of PI3K: putative therapeutic strategy for KRAS mutant colorectal cancers.

Fernandes MS, Melo S, Velho S, Carneiro P, Carneiro F, Seruca R.

Oncotarget. 2016 Oct 18;7(42):68546-68558. doi: 10.18632/oncotarget.11843.


Class I HDAC inhibitor mocetinostat induces apoptosis by activation of miR-31 expression and suppression of E2F6.

Zhang Q, Sun M, Zhou S, Guo B.

Cell Death Discov. 2016 Jun 6;2:16036. doi: 10.1038/cddiscovery.2016.36. eCollection 2016.


Jnk1 Deficiency in Hematopoietic Cells Suppresses Macrophage Apoptosis and Increases Atherosclerosis in Low-Density Lipoprotein Receptor Null Mice.

Babaev VR, Yeung M, Erbay E, Ding L, Zhang Y, May JM, Fazio S, Hotamisligil GS, Linton MF.

Arterioscler Thromb Vasc Biol. 2016 Jun;36(6):1122-31. doi: 10.1161/ATVBAHA.116.307580. Epub 2016 Apr 21.


Autophagy postpones apoptotic cell death in PRRSV infection through Bad-Beclin1 interaction.

Zhou A, Li S, Khan FA, Zhang S.

Virulence. 2016;7(2):98-109. doi: 10.1080/21505594.2015.1131381. Epub 2015 Dec 15.


Repression of AKT signaling by ARQ 092 in cells and tissues from patients with Proteus syndrome.

Lindhurst MJ, Yourick MR, Yu Y, Savage RE, Ferrari D, Biesecker LG.

Sci Rep. 2015 Dec 11;5:17162. doi: 10.1038/srep17162.


BACE1 activity impairs neuronal glucose oxidation: rescue by beta-hydroxybutyrate and lipoic acid.

Findlay JA, Hamilton DL, Ashford ML.

Front Cell Neurosci. 2015 Oct 1;9:382. doi: 10.3389/fncel.2015.00382. eCollection 2015.


The BH3-only protein BIM contributes to late-stage involution in the mouse mammary gland.

Schuler F, Baumgartner F, Klepsch V, Chamson M, Müller-Holzner E, Watson CJ, Oh S, Hennighausen L, Tymoszuk P, Doppler W, Villunger A.

Cell Death Differ. 2016 Jan;23(1):41-51. doi: 10.1038/cdd.2015.61. Epub 2015 Jun 5.


Tat-antioxidant 1 protects against stress-induced hippocampal HT-22 cells death and attenuate ischaemic insult in animal model.

Kim SM, Hwang IK, Yoo DY, Eum WS, Kim DW, Shin MJ, Ahn EH, Jo HS, Ryu EJ, Yong JI, Cho SW, Kwon OS, Lee KW, Cho YS, Han KH, Park J, Choi SY.

J Cell Mol Med. 2015 Jun;19(6):1333-45. doi: 10.1111/jcmm.12513. Epub 2015 Mar 17.


Histone deacetylase 6 (HDAC6) promotes the pro-survival activity of 14-3-3ζ via deacetylation of lysines within the 14-3-3ζ binding pocket.

Mortenson JB, Heppler LN, Banks CJ, Weerasekara VK, Whited MD, Piccolo SR, Johnson WE, Thompson JW, Andersen JL.

J Biol Chem. 2015 May 15;290(20):12487-96. doi: 10.1074/jbc.M114.607580. Epub 2015 Mar 13.


Regulation of mitochondrial nutrient and energy metabolism by BCL-2 family proteins.

Giménez-Cassina A, Danial NN.

Trends Endocrinol Metab. 2015 Apr;26(4):165-75. doi: 10.1016/j.tem.2015.02.004. Epub 2015 Mar 5. Review.


Phospho-BAD BH3 mimicry protects β cells and restores functional β cell mass in diabetes.

Ljubicic S, Polak K, Fu A, Wiwczar J, Szlyk B, Chang Y, Alvarez-Perez JC, Bird GH, Walensky LD, Garcia-Ocaña A, Danial NN.

Cell Rep. 2015 Feb 3;10(4):497-504. doi: 10.1016/j.celrep.2014.12.056. Epub 2015 Jan 29.


The BH3-only protein Bad is dispensable for TNF-mediated cell death.

Ottina E, Sochalska M, Sgonc R, Villunger A.

Cell Death Dis. 2015 Jan 22;6:e1611. doi: 10.1038/cddis.2014.575.


Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia.

Chan SM, Thomas D, Corces-Zimmerman MR, Xavy S, Rastogi S, Hong WJ, Zhao F, Medeiros BC, Tyvoll DA, Majeti R.

Nat Med. 2015 Feb;21(2):178-84. doi: 10.1038/nm.3788. Epub 2015 Jan 19.

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